Bryan Johnson

On @netflix Jan 1 2025 is the year of don’t die

Livestreaming 5-MeO-DMT this weekend… what should I expect?

Two doses of magic mushrooms degraded my sperm count from the 99.6th percentile to the 77.7th. This may be a first-in-human observation. Context: we ran the most quantified magic mushroom (psilocybin) experiment ever conducted. We were asking if psilocybin is a longevity therapy. After seeing the data, we think it is (see reply post for the experiment summary). Also, like most things biology: the results are complicated. My data suggests that the magic mushrooms (psilocybin) negatively impacted my fertility markers. Before the first psilocybin dose my motile sperm count was at 99.6th percentile for men under 25 years of age, it dropped to 77.7% and partially recovered to 89.3% following the first dose, and second doses, compared to the same age cohort (numbers compare similarly to my age cohort as well). 3 days following my second dose (first dose 25 mg, second dose 28 mg) . Motility: dropped 51% . Total count: almost unchanged, dropped by 2% . Total motile count: dropped 52% . Normal morphology: dropped by 50% 20 days post 2nd dose, the pattern continued, with typical latent effects on total sperm counts Motility: recovered back to -2% of pre-psilocybin baseline: . Total count: dropped by 38%, latent effect. . Total motile count: remained inhibited at -39% of pre-psilocybin baseline, (despite motility normalizing, due to the total count drop) . Morphology normalized to -10% of baseline levels. Reduction in free testosterone might have contributed to the effect. While total serum testosterone increased by 30% 3 days following the 2nd dose (neither FSH or LH were meaningfully affected either), and continued to be at 11% above baseline, SHBG increased by 37%, SHBG binds testosterone and reduces its bioavailability and activity. My free testosterone (direct) showed 24% and 23% drops at 3 and 20 days post 2nd dose. In light of the neuroplastic, well-being, brain reset, and systemic metabolic and anti-inflammatory benefits, the trade-off is probably worth it. Especially considering that the magnitude of inhibition has no meaningful effect on actual fertility (total motile counts above 50 million are still on the safe side). This is a first-in-human observation, to our knowledge there is no published human clinical study demonstrating that psilocybin diminishes male fertility markers. General mechanistic evidence exists for recreational and psychoactive drugs possibly inhibiting fertility markers due to their effects on the hypothalamus-pituitary-adrenal axis and general hormonal reset.  Yet no direct evidence for psilocybin or other similar psychedelics inhibiting fertility markers exist. A potential mechanism for the immediate inhibition of motility could involve direct serotonergic signaling in sperm. Human sperm express multiple serotonin receptors, including 5-HT2A, and one recent study found that a 5-HT2A antagonist reduced sperm motility, suggesting that 5-HT2A may regulate motility. Psilocybin is known to bind 5-HT2A with high affinity.

Leeches to improve testosterone and sexual function. Will look into this and see if worth doing an experiment.

If you aspire, sleep. If you doubt, sleep. If you create, sleep. If you worry, sleep. If you love, sleep. If you hurt, sleep. Sleep.

It's the future it's possible that we'll use cells plus silicon for compute. In this experiment, scientists used a mouse brain organoid (brain-in-a-dish) to play a video game, showing living cells can solve digital tasks. Reaching 46% proficiency in a CartPole simulation.

I was in the HBOT chamber yesterday, at min 45, and remembered I’d swallowed a pill to measure my core body temp. Panic set in. Would this pill combust in my hyperoxyinatad tissues? Might this be my last moment? Surely, it will be one of these circumstances that finally gets me.

Eating chilis may be good for your memory. Capsaicin (from chilis) partially rescued the memory decline by restoring the gut-brain (vagus-hippocampus) communication. Aging microbiome disrupts the gut-brain communication and memory function.

I've cut my social media use by 50% and I feel 100% better. Did it with one simple rule: 2 hrs deep work for every hour on social media. You earn an hour on social media ONLY after two hours of deep work. The deep work must happen first.

One good conversation a day lifts you 10% higher on the global happiness scale.

You know how in the morning you dream big about the day. How hard you'll exercise. The focus you'll maintain. The emotional regulation to be cool. The discipline to do it all. Then, normally, it all goes to shit. Well today, a perfect day. Nearly never happens. Feels amazing.

@IndraVahan It was surprising to see how dramatically not icing the boys negatively affected fertility markers.

bryan johnson’s been real quite since this came out

Every system drifts toward disorder. Civilizations, ecosystems and our bodies.  The ones that survive learned to measure the drift before it compounds. That's Don't Die. Measure and correct drift.

Power to the people to solve disease, solve aging, and enhance themselves.

@scootykins men ejaculating 21x+ per month had a 20% lower prostate cancer risk compared to men ejaculating 4 to 7x per month

@bryan_johnson Jacking off and playing games

what are you up to today?

@bull_bnb Sorry to hear about that and glad that you're ok. What's now amazing is that with AI tools people can get very close if not better to diagnosing themselves than doctors. Hopefully you're getting routine blood and imaging done so you have the data to diagnose.

@bryan_johnson I am trying to find the cause of sudden heart attacks. I had one at the age of 34 like my LDA was blocked 90 percent. What tou think is the cause?

I got there. I was ready to do the rectal measurements for body temp. Then we found a pill solution. It's about the size of a jelly bean and passes through my GI track in around 24 hours. Measures core body temp every minute. Doing it next week. Excited for the data!

if you miss a nights sleep, can’t do anything bout that

if your hands get dirty you can just wash them