Xin He

Come join us! UChicago Human Genetics has an open broad computational faculty search (with an emphasis on probabilistic machine learning). First round of application review will begin ~October 15th. apply.interfolio.com/149891 EOE/Vet/Disability.

Open TT faculty position at the department of medicine at the University of Chicago! Come join us in Genetic Medicine, Biomedical data science, Oncology, or any of the other sections. Apply here: academicjobs.uchicago.edu/positions/1318…

There is a position on my new team that just opened! We are looking for a creative and talented data scientist or statistical geneticist to help us use human genetics to drive value in drug development. careers.abbvie.com/en/job/lake-co…

Glad to see our paper, with @xinhe2 @mstephens999 @wescrouse Sheng and Kevin, is out today at @NatureGenet! nature.com/articles/s4158…. We developed a new statistical method, causal-TWAS or cTWAS, to reliably identify causal genes in genome-wide association studies (GWAS). 1/n

Introducing guided sparse factor analysis (GSFA), a statistical framework to detect changes in gene expression resulting from perturbations in single-cell CRISPR screening. @xinhe2 @MengjieChen6 OA paper: nature.com/articles/s4159…

@wu_xuebing Thanks, Xuebing!

Great department, great colleagues

The Department of Human Genetics at University of Chicago is searching for a faculty candidate in Computational genetic and genomics. Please share this job ad with your colleagues: apply.interfolio.com/127605

@lenghan_bioinfo @IndianaUniv @IUCancerCenter Congratulations!

I am thrilled to announce that I joined Indiana University School of Medicine as a David Brown Chair Professor in Genomic Medicine this June, with the support from Brown Center for Immunotherapy, Department of Biostatistics and Health Data Science, @IndianaUniv @IUCancerCenter

@mikelove @mstephens999 Agree! The comparison with GWAS makes good sense.

@xinhe2 @mstephens999 Maybe contemporary? there’s no reason to think it will be typical forever, like GWAS which started at lower sample sizes

I missed tweeting this when posted in Dec. Our attempt to ameliorate some problems with confounding in TWAS. Key idea is to compete (imputed) gene expression and SNPs against one another as explanations for an asssocation. biorxiv.org/content/10.110…

@mikelove @mstephens999 Good point. Thanks Michael! Maybe it's better to say something like, "most genes have one or few independent cis-eQTLs, in a typical eQTL study".

@mstephens999 Looks great. Adding to our journal club. I’m not sure this is universally true though “most genes have only one or few cis-eQTLs” Needs the phrase “detectable with n in small 100s”

@hakyim Somehow I missed your message - I only check twitter infrequently. But thanks for sharing! I wish I had seen it earlier.

@jeanv_morrison @mstephens999 @xinhe2 can you join?

@DevoEvoMed @ylenia_chiari @PhyloTox @NSF Cool project! Congratulation!

My department @UChicagoPHS now has a twitter account. If interested follow us and RT 👇

The work involved the collaborator @MengjieChen6, and many lab members, including @SimingZhao06.

We have a very successful collaboration with the lab of Jubao Duan, @jubao9812! We showed that variants disrupting chromatin accessibility in iPSC-derived neurons are highly enriched with risk variants of psychiatric disorders. See: science.sciencemag.org/content/369/65…

A statistical geneticist position at Merck: jobs.merck.com/us/en/job/R520…

@hyejung_won @mikelove @mstephens999 Thanks, Hyejung!

@xinhe2 @mikelove @mstephens999 Congrats Xin!

Very excited to share our paper, in collaboration with Chuan He's lab at U of Chicago and @mstephens999 : nature.com/articles/s4158…

Hello Everybody, I am now directing the Bioinformatics Core at U Chicago Biological Science Division. We are now recruiting a PhD level Bioinformatician (well compensated staff scientist). Please share the post. If you're on the market, please check us out.