Georgios Mavropalias, PhD

Excellent and clear explanation of the benefits of being outdoors by #MedCram co-founder Prof Dr @RogerSeheult for people with #Arthrofibrosis. youtube.com/watch?v=jNkRqa…

I had an amazing time in Melbourne attending and presenting in the 2023 Annual Scientific Meeting of the Clinical Oncology Society of Australia the research I'm doing on exercise as medicine for cancer, and giving a presentation to the exercise oncology group in Deakin University on my current and future studies. Meet a lot of great people and Melbourne has amazing culture, bars, and Latin dance scene 😉

🎯 Unlocking the Power of Exercise for Non-Small Cell Lung Cancer Patients Undergoing Targeted Therapy 🎯 🔬 The Study in a Nutshell A recent focus has been put on patients diagnosed with non-small cell #LungCancer #cancer (NSCLC), particularly those who are undergoing targeted therapy. Researchers investigated the effects of an 8-week, high-intensity aerobic interval training program on various health outcomes. The metrics included peak oxygen consumption (VO2peak), muscle strength, #insulin resistance, and quality of life (QoL). The study discovered a significant improvement in exercise capacity and an alleviation of cancer-related symptoms like dyspnea (shortness of breath) and fatigue. 🏋️‍♀️ The Methodology 24 NSCLC patients were divided into a control group and an exercise group. The exercise group underwent individualized, high-intensity aerobic interval training for 8 weeks. Several outcome measures were assessed before and after the training, including VO2peak, muscle strength and endurance, and quality of life. ✅ Key Takeaways 1️⃣ Exercise is safe: No adverse events were reported during the 8-week training period. 2️⃣ VO2peak matters: An increase in VO2peak by 5.3% was observed. A higher VO2peak is positively correlated with long-term prognosis in NSCLC patients. 3️⃣ Alleviation of Symptoms: Participants reported less dyspnea and lower levels of #fatigue. 🚀 Why It's Important This is the first study to consider the combined effect of #exercise training and targeted therapy on NSCLC. While these patients had low exercise capacity, the study revealed that exercise could significantly improve this, along with enhancing circulatory, respiratory, and muscle functions. 👩‍⚕️👨‍⚕️ For Healthcare Professionals The study underscores the importance of incorporating exercise as a strategic component in the management and treatment of #NSCLC. Not only does exercise improve physiological parameters, but it also boosts the patient's quality of life. 💡 Conclusions While patients with NSCLC undergoing targeted therapy may have low exercise capacity, this study shows that #ExerciseIsMedicine. A focused and individualized exercise training regimen can make a difference in their treatment journey, offering improved health outcomes and better quality of life. pubmed.ncbi.nlm.nih.gov/22526147/

📚🔬 #ExerciseMedicine -> Regular exercise can improve natural killer (NK) cell infiltration in localized prostate cancer. NK cells, our immune system's vigilant defenders, play a crucial role in targeting and eliminating tumor cells. In the realm of cancer research, there's growing curiosity about how physical activity might influence these cells and potentially enhance their infiltration into #prostate tumors. This could be a key factor in understanding the protective effects of exercise on tumor development and progression. 🏃‍♂️💪🧬 The review delves into the theory that regular exercise, such as moderate or high-intensity interval training, might not only increase the number of NK cells but also 'prep' the #tumor environment for their infiltration, thereby potentially inhibiting tumor onset and progression. This could add another layer to the already recognized benefits of exercise in managing #cancer treatment side effects and improving survival rates. 🏋️‍♂️🚴‍♂️ However, the evidence is still evolving, and more extensive, controlled #clinicaltrials are needed to confirm these promising findings. The question of whether exercise can truly enhance the tumor-killing capacity of NK cells remains open, but the initial signs are encouraging. 🧐🔍 These findings could have significant implications in the management of patients with localized disease undergoing active surveillance or #radiation therapy, as well as in preventing #prostatecancer. The future of exercise and #ProstateCancerResearch is indeed exciting and could potentially reshape clinical practice and patient outcomes. As always, it's important to consult with a #healthcare professional before starting any new #exercise regimen, especially if you're dealing with cancer. Let's keep the conversation going and continue to move toward a healthier, more active future! 🌍💃🕺 #CancerResearch pubmed.ncbi.nlm.nih.gov/36546724/

@OpenRefine Great to see this! Is most of the java pure java or kotlin?

New Release for OpenRefine: 3.7.5 bit.ly/3PzyucE

💡 Men with advanced #prostate cancer and bone metastases can still perform and benefit from resistance exercise! 🏋️‍♂️💪Many have been hesitant to embrace exercise due to concerns of skeletal complications. However, an expertly designed and supervised resistance training program can actually enhance their physical function, activity level, and lean mass. 🌟 Twice-weekly resistance training sessions for 12 weeks at an exercise clinic led to improvements in muscle strength by ~11%, submaximal aerobic exercise capacity by ~5%, and ambulation by ~12%. The added benefit? A significant increase in lean mass by ~3%, playing a crucial role in protecting against muscle atrophy and potentially reducing the risk of falls, skeletal complications, and even mortality. The unique aspect of this approach? The selection of exercises is tailored to each individual, avoiding regions affected by bone #metastasis, to ensure their safety and efficacy. Participants are guided to perform the exercises with controlled, smooth movements, minimizing peak forces transmitted to the skeleton. 🎯 The intensity and volume of resistance exercises were progressive, starting with 12 to 8 repetition maximum (RM) and moving up to 2 - 4 sets per exercise. Every 2 weeks, both the number of RM and sets were gradually increased, with the load of each exercise adapted according to individual responses. This personalized approach ensures participants are continuously challenged while remaining safe. And they're not stopping there! In addition to these clinic sessions, participants were encouraged to supplement with home-based aerobic exercise sessions, such as walking or cycling, aiming to reach at least 150 minutes of moderate-intensity aerobic exercise each week. 🚴‍♂️🚶‍♂️ High attendance and compliance rates, along with the ability to maintain exercise intensity, all suggest that the exercise program was well-received and beneficial. It's a testament to the idea that with the right approach, exercise can indeed become medicine for everyone, regardless of their health status. This is an exciting step forward, as we work to redefine the boundaries of what's possible, even in challenging health circumstances. Here's to harnessing the power of movement, and reminding everyone that #ExerciseIsMedicine! #ProstateCancerResearch #CancerResearch #FightCancer #ProstateCancerAwareness pubmed.ncbi.nlm.nih.gov/23917308/

A study reveals how powerful movement is for men diagnosed with localized #prostate cancer. 👨‍⚕️🚶‍♂️💪 The data showcases the inverse relationship between brisk walking after diagnosis and the risk of prostate #cancer progression. In fact, men who walked briskly for 3+ hours a week experienced a 57% lower rate of cancer progression compared to those who walked less intensely and less frequently. This suggests that the pace of walking can play a significant role in managing prostate cancer. How does this happen? 🧐 #Exercise such as brisk walking may reduce insulin resistance, decrease bioavailable IGF-1, and increase adiponectin levels. These factors play a crucial role in affecting the proliferation and apoptosis of prostate cancer cells. While this study focused on walking, any form of regular, moderate physical activity could potentially have similar benefits. In fact, the study offers insights into the benefits of vigorous activity. 🏋️‍♂️🚴‍♂️ Although few men in this study engaged in such activities, the findings suggest an inverse association between vigorous activity and #prostatecancer progression. Men who performed vigorous activities for 3+ hours per week tended to have a lower risk, although more research is needed in this area to confirm these findings. The bottom line: stay active, stay healthy, and keep moving forward! - because #ExerciseIsMedicine 💚🏃‍♂️ pubmed.ncbi.nlm.nih.gov/21610110/ #ProstateCancerResearch #CancerResearch #FightCancer #ProstateCancerAwareness

"Fibrosis of skeletal muscle results from chronic inflammation, repeated injury, and hypoxia, which activate TGF-β and stimulate fibroblasts to transform into myofibroblasts." - 2022 Thanks to @x_centrik and @TonyBlazevich doi.org/10.1111/brv.12…

Did you know exercise is a potent "medicine" for managing #MultipleSclerosis symptoms? But wait, there's more - we can deliver these benefits digitally! 📲 However, there's a puzzle piece missing: how are our healthcare pros in Australia like physiotherapists (PTs), exercise physiologists (EPs), and occupational therapists (OTs) leveraging this tool? 🤷‍♂️ Recent research has unveiled some illuminating stats: - Familiarity with current exercise guidelines for MS varies: EPs lead the pack at 85.7%, followed by PTs (67.6%), and OTs (40%). - Confidence in prescribing digital exercises? EPs and PTs are soaring at 85% & 80%, but OTs? Just 35%. We need to bridge this gap! - The silver lining? A whopping interest in getting educated about telehealth exercises for MS is evident across all professions! Digging deeper, while occupational therapists are all in for focusing on behavior change, our EPs and PTs want to juggle both exercise AND behavior change. 💪 We aim to develop educational components to address the needs and preferences of each profession. Focus groups highlighted a driving force for embracing digital #ExerciseMedicine - making sure those living remotely or facing financial challenges can get the benefits of exercise without barriers. It's all about increasing accessibility and enhancing skills in delivering exercise for MS care. 🌏 However, like every rose has its thorns, there are hurdles too. Lack of time and finding the right fit with current practices have been identified. But the future looks bright, as these insights pave the way for training resources tailored to healthcare pros, ensuring top-notch exercise delivery in #MS care. Below is my presentation at the recent National Allied Health Conference; journal paper is coming soon! If you are interested in taking part in our free educational program for EPs, PTs, and OTs on how to deliver telehealth exercise and behavioural change in people with MS, please email us at MSHealthStudy@murdoch.edu.au

@E_C_S_S Subscribed!

Our latest weekly lesson discusses maximal fat oxidation. Watch it here: tinyurl.com/pnfm9c6t #WeAreSportScience

🎉 Get ready to rethink exercise! 🎉 @Channel7 news spotlighted the incredible research at @EdithCowanUni with the brilliant Ken Nosaka, @TonyBlazevich, and Ben Kirk, and we've got a game-changer for you. 📺 This isn't just about looking good in a swimsuit. It's about transforming lives. 💥 Let's get something straight: a solid gym workout is incredible and will never be replaced. Lifting weights, sweating it out, the sense of achievement - it's unmatched. 🏋️‍♂️💪 But let's face it, life gets busy. Sometimes, hitting the gym for several hours a week feels impossible. Ever heard of 'snack exercises'? 🍪💪 No, it's not munching cookies while doing squats (though that would be interesting!). These are short, punchy, 1-5 minute exercise regimes that are taking the world by storm! Professor Ken Nosaka in his study showed that doing ONE contraction per day (yes, only one) that focuses on loading the #eccentric portion of the movement (this is the phase when you lower the weight down) can increase strength by 12%... Only a single, 3-second contraction per day! 🤯 doi.org/10.1007/s00421… What's more? We're on a mission to make #exercise accessible to everyone, even those who prefer the couch to the treadmill. Our eccentric-biased home-based exercises are tailored for #sedentary folks. 🛋️🏋️🚀 The secret? These 5-minute daily routines can give you a higher-intensity workout with LOWER effort levels. It's like magic, but it's science! We're proving that exercise isn't just about sweat and tears; it's about SMART choices. Ben Kirk's PhD project at our university is delving into something extraordinary – eccentric-biased home-based exercises. Imagine achieving greater #health and #fitness with just 5-minute daily exercises! 🏃‍♂️💥 Who doesn't have 5 min in their day? We'll be publishing our findings soon, and we believe this will help shape the way we all look at fitness and well-being. So, whether it's going downstairs, carrying groceries, or even rocking out to your favorite song – remember, every movement counts. Let's make exercise a snack, not a chore! Remember, #ExerciseIsMedicine and #MovementIsLife !

🔬New Study: High Intensity Exercise 🏃‍♂️💨 Significantly Reduces Metastatic Cancer Risk 🎗️ In a landmark study (ref below), researchers at Tel Aviv University 🏛️ have discovered a powerful correlation between high-intensity aerobic exercise 🏋️‍♂️ and a dramatic reduction in the risk of developing metastatic #cancer, the type that spreads from where it originated to other parts of the body 🧬. The researchers identified that high-intensity #exercise increases glucose consumption by internal organs, leaving less energy available for #tumor growth 🌱. In essence, regular high-intensity exercise appears to "reprogram" our organs, increasing their nutrient demands and enabling them to outcompete cancer cells for resources 💪. Prof. Carmit Levy and Dr. Yftach Gepner combined data from a 20-year prospective study, looking at 2,734 men and women initially cancer-free. The results? Participants regularly engaging in high-intensity aerobic exercise had 72% less metastatic cancer than sedentary participants 🤯 🤯 🤯 In a separate study involving mice 🐁, the research team found that regular exercise reduced the development of metastatic tumors in the animals’ lymph nodes, lungs, and livers. The findings suggest that chronic physical activity could transform our organs into "superhero organs" 💥 with increased glucose uptake and mitochondrial activity, making them highly resistant to #cancer attacks. "When cancer attempts to attack these organs, it loses the fight," While more research is needed to understand the effects of different types of #exercisemedicine and the longevity of these protective effects, the implications of this study are significant 🌟. It's a strong reminder of the power of #exercise as an essential part of a healthy lifestyle and potentially, as a preventive strategy against metastatic cancer 🛡️. Remember, it's never too late to start incorporating regular exercise into your daily routine 🏊‍♀️🚴‍♂️🧘‍♀️. Let's keep moving for our #health 🍏! pubmed.ncbi.nlm.nih.gov/36084256/

Summer 🕶️, beach bar, iced ☕️ - and Gerontology research talk! Great meeting with @x_centrik for all of the above. 🙏🏻 Here’s to more of the same and future collaborations🙂

A single session of high-intensity interval exercise can significantly elevate serum myokine levels in patients with advanced #prostate cancer. Myokines are muscle-secreted cytokines that have been linked to #tumor suppression. The study, involving nine patients with metastatic castrate-resistant prostate cancer (mCRPC), found that serum levels of certain myokines (SPARC, OSM, IL-6, and IL-15) increased significantly immediately after exercise, and returned to baseline after 30 minutes of rest. 🧪🏋️‍♂️ Notably, this exercise-induced increase in #myokines was associated with a reduction in the growth of a prostate cancer cell line (DU-145), suggesting a potential therapeutic role for exercise in this patient group. 🚴‍♂️🔬 While further research is needed to optimize #exercisemedicine protocols and fully understand the underlying mechanisms, these preliminary findings underscore the immense potential of exercise as a complementary approach in #cancer management. The implications are profound, suggesting that regular intense exercise could play a pivotal role in managing advanced prostate cancer, and enhancing the effectiveness of other treatments. The study also underscores the importance of understanding the optimal exercise modes and intensities to maximize these benefits.🎯🏃‍♂️ Remember: Exercise and movement are medicine 🌟💖 So let’s keep moving, and continue exploring the extraordinary benefits of regular physical activity. doi.org/10.1038/s41391… #exerciseismedicine #movementislife

@DrTheoBampouras Great discussion! Looking forward to more in the future!

Taking the stairs can do more than just get you from one floor to another, it can significantly improve your health and fitness, especially if you're descending! 📉👵💪 A study explored the impact of Descending Stair Walking (DSW) on elderly obese women aged 60 years and above. This group was chosen as they are particularly at risk for health conditions that can be ameliorated by regular exercise, and this type of activity can be easily incorporated into their daily routines. In the study, one group was asked to walk downstairs (DSW group) while the other ascended (ASW group), both groups eliminating the opposing action using an elevator. To track the development of their fitness, participants completed this routine twice a week for 12 weeks, gradually increasing the number of repetitions. Outcomes were measured through blood samples for insulin sensitivity and lipid profile markers, as well as other physical health parameters like resting heart rate, blood pressure, and bone mineral density. Impressively, the DSW group experienced better health improvements than the ASW group! These included reductions in heart rate, systolic blood pressure, blood lipid levels, and increases in bone mineral density and muscle strength. Furthermore, their functional physical fitness also saw significant improvement. This study reinforces that sometimes, small changes in our daily routines can lead to substantial health benefits. So, next time you have the option, consider taking the stairs down instead of the elevator, and doing some #eccentricexercise ! 🏃‍♀️💪🏢 Now, if you don't live in a tall building, all you have to do is simply travel to Paris, take the elevator up the Eiffel Tower, and go down the stairs like I did a few days ago. Easy! pubmed.ncbi.nlm.nih.gov/28291022/ #ExerciseIsMedicine #MovementIsMedicine 🏋️‍♀️🚶‍♀️🏃‍♀️💓

If I could bottle up Paris and give it to everyone as a health supplement, I'd be out of business! 🇫🇷🍾 You see, as an exercise scientist, I have a knack for observing the ways people move in their daily lives, and Parisians offered a fascinating spectacle! Just got back from a 10-day trip to the #ECSS conference and my, Parisians have it figured out. Their diet is a culinary dream come true: Bread 🥖, pastries 🥐, sugar, butter 🧈... the works! But take a stroll down Champs-Élysées and you won't see an obesity crisis. Yes, despite the myth that French cuisine means pastries, sugar, and butter galore, the Parisians are in fantastic shape! Why? Paris, my friends, is a lesson in #ExerciseMedicine! 🏃‍♀️💪 The secret? It's not just about the food, it's the lifestyle! 🚶‍♀️🚶‍♂️Walking. French locals, not just the tourists, are constantly on the move. Paris, with its romantic architecture, historic streets, and inviting parks, is a city built for walking. Pedestrian-friendly, great public transit, and an abundance of enticing shops that are far more appealing than any indoor mall, make walking a delightful necessity. It's a city built to be experienced on foot. Each turn, a spectacle for the eyes. Each patisserie, a sensory delight. And oh, the metros and buses! A marvel of punctuality and convenience, they take you to every corner of the city but leave you enough walking to do. If this isn't #MovementMedicine, I don't know what is! But here's the pièce de résistance: the Parcours Sportif! 🌳🏞️ This isn't your ordinary park. It's a forest converted into an outdoor fitness haven. Trails peppered with pull-up bars and other exercise challenges, an #ExerciseScientist's dream. Took some snaps to show you what I mean 📸 (Swipe left!) What if we turned our cities into places where walking wasn't just possible, but delightful? What if we took cues from Paris and turned everyday movement into an exciting part of our day? 🤔 I say let's make our cities more walkable. Let's make our parks more like Parcours Sportif. Let's bring exercise back into our daily lives and make #ExerciseisMedicine and #MovementisMedicine a reality! 🌍🏞️💪 #ParisLessons #WalkableCities #FitnessGoals #MakeMovementGreatAgain

#DidYouKnow Berries are a great way to decrease inflammation within the body and are easy to incorporate into your diet. You can eat them plain, blend them in a nourishing smoothie, or top them over oatmeal or yogurt. bit.ly/3NlOM6g #ResearchMatters

@MGalvosas Bangle js 2. Open source, hackable, built to last, respects the user

Which smartwatch do you think is the best for tracking your daily activity?