Vincent Libis

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Vincent Libis

Vincent Libis

@VincentLibis

Research group leader @INSERM - Paris Synbio - microbial natural products - drug discovery

Paris, France Entrou em Temmuz 2012
277 Seguindo544 Seguidores
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Vincent Libis
Vincent Libis@VincentLibis·
Interested in heterologous expression of large numbers of biosynthetic gene clusters? My focus over the past years has been to try to make this process more scalable. Have a look at this new approach, I used it to discover a new antibiotic: conkatamycin nature.com/articles/s4146…
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Aude Bernheim
Aude Bernheim@AudeBer·
So happy about this ! @VincentLibis is an amazing scientist and a great mentor. Join the Paris fun in microbiology and come discover new molecules 🧬💻🇫🇷🍷🥖🧫
Vincent Libis@VincentLibis

@ERC_Research is now backing my lab ! We are hiring bright minds at all levels interested in synbio/bioinfo/natural products. Join us in a beautiful space in the heart of Paris & leverage our massive biosynthetic gene cloning platform to discover new antibiotics and more !

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Vincent Libis
Vincent Libis@VincentLibis·
Many thanks to the anonymous reviewers, this is quite an honor
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Vincent Libis
Vincent Libis@VincentLibis·
@ERC_Research is now backing my lab ! We are hiring bright minds at all levels interested in synbio/bioinfo/natural products. Join us in a beautiful space in the heart of Paris & leverage our massive biosynthetic gene cloning platform to discover new antibiotics and more !
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Vincent Libis
Vincent Libis@VincentLibis·
Need to recover a specific plasmid from a pooled library of clones ? Using a barcoded vector and a dedicated CRISPRi strategy it is now possible to separate the clone of interest from the rest: nature.com/articles/s4158… 1st example of application here to recover (meta)genomic BGCs
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Helena Shomar
Helena Shomar@HelenaShomar·
My friend, now colleague/collaborator has started a new lab in Paris, on the hottest topic : high throughput cloning and heterologous expression of BGCs I might be biased, but this is what synbio needs. Check it out and come work with us !
Vincent Libis@VincentLibis

I just started a lab in Paris developing strategies to manipulate BGCs at a massive scale. DM if you are interested in the platform's capabilities or if you are excited in mixing synbio, bioinformatics and natural products discovery (open positions). A bit on how this started...

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Vincent Libis
Vincent Libis@VincentLibis·
We use synthetic biology to mine new drugs from microbial genomes. Aside from the tech, we try to involve the public to help us search for new genes through our citizen science initiative @ScienceALaPelle . People already sent us >1000 soil samples from all over France. More soon
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Vincent Libis
Vincent Libis@VincentLibis·
9 yrs ago I joined the Paris iGEM team as a PharmD student. We ended up winning the competition in 2013. Team members included future superstars @AudeBer @SynBio1 @HelenaShomar Today we are once again sharing the same floor, this time as PIs ! same stellar coworkers, same spirit
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Vincent Libis
Vincent Libis@VincentLibis·
Interested in heterologous expression of large numbers of biosynthetic gene clusters? My focus over the past years has been to try to make this process more scalable. Have a look at this new approach, I used it to discover a new antibiotic: conkatamycin nature.com/articles/s4146…
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Vincent Libis
Vincent Libis@VincentLibis·
@danudwary @MDMlab_Paris Partially yes, we are interested in studying biosynthetic gene clusters diversity here. But the overall project is also a pressure test for the scalable BGC heterologous expression pipeline we develop
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MDMLab
MDMLab@MDMlab_Paris·
Our lab is out celebrating the best of being a scientist: a publication, successful bachelor students, 1200 Streptomyces strains isolated in Paris in the past weeks... the results of a satisfying collaborative effort! Cheers to Science !
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MDMLab
MDMLab@MDMlab_Paris·
Hello world, we are very happy, as the first paper of our new lab has just been published @NatureComms. It’s about describing the anti-viral arsenal of bacteria and a tool we developed to detect all known anti-phage systems called DefenseFinder. nature.com/articles/s4146…
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Aude Bernheim
Aude Bernheim@AudeBer·
Stoked to report in @nature the discovery of prokaryotic viperins, which naturally produce diverse anti-viral molecules ! After providing us with antibiotics, bacteria might become sources of novel anti-viral drugs. (1/9) nature.com/articles/s4158…
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Jake Wintermute 🧬/acc
Jake Wintermute 🧬/acc@SynBio1·
Biotech needs big transformative change to better serve the public interest. I wrote a furiously radical manifesto about it. Add your name and join me? wintermute.bio/declaration
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Vincent Libis
Vincent Libis@VincentLibis·
While this targeted approach is far from detecting every biosynthetic gene in the soil, it seems that untargeted (shotgun) sequencing would miss the majority of the gene clusters we report here. If you want to try this approach yourself we would be happy to help.
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Vincent Libis
Vincent Libis@VincentLibis·
Interestingly, some of these unknown molecules are very common across the globe. For example one of these can be found in Arizona, Hawaii and Oregon samples, i.e. 3 of the 4 soils we looked at. We expressed its genes in the lab and called the new product Omnipeptin.
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Vincent Libis@VincentLibis·
A vast unexplored biosynthetic potential hides deep inside soil metagenomes. We developed a method to detect rare biosynthetic gene clusters and access their products: nature.com/articles/s4146…
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