Yumeng Zhan

The final version of our work on initiation-elongation transition by mammalian Pol II is now online! We visualized key transition steps during initiation and early elongation. Many thanks to Patrick @mpgpresident, Christian @c_dienemann, Elisa @EOberbeckmann and the Cramer lab!

Preprint Alert! Check out our take on the molecular basis for co-transcriptional H3K36me3 deposition by SETD2. biorxiv.org/content/10.110…

Excited to share our work showing how the Integrator complex terminates RNA polymerase II (Pol II) transcription i.e. removal of Pol II from the DNA template Published in @Nature nature.com/articles/s4158… Many thanks to my mentor Patrick Cramer @mpgpresident for unwavering support

Our work leads to a simple, three-step model of promoter escape by mammalian Pol II, which is regulated by RNA length, transcription bubble rewinding and elongation factors. Big thanks to Patrick @mpgpresident, Christian @c_dienemann, Elisa @EOberbeckmann and the Cramer lab!

Glad to share our new preprint on promoter escape by mammalian Pol II! We captured five transcription intermediates (de novo initiated from the PIC) and visualized the key steps where the initially transcribing complex (ITC) transitions into an elongation complex (EC).

In vitro system for the initiation-elongation transition captures early events in RNA polymerase II transcription: ⁦@ymzhan⁩, ⁦@c_dienemann⁩ et al., ⁦@EOberbeckmann⁩ et al. biorxiv.org/content/10.110…