Demon4932

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Demon4932

Demon4932

@Demon4932

SOL Entrou em Mart 2013
537 Seguindo176 Seguidores
Demon4932
Demon4932@Demon4932·
@bryan_johnson Delta Sleep-Inducing Peptide DSIP has been investigated as a peptide that may influence sleep architecture, including slow-wave sleep, and may also affect stress-related endocrine pathways such as the HPA axis, but its mechanism and clinical relevance in humans remain uncertain
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Bryan Johnson
Bryan Johnson@bryan_johnson·
Field report: night 2 on peptide CJC-1295 DAC. My sleep is wrecked. Two nights in and I feel like I crossed eight time zones. Minus the flight. What the sensors say: > Whoop: REM down about 40% from my 2-week baseline. Deep held. Disturbances up. > 8 Sleep: Flipped. Deep crashed to 36m. REM held. Taken together, a clear pattern of sleep disruption. The same truth just opposite shadows. Whoop reads REM from pulse and breathing at the wrist. Published validation flags REM as its weakest stage (21-min discrepancy vs PSG). Interruptions prevent the patterns from stabilizing, so REM gets lost first. 8 Sleep reads deep from body stillness against the mattress. Interruptions register as movement, so deep gets lost first. REM holds because the irregular breathing and small movements from interruptions look REM-like to the model. Neither sees brain waves. The real story is what an EEG would show. Interrupted, shallow sleep is how I feel, very reminiscent of jetlag. Why this might be happening: > Likely transient. Circadian rhythm, HPA axis, cortisol, all recalibrating to a new GH/IGF-1 setpoint. First two nights aren't a final verdict. > The only trial that measured it: CJC-1295 DAC preserved nocturnal GH pulses but raised basal GH 7.5-fold. Pulses on a raised floor. > GH pulses drive slow-wave sleep. A raised floor doesn't. > Elevated IGF-1 feeds back on hypothalamic GHRH. The nighttime GHRH surge that gates SWS may get blunted. > GH-IGF-1 axis also talks to the HPA clock. Tonic elevation can scramble cortisol rhythm. Jet lag, endogenously generated. Plan: Track a week. Compare 1 week post-CJC to 1 week of baseline. If still disrupted, abort or pivot to no-DAC + ipamorelin pre-bed.
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Bryan Johnson@bryan_johnson

Everyone's injecting peptides. Almost no one is measuring what they actually do. I'm stacking two peptides with opposite side effects and testing whether the downsides cancel while the benefits don't. Tirzepatide didn't work for me. I'm already top 1% on glucose control and body composition, so the marginal upside was small. And even at 20% of the starting dose (0.5 mg/week), my resting HR climbed 2–3 bpm. Even granting it might return to baseline in a couple weeks, not worth it. So I'm testing whether I can stack two peptides with opposite side effects and get the best of both worlds. Tirzepatide: metabolic optimization, yet raises my HR and can disrupt my sleep. CJC-1295 (a GHRH agonist that drives my own GH and IGF-1): growth and repair, but can blunt my glucose control and cause insulin resistance. Opposite vectors on autonomic tone. Opposite vectors on glucose. On paper, the side effects cancel but the benefits don't. That's my hypothesis. Now I'll measure it. Two CJC-1295 variants on the table: • DAC: weekly injection, extended half-life • No-DAC + Ipamorelin: daily, before bed The peptide community leans no-DAC, assuming it better preserves pulsatile GH release, with fewer side effects. However, the published data on DAC is better than the public consensus gives it credit for: sustained GHRH signaling without abolishing pulses, 7.5x overnight GH trough, >150% IGF-1 increase after two weekly doses at 30 µg/kg. I'm starting with DAC, weekly dosing of the long-acting version, and monitoring side effects closely. If they're intolerable, I'll switch to no-DAC + Ipamorelin, daily. Here’s my protocol, taking it easy on the dose, since DAC peptides are long acting: Week 1 1.2 mg CJC-1295 DAC Week 2 2.4 mg (or switch to no-DAC + Ipamorelin if side effects demand it) Weeks 3 and 4 2.4 mg CJC-1295 weekly + 0.25 mg tirzepatide, twice weekly Measuring everything: • Weekly blood: IGF-1, GH, GHRH, fasting glucose, insulin, HOMA-IR, ApoA1, ApoB, prolactin, cortisol • Continuous CGM across all 4 weeks • Continuous core body temp (eCelsius capsule), weekly • Sleep, HR, HRV: 24/7 I'll post results as they arrive.

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Demon4932
Demon4932@Demon4932·
@shahzadmkayani @midaqih Having watched most of the stream with this instructor, he was pretty good. This is just 1 clip taken out of context.
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Shahzad Kayani
Shahzad Kayani@shahzadmkayani·
Instructors like this are the worst, we should try and make it a pleasant experience for new shooters. You’ll notice that most of the guys who are really experienced and have a decent shot are the most chill / patient, it’s the guys that woke up one day and took a range safety officer course who think they’re badasses.
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midaqih
midaqih@midaqih·
Range instructor got MAD at Clavicular after realizing he wasn’t himself and wasn’t handling things properly 😳
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GitHub Projects Community
GitHub Projects Community@GithubProjects·
The official manager to mod and block ads in popular apps.
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BloctoApp (🐚,🐚)
BloctoApp (🐚,🐚)@BloctoApp·
[The End of an Era: Important Announcement Regarding the Future of Blocto] To our valued community, After five incredible years serving over 2 million users, it is with a heavy heart that we announce the sunset of Blocto Wallet services. Since Day 1, our mission was simple yet ambitious: to craft the most newbie-friendly wallet in the world, one capable of onboarding millions to Web3. And together, we achieved that. Back when EOA wallets were the only option, Blocto pioneered email and social login solutions, along with our SDK, making blockchain interaction easier than ever before. As the earliest supporter of Flow, Blocto built the ecosystem’s major infrastructure, including Blocto Wallet, BloctoSwap, Blocto Teleport, and BloctoBay. We also established the most utilized FLOW delegation node. We have worked alongside top-notch projects and served millions of you, and for that, we are immensely proud. The Difficult Reality However, focusing solely on building great products is not always sustainable. As the $FLOW price declined from nearly $40 in 2021 to below $0.30 today—a drop of over 99%—Blocto has been operating at a significant loss. For the past several years, we have absorbed over $5.5 million in losses to keep our services running for the community. Even as market conditions worsened, we upheld our commitment, ensuring that users' assets remained secure and accessible. But this could not last forever. Recognizing that our operating capital was running low, we began attempting to engage the Flow/Dapper leadership in June of this year. After 6 months of persistent effort, we have not been granted a single leadership meeting. Every email exchange took weeks, while we continued to burn through our remaining runway. During these months, we received neither explicit support nor the opportunity for a constructive discussion on a sustainable path forward. Now, we simply do not have the capital to continue absorbing these costs. We deeply regret informing our community of this outcome. Blocto’s journey as a wallet provider ends here. Service Changes & Critical Actions Required Please read the following details carefully, as they affect your assets. 1. Blocto Wallet, Swap, & Teleport are Sunsetting Effective December 18, 2025, at 7:00 PM PST (the sunset date), Blocto Wallet, BloctoSwap, and Blocto Teleport will discontinue operations. 2. Blocto Staking Service Remains Operational Please be assured that the Blocto Staking Service (our node) is unaffected and will remain up and running. Your staked assets are completely safe. To continue managing them, you only need to import your Blocto Wallet private key into another wallet service. There is no need to unstake your FLOW. Doing so would cause the loss of your FLOW staking reward. 🛑 Critical Actions Required Before Dec 18, 2025, 7:00PM PST: Withdraw Liquidity: If you have liquidity in BloctoSwap, withdraw all deposited liquidity immediately. Bridge Assets: If you hold tUSDT (Flow), go to Blocto Teleport and bridge it back to Ethereum immediately. ⚠️ Warning: Failure to complete these withdrawals before the sunset date may result in a permanent loss of access to these specific assets. For Custodial Mode Users: Action Required Before Dec 18, 2025, 7:00PM PST Migrate Your Wallet: To ensure the safety and control of your assets, you MUST manually export your private key by switching to Non-Custodial Mode before Dec 18, 2025, 7:00PM PST. How: Download the Blocto App, update to the latest version, and follow the in-app instructions to complete. Note: If you do not complete this manually before the sunset date, you WILL LOSE ACCESS to your wallet permanently. Security Warning: The Blocto team will never ask for your private key under any circumstances. Do not share your key with anyone. Only import your private key into trusted and verified wallet services. Please be aware that if you share your private key with a malicious party, your assets may be stolen, and we cannot recover them or provide support. Final Words We want to express our deepest gratitude to our users, investors, partners, and friends. Without you, Blocto could never have come this far. Even as this chapter closes, we want to say thank you. It is you who made this journey memorable. Sincerely, The Blocto Team
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choxonut
choxonut@cheepz98·
@Demon4932 @BattlefieldComm I got this playing gauntlet, my screen is black at the start of the match and even when I die it remains blacked out.
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Battlefield Comms
Battlefield Comms@BattlefieldComm·
Battlefield 6 Season 1 is Live! Jump into Battlefield 6 and start your Battle Pass progression now! Season 1 is live featuring new content, rewards, and fresh ways to play. Update 1.1.1.0 is already live across all platforms bringing new challenges, balance changes, and gameplay improvements. You might need to restart Steam for Battlefield REDSEC to become available. See what's new with Season 1 here: ea.com/games/battlefi…
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Torbis
Torbis@TorbisXD·
The Aurora Weapon Camo is so sick!
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HotGamerDude
HotGamerDude@HotGamerDudes·
I found the screen shot when someone got a dlore in my game and he was bottom fragging 11 years ago take me back😭
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Omilli💥
Omilli💥@OmilliTees·
Silver Surferl #1 is HERE‼️ ✨️👉Supported by @veve_official GIFTAWAY🎁🎁🎁 To be eligible just Like & Retweet. Join me on spaces as we collect this amazing comic. x.com/i/spaces/1YqKD…
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NVIDIA GeForce
NVIDIA GeForce@NVIDIAGeForce·
WIN THE NEXT GENERATION OF RTX ⚡ The #GeForceRTX50 sweepstakes is here & we're giving you multiple chances to WIN a GeForce RTX 5090! Here's your first chance to enter: ⚫ Like this post ⚫ Comment #GeForceRTX50
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Undead Sols
Undead Sols@UndeadSolsNFT·
How to burn 1 million $BONK? Simple we need only 9 replies with #LetsBONK here below 👇
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Demon4932
Demon4932@Demon4932·
@vitalyzdtv Have been watching since the first stream 😎
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VitalyTheGoat🐐
VitalyTheGoat🐐@vitalyzdtv·
Exactly one year ago, I jumped into streaming with no clue where to begin or how to make it work. I had doubts, confusion, and uncertainty, but I took action anyway. Fast forward to today, and I’m at the top of the game. For anyone out there hesitating or second guessing themselves, stop overthinking it. Just take that first step and trust the process. If I can do it, so can you. W Chat, W Mods, W Clippers, W Team, W Mom, W @capturedbydream, W @stevewilldoit,W @adinross, W @kick, W @Stake, W @StakeEddie, without you, it wouldn’t be possible. Thank you so so much 🚀
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spuno
spuno@spunosounds·
This is why you sell initials or take profit along the way‼️ Sure, you might miss out on a generational play, but for the day to day trades, this strategy has helped build my portfolio immensely.
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Demon4932
Demon4932@Demon4932·
@SergioCollects Put profile where community is Put market where profile was Put community where market was
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Sergio
Sergio@SergioCollects·
How to fix VeVe: STEP 1: Replace the profile tab with the marketplace
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Sergio
Sergio@SergioCollects·
Hey VeVe fam! Let’s give away this set of 4 sealed physical VeVe logo pins since I have several and only need one All you gotta do is: 1️⃣ LIKE & RETWEET 2️⃣ Follow my account @SergioCollects so I can message you if you win *tag someone for extra chances Good luck!
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