Melander Lab

Alexander Horswill @Horswill_Lab, Christian Melander @MelanderLab & co @CUAMCImmu_micro @NDscience report a structure activity relationship study of 3,4′-dimethoxyflavone for Staphylococcus aureus ArlRS inhibition in our latest issue Read the paper here🔽 pubs.rsc.org/en/content/art…

Congratulations to Annie and Ansley! Overcoming intrinsic resistance in gram-negative bacteria using small ... sciencedirect.com/science/articl…

Congrats Haoting and everyone who contributed! 6-Bromoindirubin-3′-oxime derivatives are highly active colistin adjuvants against Klebsiella pneumoniae - now published in RSC Medicinal Chemistry pubs.rsc.org/en/content/art…

Great job Ansley! Highlighting the 2020–2021 ACS Division of Medicinal Chemistry Award Winners pubs.acs.org/doi/10.1021/ac…

Development of small molecules that work cooperatively with ciprofloxa... sciencedirect.com/science/articl… Congratulations Katie and everyone who contributed!!

Synthesis, Stereochemical Confirmation, and Derivatization of a Clerodane Diterpene That Sensitizes Methicillin‐Resistant Staphylococcus aureus to β‐Lactam Antibiotics onlinelibrary.wiley.com/doi/abs/10.100… Congratulations Michael and everyone who contributed!! @QuaveEthnobot

We are so happy to have our rising fourth year, @ansleynemeth, back from her 5 week internship in Boston! She was working with Dr. Eddie Geisinger at Northeastern University. She was primarily working on Tn-seq with some of the compounds she synthesized.

Congratulations @ansleynemeth! Looking forward to recognizing the great work of our fellowship awardees!

Congratulations to our student @ansleynemeth for receiving the @AcsMedi predoctoral fellowship! Thanks to ACS MEDI Division and @genentech for sponsoring this award. We are excited for Ansley for this opportunity!

Melander Lab 2021 coming at you live! #NewProfilePic

Congratulations to Dr. Karlie Cox for successfully defending her thesis!

A beautiful column being run by one of our second years! We hope she gets a pure product!

Congrats to @AnaCheng06 of the @Wuestlab for making the most of the quarantine & writing a book! Thanks to @ACSPublications for inviting us to write the inFocus book Antibiotics intended to be a 5-hr course for senior UGs/1st yr grads. @laneygradschool pubs.acs.org/doi/10.1021/ac…

COVID patients and A. baumannii. Wish I could say I am surprised. But I am not. Increase in Hospital-Acquired Carbapenem-Resistant ... cdc.gov/mmwr/volumes/6… via @CDCgov

Latest paper from the lab. Congrats Alex, Sam, Pat and Orry! Thanks to @ErnstLabUMB A scaffold hopping strategy to generate new aryl-2-amino pyrimidine MRSA biofilm inhibitors - now published in RSC Medicinal Chemistry pubs.rsc.org/en/content/art…

"Antibiotic Resistance: A Matter of Time." Kick off World Antimicrobial Awareness Week 2020 with this powerful video from @FT. ft.com/video/7712f728…

Two papers from the lab included in this collection!

To all of my #antibiotic discovery peeps interested in #naturalproducts -- I'd love to brainstorm ways to leverage this work to fill the #antibiotic pipeline with more #plantbased scaffolds! #chemicalbiology @MelanderLab @whiteleylab @DaZtrain @gerryiidr @eric_brown_bbs + more🌺

New paper from #QuaveLab!! I'm so proud of this one! Our team worked tirelessly on this for >1 year to undertake the 1st major assessment of antibiotic compounds from plants! Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery pubs.acs.org/doi/10.1021/ac…

Call for papers on Antibacterial Drug Discovery. Click here for more information: ow.ly/rA8M50CbIEE