Honored to have our latest MrTAC research article featured on the Cover of Cell Chem. Here, we develop the first endogenous MrTAC and decode the rules of protein degradability, expanding tissue-specific degrader modalities.
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Women in TPD & Induced Proximity
376 posts
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Women in TPD & Induced Proximity retweetou
Pour a glass of champagne AND red Bordeaux—Our newest work with @GSK and @scrippsresearch is out in @Nature, where we describe SB-405483, the first allosteric CRBN ligand which potentiates neosubstrate degradation. Congrats Vanessa and all authors! 🍷💫💐
nature.com/articles/s4158…
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@thewoolab She is so inspiring! Congratulations Dr. Woo on this well-deserved grant award.
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Women in TPD & Induced Proximity retweetou
Congratulations to Dr. @nurkocaturk on being awarded a @WomenInTPD conference scholarship to attend the 8th Annual Hanson Wade TPD and Induced Proximity conference in Boston! 👏👏👏
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Fantastic panel and discussion last night including @kdonovan1008 (DFCI) and organized by Lori Friedman (ORIC) at the AACR-NCI-EORTC Town Hall on "The Promise of Molecular Glues in Cancer Treatment: Will it stick?"
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From the @bmsnews team co-led by Lynda Groocock and Deborah Mortensen comes the story of developing a BCL6 oral degrader with pM potency and excellent TGI. Fantastic work everyone!
pubs.acs.org/doi/full/10.10…
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What can you degrade if you bifunctionalize the CRBN binder to an agnostic chemical library? Turns out a lot of proteins! Read this fascinating work below led by the talented @InesForrest , Ph.D and colleagues at Scripps on their approach using AgnoTACs.
pubs.acs.org/doi/10.1021/ac…
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Women in TPD & Induced Proximity retweetou
The Aug-Sept Journal Club is ready!! Thanks to our amazing editors: @DeLaCuadraBaste, @_nicolamurdoch, Qinghzi, and Michael. If you are interested in the latest TPD literature, have a look!
buff.ly/JQPQrXK
#openaccess #TPD #journalclub @UoDLifeSciences
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If you are in the Boston area at the end of October do not miss our free, in-person networking event on Wednesday, October 29th from 5:30-7:30pm! Thank you so much to @KymeraTx for hosting. Register below at this link:
eventbrite.com/e/women-in-tpd…
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Congratulations to the Woo lab on their new approach to gate activity using an O-GlcNac modification on the CRBN bifurcational!
Woo Lab@thewoolab
While a spoonful of sugar helps the medicine go down, glycosylated PROTACs are a nifty way to metabolically control PROTAC activity 🤩🟦🍬 Check out our newest work out now is @J_A_C_S 🫡 Congrats to Chace and all authors! 💐🎉🐱 pubs.acs.org/doi/full/10.10…
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Women in TPD & Induced Proximity retweetou
While a spoonful of sugar helps the medicine go down, glycosylated PROTACs are a nifty way to metabolically control PROTAC activity 🤩🟦🍬 Check out our newest work out now is @J_A_C_S 🫡 Congrats to Chace and all authors! 💐🎉🐱
pubs.acs.org/doi/full/10.10…
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Congratulations to Selina Zhang @Selina_Zh_
who has been awarded one of our conference scholarships to attend the Lorne Ubiquitin Conference in Australia! Read more about her and the exciting doctoral work in ALS she is doing below. #WomenInTPD
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Women in TPD & Induced Proximity retweetou
Pleased to share Dr Nur Kocaturk has been awarded a Cross-Sector Experience Award from @acmedsci
This funding will allow them to collaborate with Promega Corp to co-develop a new cellular ligand finding platform for intractable disease related proteins.
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Women in TPD & Induced Proximity retweetou
Our evolved and engineered CRBN derivative used to enrich and visualise C-term cyclic imide-containing proteins, aka "Cerebody," is now live and in stereo in @CellChemBiol!🫡🎉💛 Congratulations to everyone behind this cool work! Huzzah! sciencedirect.com/science/articl…
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Congratulations to Kate Stuart, Rebecca Teague, and colleagues at PhoreMost on their work towards more rational design of molecular glues! Many ways to augment the surface and binding capabilities of E3 ligases.
biorxiv.org/content/10.110…
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Improvement of a DCAF1 binder that can be applied to targeted protein degradation co-led by Serah Kimani, PhD at the SGC, University of Toronto. Congratulations!
Link below:
nature.com/articles/s4200…
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Congratulations to @kdonovan1008 and colleagues at DFCI on their work uncovering numerous interactors of CRBN glues!
Katherine A Donovan@kdonovan1008
🧩 New paper out in Nature Communications! "Unveiling the hidden interactome of CRBN molecular glues" Huge thanks to our incredible team and collaborators who made this possible! 📖 Read the full open-access article here: nature.com/articles/s4146…
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Women in TPD & Induced Proximity retweetou
We hope everyone is as in love with this cover as we are! 🤩
Ella Marushchenko@Ella_Maru
💚My New Cover for @thewoolab @Harvard 💙 This art illustrates the discovery that #cereblon, a key protein in the cell’s waste disposal system, recognizes small chemical tags called #cyclic_imides (shown here in green at the tips of proteins). These naturally form at the end of #damaged_proteins and resemble the structure of #thalidomide, a drug with a complex legacy… 📍Originally used as a sedative in the 1950s, thalidomide became infamous for causing severe birth defects when taken during pregnancy… Because it’s dreadful effects during pregnancy were not assessed during trails… Only decades later, it was found to bind #cereblon and alter its function. Today, thalidomide and its modern relatives are used in #cancer_therapies because they redirect cereblon to degrade disease-related proteins📍 The study shows that #cereblon doesn’t just respond to drugs like thalidomide, it also recognizes similar structures that arise during protein damage. These cyclic imide #degrons could be harnessed to design new treatments that guide cereblon to target harmful proteins! 🔗 doi.org/10.1021/acs.ac… #sciart #science #scientific_illustration #chemistry #medicine #ellamaru #sciencegirl #sci_artist #sci_design #cover #scientific_cover #medicalartist #phd #phdlife
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