Vincent Nicholson

I’m excited to share my most recent manuscript describing an approach to assess local conformational sampling in simulations of intrinsically disordered proteins. This one’s for my computational biophysics aficionados biorxiv.org/content/10.110… - a 🧵

It took me 10 years to master all 24 of these statistics concepts. In the next 24 days, I'll teach them to you one by one (with examples of how I've used them in business cases). Here's what's coming: 1. Probability Distribution 2. Regression 3. Hypothesis Testing 4. Central Tendency 5. Bayesian Statistics 6. Descriptive Statistics 7. Distribution 8. Sampling 9. Confidence Interval 10. Correlation 11. Covariance 12. Dimensionality Reduction 13. Central Limit Theorem 14. Normal Distribution 15. Population and Sample 16. Skewness 17. Variance 18. Data Types 19. Probability 20. Conditional Probability 21. P Values and Level of Significance 22. Variability 23. Over and Under-Sampling 24. Estimation There you have it- my top 24 stats concepts all data scientists need to know. The next problem you'll face is how to apply data science to business. I'd like to help. I’ve spent 100 hours consolidating my learnings into a free 5-day course, How to Solve Business Problems with Data Science. It comes with: 300+ lines of R and Python code 5 bonus trainings 2 systematic frameworks 1 complete roadmap to avoid mistakes and start solving business problems with data science, TODAY. 👉 Here it is for free: learn.business-science.io/free-solve-bus…

The new PhD candidate, the post-doc, and the PI

I'm excited to announce that our lab is moving to @SyracuseU!! We will continue our exploration of how (disordered) proteins sense and respond to changes in their environment, and 📢HIRING AT ALL LEVELS. Get in touch if you're interested! Some details on this move below: 1/5

Our paper on the mechanisms of protein thermal stabilization by osmolytes is out @nchembio. We found that osmolytes thermally stabilize many proteins in situ using various mechanisms (but there's a dominant one – read the paper to find out). Read it here: nature.com/articles/s4158…

IDP GRS chairs @PelhamJackie & @JJAlston_ want to remind trainees to apply for the GRS! 🚨 Slots are filling quickly, so please submit your abstract ASAP to get a spot to share your disorderly science🍝! We hope to see you in Switzerland!

We’re excited to share our preprint where we show, for the first time, the atomically accurate design of VHH antibodies!

Great question Ella! The LEAs we used in this study are incapable of forming hydrogels. We are unsure what structural transition promotes the protective function of LEAs. One possibility is that LEA proteins affect the properties of vitreous solids (ncbi.nlm.nih.gov/pmc/articles/P…)

Disordered proteins are ubiquitous and play myriad important roles in biology. The structural form of these proteins can change when the solution environment changes. But does this translate into function? We answer this question in our new preprint: tinyurl.com/3bwm2twf

Join the @boothbylab at the University of Wyoming! WALII PI Thomas Boothby is hiring a summer intern to help research how plants survive the solid state. Applications close 3/31. Learn more & Apply: bit.ly/WALII-jobs

@boothbylab members, John Ramirez and Vindya Kumara, and collaborators have a paper out analyzing the material properties of different sugars and how these properties relate to enzyme protection during desiccation. Read more here! tinyurl.com/3rp9twvt