Roger Greenberg

New research out in @NatureComms finds that the BRCA1-A complex restricts replication fork reversal-dependent DNA repair in ATM deficient cells ft. @arindam_datta1, Yaroslav Morozov, Jinghan Qiu & @RogerRogergr (@Penn_CBIO) @PennGenomeInteg @BasserBRCA nature.com/articles/s4146…

Meet Ralph Weichselbaum, MD, Chair of Radiation and Cellular Oncology and a leading radiation oncology expert. Follow him for insights on oligometastatic cancer, translational research and advances in cancer care. @rweichselbaum @UChicagoRadonc ow.ly/JBTY50ZjM95

A $10M gift will accelerate the development of a new therapy aimed at treating retinal vasculopathy with cerebral leukoencephalopathy (RVCL), a rare genetic and fatal disease with no cure. @rvcl_research @miner_lab spr.ly/6013BEDbU9

We're thrilled to announce PCGI Postdoc, Arindam Datta (Greenberg Lab), has published work showing that the BRCA1-A complex blocks replication fork reversal to restrict DNA end resection, defining the molecular basis of chemotherapy response in ATM-mutated cancers:

@rweichselbaum @arindam_datta1 Thank you Ralph! You're too kind

@RogerRogergr @arindam_datta1 Roger you’re amazing. I’m gonna have to set aside sometime to read this one.

Congratulations to Arindam Datta @arindam_datta1 on publication of “The BRCA1-A complex restricts replication fork reversal-dependent DNA repair in ATM deficient cells”. nature.com/articles/s4146…

BRCA1-A enforces a restrictive chromatin state to suppress fork reversal in ATM deficient cells. This prevents genesis of resection substrates, implicating fork reversal as a key determinant of chemo-response in ATM deficient cells. Great collaboration with @vindigniLab

Excited to share our review of molecular regulation/dysregulation of the cGAS/STING pathway. Kudos to co-authors Min-Guk Cho, Rachel Lee, and Jayce Johnson for leading this effort! @UNC_Lineberger @UNC_BCBP

G&D's Editorial Board plays an important role in ensuring we publish cutting-edge research of the highest quality. We are pleased to welcome six new early-career investigators to our Editorial Board. Learn more about the journal: ➡️ genesdev.cshlp.org

I am pleased to share the final piece of work from my time in the Wolberger Lab. Led by undergraduate Yash Bhargava, we performed a benchmark of AF3 on nucleosome-containing structures. Thank you to @CWolberger for allowing me to build this project up! biorxiv.org/content/10.648…

@SanimRahman4 @CWolberger Congratulations Sanim and Cynthia!

@rweichselbaum @YSPTSPS You too Ralph!

@RogerRogergr @YSPTSPS Roger you are great!

Thrilled to announce that postdoc, Haoyang Jiang, has been awarded an NCI Pathway to Independence Award (K99/R00) for his project, "BLM-Driven Recombination at Alternative Lengthening of Telomeres and Non-Telomeric Sites." Congratulations Haoyang on this well deserved award!

@rweichselbaum @YSPTSPS Thanks Ralph!

@RogerRogergr @YSPTSPS Great mentor!!

Really exciting work from the #Binder/@DrORourke2 group @PennNSG + collaborators highlights how intracerebroventricular CAR-T doesn’t exert anti-tumor effects in isolation but is heavily influenced by the balance of specific cell populations in the CSF.

Congratulations to one of our PCGI trainees, Haoyang Jiang!

Like many scientists of my generation, I entered the cell death field inspired by the work that came from Genentech, especially from @dixitvishva , Kim Newton, and their colleagues. Their discoveries did more than define apoptosis, necroptosis, pyroptosis and inflammatory signalling. They showed us what rigorous, elegant, and transformative science looks like. They also demonstrated that deep, curiosity-driven basic research could thrive within biotechnology and change medicine. Watching these departures is therefore not just news. For many of us, it feels personal. Yet the cell death field has taught us an important lesson: death is rarely the end of the story. In biology, death creates opportunities for renewal, adaptation, and transformation. The scientific legacy built by these extraordinary scientists cannot be erased by a reorganisation chart. Their discoveries have shaped an entire field and inspired generations of researchers who will carry those ideas forward. This is not the end. #GenerationDixit linkedin.com/posts/gianmari…

@biorxivpreprint Identification of highly immunogenic endogenous dsRNAs from cellular MDA5 filaments biorxiv.org/content/10.648… @QinA2I @PennGenetics @RogerRogergr

A terrific perspective from Ivan Dikic linkedin.com/feed/update/ur…)

We are thrilled to announce an opening for a tenure-track assistant professor in PCMM, Boston Children's Hospital and Harvard Immunology! Apply by August 2, 2026.