Juan Du

High Yield Monolayer Graphene Grids for Near-Atomic Resolution Cryo-Electron Microscopy biorxiv.org/cgi/content/sh… #biorxiv_biophys

"Amgen said it was forced to make some changes to its R&D programming. Like many other companies, it is opting to close out its neuroscience research." biospace.com/article/amgen-…

@rigbylab's lab from @VAInstitute came to visit @CryoEM_PNCC for some data collection. They got to work with Harry, another PNCC SPOC, who was able to get them 3 structures in different conformations in 3 days. Productive visit!

Video abstract for our new paper with @RuiZhangWUSTL and @DutcherLab. So many hours of Skype went into this structure... youtu.be/lz4eVJxHdEQ

First paper from my lab after entering a new field. Great collaboration with @alanbrownhms and @DutcherLab! In this paper we use high-resolution #cryoEM to identify 38 ciliary doublet associated proteins including 33 #microtubule inner proteins (#MIPs) 😎 cell.com/cell/fulltext/…

Sweet new fold!

This is Willo. She likes to awoo while she eats. Tonight’s meal was worthy of a gentler, but perhaps more meaningful, second awoo. 13/10

The structural mechanism of TRP channel temperature gating is uncovered and critically involves membrane lipids. We propose that the temperature sensor is the transmembrane domain. Details@ nature.com/articles/s4159… sobolevskylab.org/structural-bas… cuimc.columbia.edu/news/images-of… @AppuKum74640209

Our first @biorxivpreprint is out: Structure of a BAF-like SWI/SNF complex in association with nucleosome. biorxiv.org/content/10.110… #cryoem #transcription

@yiweichang Congratulations Yiwei!🎊🎈🍾

Very grateful to be named Packard Fellow!

AMPA receptor Regulation by TARP

@DrRGJonesLab @AgiosPharma @RJDLab @jrfmricher @ImmunoMet Congrats!!!🎉🎊🍾🎈

Please check out our new paper on using 13C tracing to study T cell responses in vivo. Amazing work by Eric Ma and a great collaboration with @AgiosPharma @RJDLab @jrfmricher and Connie Krawczyk sciencedirect.com/science/articl… @ImmunoMet

Cryo-EM structure of the mitochondrial protein-import channel TOM complex from Saccharomyces cerevisiae. biorxiv.org/cgi/content/sh… #bioRxiv

Full length P2X7 structures by @mansoor_steven @craigky @CryoEM_PNCC and Alanna! Congrats!

Full length P2X7 structures! Congratulations Steve!!

Mechanism of gating and partial agonist action in the glycine receptor biorxiv.org/content/10.110…

@furuttini RIP🙏🙏🙏

Saddest day of my scientific career. RIP Kiyoshi.

Structure of a temperature-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii that has a unique architecture and 2-fold symmetry. Details @ rdcu.be/bQ07J sobolevskylab.org/structure-of-t… nature.com/articles/s4146… #CryoEM

Structure of the thermo-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii disq.us/t/3i89xc5