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I’ll never understand why people live in cities when options exist
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Type VI Sophia System
1.6K posts
Type VI Sophia System
@wheezenfeld
mother of disease • former vibrio • microbiome truther • she/her • GT’21 🐝, @HMS_SysBio PhD any%
Katılım Ocak 2020
1K Takip Edilen516 Takipçiler
We will miss you immensely Arya!!!! So proud :')
Michael Baym@baym
Huge congratulations to Dr. Arya Kaul on his successful thesis defense today! The fourth from my lab
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@baym When my mom and I were moving my bed into my 2nd floor apartment we were struggling with it up the stairs and 2 unrelated neighbors helped move it upstairs to my bedroom in about 60 seconds. neither introduced themselves and i never encountered them again
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I don’t know where OP is based, but some of the kindest (but not nicest) people you’ll meet are surly Bostonians. If you need help they’ll go far out of their way for you. They just don’t waste your time with trivialities and expect the same respect from you
blue@bluewmist
this morning, while taking my golden retriever for a stroll, i walked past a middle-aged man wearing a sweatshirt that read in big bold print “never stop being kind to people.” i smiled and said “good morning” to him. he looked at me like i was an alien, said nothing, and kept walking. i’ve been thinking about this all day. i think it is the perfect metaphor for modern life.
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Type VI Sophia System retweetledi
Look out science twitter, @baym is starting his rotation in the lab and is already breaking things!
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Yay Arya Yay deletion borne fusion genes yay all the bacteria!!!
Kepler Mears@KeplerMears
🎉 New year, NEW PREPRINT! Bacteria exhibit astonishing genetic diversity, but where do new genes come from? My best friend Arya Kau (/labmate in the @baym lab) investigates how advantageous deletions can spawn new genes - "deletion-born fusions." 🧵:
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Service Alert: All services operating in the Providence (PVD) area will experience a delay due to a temporary hold on the tracks placed by local municipal officials. We will provide updates as more information becomes available. We sincerely apologize for the inconvenience.
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🍾 "The nested existence between MGEs is not an incidental result of selfish spread, but a driver of it." 🔥🔥🔥 bars! Super proud of Kepler for this work
(skull champagne flute also handcrafted by @KeplerMears )
Kepler Mears@KeplerMears
What is the best strategy to win any contest? Eliminate your opponents of course. Recently, my colleague @fernpizza showed how plasmids compete intracellularly (check out his paper just published in Science today!). Together with @baym, we now know how they can fight.
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Type VI Sophia System retweetledi
The project has excellent lore. From contamination to a integrated tool to classify mobility, A-Dog (Arya to civilians) has found AMR gene have been increasing on MGEs likely due to the use of antibiotics. Some great graphs in here!
Michael Baym@baym
What was antibiotic resistance like before we ever used antibiotics? How did we change what antibiotic resistance genes looked like over 100 years? Our paper looking at genomes from the NCTC historical collection now out in : microbiologyresearch.org/content/journa…
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This is one of the findings that really motivates my research: yes, antibiotic resistance genes are ancient, but the age of antibiotics has likely contributed to a big change in their mobility and of the landscape of MGEs we see today! Very happy for Arya & to see this published.
Michael Baym@baym
What was antibiotic resistance like before we ever used antibiotics? How did we change what antibiotic resistance genes looked like over 100 years? Our paper looking at genomes from the NCTC historical collection now out in : microbiologyresearch.org/content/journa…
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@Prokaryota @Kurz_Gesagt Oh awesome!!! Really exciting to see!
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Big news, friends! I've joined "Kurzgesagt – In a Nutshell" @Kurz_Gesagt as a Researcher & Fact-Checker 🐦💻🔍 Basically I get to nerd out over science with wildly creative people every day. Dream job! 💚 Go watch their stuff if you haven’t already!
@kurzgesagt" target="_blank" rel="nofollow noopener">youtube.com/@kurzgesagt
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Llama dolphin is bioweapon
Kepler Mears@KeplerMears
Llamas, dolphins and measles? Oh my! So thankful this story is finally breaking containment from my time in the @MangusoLab. Using pieces from viruses and llamas we engineered selective cell specific viral like particles with reduced immunogenicity for in vivo gene delivery
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Easter eggs from this paper over on bsky, come on over to see 🤲
Fernando Rossine@fernpizza
So happy that I can finally share the results of my first postdoc paper with @baym!! Turns out plasmids are an amazing system to study multi-scale evolution and we can track within-cell and between-cell dynamics! Here’s a photo of plasmids competing inside cells in a colony (1/n)
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Type VI Sophia System retweetledi
Thankful to have been given the opportunity to present my wacky little project at @crisprmeeting and grateful for the support from @baym @fernpizza and the rest of the lab!
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Type VI Sophia System retweetledi
Get ready to dance, our paper – Phage DisCo: targeted discovery of bacteriophages by co-culture – has been pre-printed! 🪩 This has been a really fun project to work on with @implosian, @baym, @nquinoneso, Kesther and Carmen! biorxiv.org/content/10.110… 1/
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Type VI Sophia System retweetledi
Excited to share a new preprint led by Indra Gonzalez Ojeda on a new tool to improve pangenome calling in bacteria, CLARC. biorxiv.org/content/10.110… . Passing output of Roary for S. pneumoniae populations through this tool reduces accessory genome > 30%, resolves other puzzles
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Type VI Sophia System retweetledi
Hey, it worked for me too. That is an interesting ripple on the pond of knowledge I hadn't anticipated (talking about @skryazhi's recent super cool paper)
Ethan Mollick@emollick
Being in the training data is useful. A few of the LLMs do a good “explain this like Ethan Mollick” - not nearly as good as me (in my opinion) - but kind of neat to see a form of intellectual legacy happen in real time.
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Type VI Sophia System retweetledi
My lab is up and running and just needs enthusiastic phage biologists to populate it! Contact me or apply in the link if you are interested in a postdoc exploring plasmid-dependent phage biology in beautiful (and super affordable!) upstate New York🍎healthresearch.wd1.myworkdayjobs.com/en-US/HRI_Care… 1/3
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Come see Amy at poster 174 & learn about how active prophages may change the trajectory & evolution of resistance to DNA damaging antibiotics 💊 ⚡️ #EMBOEvoEco
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Type VI Sophia System retweetledi
The bioRxiv version highlighted how anti-defense genes in plasmids are concentrated in the leading region under specialized ssDNA promoters (x.com/BursteinLab/st…).
In our new @Nature paper, we delve deeper and add experimental evidence. ✨Let's explore what's new! 2/7
Burstein lab@BursteinLab
Imagine you’re a plasmid conjugating into a recipient cell. How would you overcome CRISPR-Cas and other bacterial defense systems? Encoding anti-defense mechanisms is one obvious way. But where? And how? @BruriaSamuel set out to explore! 🧵 1/6 biorxiv.org/content/10.110…
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@BillHanage doi.org/10.1146/annure…
Not sure if you’re looking for a review or not but here’s a shameless plug 😌
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Anyone seen some interesting recent preprints on evolution of AMR that would be suitable for discussion in my class?
(or indeed interesting recent preprints in general from the intersection of evolution, epidemiology, and infectious disease 😀)
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