Varsha Manucha, MD

The only 👩 in the these pictures is my MOM 🤩 Year - 1965 The saree clad petite 👩 stands tall amongst all the men Strong, resilient, full of love & compassion ❤️ Everyday is Mother’s Day! #prouddaughter #womeninspiringwomen #MyMomMyHero @strongwomenever

Happy Lab week to all the amazing lab professionals who make magic make timely, accurate diagnosis and patient care possible every day. @UMMC_Pathology #labweek

🎯A case of nasal Rhinosporidiosis in a child. 🧐Sporangium of variable sizes w sporangiospores. #entpath #pathology

Bright and early @UMMC_Pathology team @UMMC_Cancer @SeeTestTreatSTT

Cervical PAP test saves lives—this case is a reminder why. HSIL in a patient with a negative high-risk HPV performed without cytology, highlighting an important truth: Screening isn’t one-size-fits-all, and PAP still plays a critical role in catching what other tests can miss

We are super excited and looking forward to hosting the STT event tomorrow @UMMC_Cancer

Grateful to share about See, Test & Treat (STT) on @WLBT earlier and again today on @WJTV. Join us on April 11 at @UMMC_Cancer for free cancer screenings with @UMMC_Pathology team. Early detection saves lives. #SeeTestTreat #CancerScreening #HealthEquity

@slusagar I can so relate to this ☹️

folks working back home not in San Antonio👀l #pathtwitter posts from #USCAP2026

Here's a fun one - FNA, guess the organ.

@sam_albadri @MayoClinicPath Wow!

@VarshaManuchaMD @MayoClinicPath The other case had a history of pancreatic adenocarcioma

🧵 Case highlight: Female patient with acute kidney injury and history of breast cancer, treated with chemotherapy. Renal biopsy (PAS) shows atypical hyperchromatic cells occluding glomerular intracapillary lumina. PAS highlights segmental double contouring of capillary loops, suggesting endothelial injury. Immunohistochemistry confirms the origin:
🔹 Tumor cells positive for TRPS-1 and GATA3 → consistent with metastatic breast carcinoma
🔹 Enlarged endothelial cells highlighted by ERG immunostain Diagnosis: Glomerular metastatic carcinoma with intracapillary tumor emboli and secondary endothelial injury. In patients with prior malignancy and chemotherapy exposure, unexplained AKI should prompt consideration of intraglomerular tumor involvement. @Renalpathsoc @MayoClinicNeph @MayoClinicPath

Value of urine cytology!!

@sam_albadri @MayoClinicPath The other case also had a known history? Breast?

@VarshaManuchaMD That is my second case here @MayoClinicPath

“Histiocytes - cells that are master of looking important” - can often be a culprit causing diagnostic confusion in cytopathology. They are often “loud background noise and diagnostically empty.”

@LaraHarikMD @rovingatuscap @h_alahmadie @slusagar @priyaraomd @MiPathKunju @lalpritu @Williamson_SR @MichelleDunno17 What a generous biopsy! Thanks for sharing the case.

Can you make the diagnosis of TFE3 rearranged rcc on needle biopsy? Yes!: 1) if you think about it and 2) are lucky to have enough tissue! (confirmed NONO:TFE3) TFE3 IHC is not perfect but can be helpful as part of a screening panel #GUPATH #pathology #pathres #kidneycancer

Prostate Biopsy lightning round 2/2 65 year old with elevated PSA Test your H&E skills; IHC & my Dx 👇 #prostate #GUPATh #pathology #pathres

@MauroSaieg @mdlozanoe @sza_jhcyto @tlabiano @edusqo @Sara_Jiang @MauroSaieg Very nice! Truly - the best way to make a change is by leading it! On a lighter side - ChatGPT is a male?

Are we there yet ? How generative AI may shape the future of cytopathology. @CanceCytopath @mdlozanoe @sza_jhcyto @tlabiano @edusqo @Sara_Jiang @VarshaManuchaMD

Prostate Biopsy lightning round 1/2 55 year old with elevated PSA Test your H&E skills; IHC & my Dx 👇 #prostate #GUPATh #pathology #pathres