Mathieu Dedenon

How do density gradients impact active flows in polar fluids? We tackle this question by focusing on cell monolayers confined to a disc. We show that density gradients trigger a spiral-aster transition and coexistence of polar orientations. arxiv.org/abs/2307.15707 (1/8)

Days in a work week: 5 Days in a month: 30 Total new submissions to arXiv in September: 26,646 arXiv editorial and user support staff: 7 someone who is good at science please help me with this. our team isn't sleeping. #openaccess #preprints

New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tom_golde 🙌 @IBECBarcelona biorxiv.org/content/10.110…

Tiny molecular spirals in cells can scale up to control the twist and turn of entire tissues – an important step towards understanding left-right symmetry in tissues and organs. elifesciences.org/articles/10229…

If you’ve been following this account closely, you might already know methods to probe mechanics in vitro, but what about in live embryos? I’m Arthur Michaut , and I’m going to share a few great papers on this aspect of #EpithelialMechanics.

Dynamic shape remodeling of vesicles by internal active filaments biorxiv.org/content/10.110… #biorxiv_biophys

⚡ Our mini Higgs boson moment! In 2021, our 3D digital twin predicted left-right polarity oscillations in confined active fluids. 2025 -> experiments confirmed it. From theory to reality: simulation meets evidence. 📄 Theory: pubs.aip.org/aip/pof/articl… 📄 Experiment: journals.aps.org/prx/abstract/1…

🥁 New article 📢: My #research on #Mechanobiology of #development in @NatureComms. We studied the mechanical dynamics of embryonic cell populations during #Drosophila #gastrulation using #Brillouin microscopy: rdcu.be/ev6ZX @Prevedel_Lab @embl. Highlights in thread⬇️

Excited to share our new review with Emmanuel on tissue patterning in organ morphogenesis! We explore how repetitive patterns form, starting with the concept of L-systems and highlighting an ERK-mediated curvature feedback. Please check it out! sciencedirect.com/science/articl…

🚨 Second preprint of the week! We uncover the multiscale dynamics of active viscoelastic buckling in epithelia. We harness these mechanical instabilities for synthetic morphogenesis. Led by @onenimesa🙌. Theory by Marino Arroyo and team. biorxiv.org/content/10.110…

Have you ever thought about inflating tissues? Or maybe quickly deflating those inflated tissues? New #EpithelialMechanics pre-print: doi.org/10.1101/2025.0… 🧵with pressure control, multiscale buckling, patterned wrinkling

Thank you Xavi! Click on this to see epithelial pressure control, multiscale buckling, controlled wrinkling x.com/onenimesa/stat…

I worked on a group project that created a toy agent-based model simulating interactions between cells to form patterns. It was from a study on stripe formation in zebrafish, showing how simple cell interactions produce beautiful patterns in nature. nature.com/articles/ncomm…

How to turn a layer of fibroblasts into a tulip 🌷? Check out our new pre-print on shape-programmable living surfaces. Led by @pauguillamat @IBECBarcelona biorxiv.org/content/10.110…

Ever wondered how a tiny Hydra blob figures out where its head goes? Turns out, it's not just chemistry — it's feeling the stretch! Check out 👉 Mechanochemical patterning localizes the organizer of a luminal epithelium science.org/doi/10.1126/sc… #Hydra #morphogenesis #biophysics

Substrate properties and actin polymerization speed dictate universal modes of cell migration: gripping, slipping, and stick-slip biorxiv.org/content/10.110… #biorxiv_biophys

Researchers present a framework for the analysis of nematic materials and their defects, providing a full topological classification of the rewiring and crossing process that reveals the role of merons in mediating interactions between disclination lines. go.aps.org/3I8Lc0E

FINALLY out in @ScienceAdvances ! Proud to be first/co-corresponding author and part of a fantastic team! It's about Plexin signaling driving collective #cellmigration & organ sculpting - check out the videos science.org/doi/10.1126/sc… #CellBio #Science #DevBio #Microscopy

New paper! Fast matrix stress relaxation potentiates human monocyte 3D migration by generating protrusive forces and is dependent on the Cdc42-WASp axis. Thanks to our amazing collaborators! #viscoelasticity #mechanobiology @theChaudhurilab @Stanford_ChEMH pnas.org/doi/10.1073/pn…

Using a hydrodynamic model for the #actomyosin cortex of #cells in a confined 2D region, scientists show how active mechanochemical patterns can sense boundary curvature and resemble those seen in cells confined to micropatterned substrates. 🔗 go.aps.org/4kYhHwP

📣 New review! Dynamical systems and low-dimensional geometric structures in phase space help rationalize how embryos develop form and function, from large datasets. We focus on morphogenesis, cell differentiation, and their interconnection. @axplum #fig0010" target="_blank" rel="nofollow noopener">sciencedirect.com/science/articl…