Will Matlock

🚨 New preprint! 🚨 We reveal that blaTEM-1 expression varies across the E. coli phylogeny, driving differences in co-amoxiclav resistance: biorxiv.org/content/10.110…

Today my first editorial article came out! It's both an intro to my Monash Bioethics Review special issue on antimicrobial stewardship and social justice, and also an original article examining issues with the precautionary principle as a justification. link.springer.com/article/10.100…

Finally out after peer review, our update on the integron model showing that translation rates of cassettes in first position influence the phenotypes conferred by others downstream. Great effort by @AndrePCarvalho nature.com/articles/s4146…

@jaegc @AndrePCarvalho Wahoo! Congrats!

@JaviF_86 I hope it was interesting ☺️

Spent the day thinking about this topic…first thing came to my feed here was this manuscript, more info added to my mental soup today 🤣🤯

@bbielggarcies11 Thank you!

Worth reading!

So exciting to see our (Liam Shaw, @Sheppard_Lab, @EpicFeil_) piece on the current state of plasmid epidemiology is now out: microbiologyresearch.org/content/journa… @NDMOxford @OxfordBiology @IneosOxford @MilnerCentre

Thanks for reading and let me know if you have any questions! (10/10)

2) How can we routinely incorporate phylogenetic information into AMR phenotype prediction? Hybrid assemblies are not always possible, so we need shortcuts. (9/10)

A thread on our study… (1/10)

@gushamilton Thanks! DM me if anything isn’t clear 😊

@wtmatlock Looks cool, need to read to understand the phylogeny bit! Don't really understand bacterial pop structure. Need to stick to humans which is easier!

🚨 New preprint! 🚨 We reveal that blaTEM-1 expression varies across the E. coli phylogeny, driving differences in co-amoxiclav resistance: biorxiv.org/content/10.110…

E. coli phylogeny drives co-amoxiclav resistance through variable expression of blaTEM-1 biorxiv.org/cgi/content/sh… #biorxiv_micrbio

Ever wondered how fast accessory genome dynamics of bacteria really is? In a new preprint we (@mrcmolari, Liam Shaw) explore how rapidly E coli picks up genes horizontally, breaks genome synteny, etc.. biorxiv.org/content/10.110… For a thread by Marco see @mrcmlr/112772499102225806" target="_blank" rel="nofollow noopener">mstdn.science/@mrcmlr/112772…