Yurii

@DrBinChen @EnamineLtd Hello! @EnamineLtd is fine. Maybe it is a vacation period.

In the past few weeks, we sent a few inquiries to @EnamineLtd (a big compound supplier #ukraine) regarding the status of the compounds we requested to synthesize. No response! I hope they are doing well.

Some personal experience about life during war in Ukraine nature.com/articles/d4158…

Identification and Validation of New Interleukin-2 Ligands Using DNA-Encoded Libraries #drugdiscovery #openscience #DEL

The Medicinal Chemistry and Therapeutic Potential of LRH-1 Modulators cutt.ly/fT3j7n9 #drugdiscovery #openscience #medicinalchemistry

Discovery of Pyrazolo[3,4-d]pyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation cutt.ly/ET3hulm #drugdiscovery #openscience #inhibitors

Site-Specific Labeling of Endogenous Proteins Using CoLDR Chemistry cutt.ly/mTX8c08 #proteins #openscience #drugdiscovery

Flipping the Switch: Innovations in Inducible Probes for Protein Profiling cutt.ly/VTH1n5g #proteins #drugdiscovery #OpenScience

Modulation of Phosphoprotein Activity by Phosphorylation Targeting Chimeras (PhosTACs) - something interesting on the topic if targeted protein gegradation cutt.ly/xTEfl6B #drugdiscovery #OpenScience #proteindegradation

Discovery of Novel Small Molecule Inhibitors Disrupting the PCSK9-LDLR Interaction cutt.ly/BTEaS84 #drugdiscovery #inhibitors #OpenScience

Identification of covalent inhibitors that disrupt M. tuberculosis growth by targeting multiple serine hydrolases involved in lipid metabolism #openscience #drugdiscovery #covalentinhibitors

Really nice preprint by @LabSkiniotis - Structure Determination of Inactive-State GPCRs with a Universal Nanobody cutt.ly/LR8fEuF #GPCRs #drugdiscovery #openscience #CryoEM

Macrocyclic DNA-encoded chemical libraries: a historical perspective cutt.ly/pR38jzD #DEL #drugdiscovery #OpenScience #DNA

Microcrystal electron diffraction (MicroED) for the study of protein-ligand interactions and the potential for drug discovery cutt.ly/MR1lJvF #drugdiscovery #openscience #proteins

Not only in silico drug discovery: Molecular modeling towards in silico drug delivery formulations cutt.ly/MR1jEqx #drugdiscovery #openscience #computerscience

MS imaging of multicellular tumor spheroids and organoids as an emerging tool for personalized medicine and drug discovery cutt.ly/iRc71cA #drugdiscovery #OpenScience

Design of a mutant selective epidermal growth factor receptor inhibitor, that spans both orthosteric and allosteric sites by @DanaFarber and @uni_tue cutt.ly/pRc8Fim #drugdiscovery #OpenScience #inhibitor

Artificial intelligence and machine learning-aided drug discovery in central nervous system diseases: State-of-the-art and future directions cutt.ly/7Rc3JcV #AI #MachineLearning #OpenScience #drugdiscovery

Today came across an article, where scientists explore ethanol-triggered deactivation of lipid-enveloped viruses, like ebola, influenza, and #coronavirus. Based on the model virus Phi6. cutt.ly/eRffQ9T #openscience #viruses

Chemspace Catalog is already updated! Now you are able to search in more than 4.3 Billion molecules. cutt.ly/6ReAtB2 . #chemspace #organicchemistry #drugsynthesis #science #openscience #research #drugdiscovery #chemicals

An insight on effects of physicochemistry of the immunomodulatory drugs on lipophilicity, solubility, metabolism, permeability, intracellular bioavailability, and cell-based potency. cutt.ly/TE0nNqa #drugdiscovery #openscience #thalidomide