Med-X

CT-guided radiofrequency ablation combined with cementoplasty enables tumor control, pain relief, and structural stabilization in bone metastases, offering a minimally invasive treatment strategy. Recent work from Wentao Li’s team at FDU. rdcu.be/fik4A

Surface mechanical cues regulate macrophage polarization, chromatin accessibility, and the immune microenvironment, offering new strategies for immunotherapy and regenerative biomaterials. A timely review from Xiaoheng Liu & Yang Song’s team at SCU. rdcu.be/fik0i

Tuning LNP elasticity modulates cancer cell endocytosis and mRNA delivery efficiency, offering new strategies for RNA therapeutics and targeted cancer delivery. A notable contribution from Michael J. Mitchell’s team at UPenn. rdcu.be/fikXN

Multimodal energy ablation enables precise tumor destruction while synergistically activating antitumor immunity, offering new strategies for minimally invasive and personalized cancer therapy. A comprehensive review from Yueyong Xiao’s team at PLAGH. rdcu.be/fikTE

A microneedle colorimetric sensor enables minimally invasive early melanoma screening through in situ ISF extraction and LDH detection, offering a new strategy for portable skin cancer diagnostics. Recent work from Zhen Gu & Yuqi Zhang’s team at ZJU. rdcu.be/fikQL

Bioinspired bioadhesion draws from natural adhesive strategies in mussels, geckos, and octopuses to advance tissue repair, hemostasis, and regenerative biomaterials. An insightful review from Yu Shrike Zhang’s team at HMS. rdcu.be/fibd9

Engineered circRNA therapeutics improve RNA stability, reduce immunogenicity, and prolong protein expression, offering new opportunities for next-generation RNA medicines and vaccines. Review article by Prof. Wei Tao (HMS). rdcu.be/fibci

Temporal attention dynamically prioritizes visual information processing, shaping perception, decision-making, and behavior, offering new insights into brain cognition and intelligent perception systems. Review article by Dan Huang (SUSE). rdcu.be/fiban

Histone deacetylases and cell-cycle regulators orchestrate cell-identity transitions during Arabidopsis root regeneration hubs.li/Q04fBssl0 May featured research article from #MolecularPlant (@MPlantPCom) @nyuadcgsb

Generative AI is driving the integration of lesion localization and automated medical report generation, enabling more reliable and interpretable clinical image analysis. Review article by Prof. Dinggang Shen (ShanghaiTech University). rdcu.be/fhViX

Engineered macrophages carrying RvE1 suppress atherosclerosis progression through immune reprogramming, offering a new strategy for targeted immune cell therapy. Research article by Ansha Zhao (SWJTU). rdcu.be/fhVg6

Radiofrequency ablation achieves superior local control and long-term survival in ≤2 cm colorectal cancer lung metastases, supporting optimized patient-specific ablation strategies. Research article by Wentao Li & Xinhong He (FDU). rdcu.be/fhVeF

Machine learning in RNA structure prediction: Advances and challenges hubs.li/Q04f4kd80 Impactful biophysics research from @BiophysJ (@BiophysicalSoc)

🚨 Out today in Cell! @CellCellPress Path2Space: #AI that predicts spatial transcriptomics (ST) from H&E pathology, enabling spatial biomarker discovery in #BreastCancer at scale. 📄 doi.org/10.1016/j.cell… 🧵1/8

Alu repeat-containing RNAs spatially organize actively transcribed genomic regions around nuclear speckles dlvr.it/TSRVyd

Introducing Genie 3, a generative protein model that substantially advances the state-of-the-art for binder design, increasing in silico success rates by up to 20x on hard multimeric targets. It also debuts a form of inference-time scaling unobserved in other design models. 🧵1/8

If you want to know what 3′UTRs with long conserved sequence stretches do, check out our BioRxiv preprint doi.org/10.64898/2026.…. They form functional intermolecular 3′UTR-3′UTR interactions that enable co-folding of proteins to rapidly induce transcriptional programs.

Our review is now live @TrendsCellBio. We discuss how the DNA repair pathways c-NHEJ, MMEJ, and HR intersect at mammalian telomeres and the consequences for chromosomal instability. cell.com/trends/cell-bi…

Exciting new insights on CpG islands (CGIs) regulation by transcription factors (TFs)!  CGIs drive most transcription initiation with unclear regulation. We find that chromatin-opening TFs are key players—following a surprisingly simple rule. biorxiv.org/content/10.648… 1/9

Multimodal thermal therapy combining cryogenic and radiofrequency ablation enhances tumor antigen release and durable antitumor immunity, offering a new strategy for solid tumor intervention. Review article by Ping Liu & Lisa X. Xu (SJTU). rdcu.be/fhMhi