0xso

4.1K posts

0xso

0xso

@0xsingletonly

applied ai engineer. looking for founding engineer roles.

Присоединился Nisan 2022
154 Подписки1.2K Подписчики
Закреплённый твит
0xso
0xso@0xsingletonly·
just wrapped up my latest side project- ai agents that play the resistance: avalon! built both rule-based and llm agents to see if ai can master social deduction, deception, and hidden info gameplay. how do you think they fared? 1/n
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0xso
0xso@0xsingletonly·
@iScienceLuvr Any tips to validate if there’s alpha in AI x psychiatry?
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Tanishq Mathew Abraham, Ph.D.
a surprising amount of people don't understand the difference between AI in biology and AI in medicine... i've had to explain it countless times in the past ~4 years AI in bio - models for DNA/RNA/proteins/cells, AlphaFold, GPT-Rosalind, etc. AI in medicine - models for clinical data, patients, clinicians, MedGemma, ChatGPT for Health, etc. Lots of frontier labs are investing heavily in the former. At @SophontAI and @MedARC_AI, we work on the latter.
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0xso
0xso@0xsingletonly·
@hthieblot I’ve been finding the algo posts give better short term engagement but less takeaways. Switching back to my timeline
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Hubert Thieblot
Hubert Thieblot@hthieblot·
It’s my most insightful tweets that gets the least view. Algo sucks
Hubert Thieblot@hthieblot

The best definition of Product-Market Fit for startups I ever heard came from @eshear when i worked for him at Twitch. Most founders think they have PMF, but they don’t. Not yet at least. Think of your startup like pushing a boulder on a steep mountain: Stage 1: The Sisyphus Phase You’re at the bottom, pushing uphill. It takes Herculean effort just to move an inch. The second you stop pushing (marketing, pushing new features), the boulder rolls back to zero. No momentum. Stage 2: The Plateau You’ve pushed it onto a flat ledge. If you stop pushing, it doesn’t roll back completely, but it doesn’t move forward either much. This is where most founders get stuck. In general, you get stuck here here without great retention and marketing you can repeat. They think this is PMF. It isn't. Stage 3: The Tipping Point Suddenly, the boulder starts moving without you. You see signups from a random user post that went viral. You can’t pinpoint where 200 new users came from. You get emails out of no where of serious customers that wants to buy your service. The market is finally pulling the product out of you. Stage 4: The Avalanche The charts go vertical. You have made it to the other side. Retention is so high that growth just happens. Stability breaks because you’re scaling faster than you can code and build systems in your company. You have unlimited capital and crisis to manage. You need to hire and fast. Every few weeks, something happens where you thought the company was done. The Reality Check: Only a tiny % of founders ever feel Stage 4. Even then, a hundred things can still kill you and some might say it's even harder to scale than to start, but at least you aren't pushing the boulder uphill anymore, it has real forward motion now. Not being alone helps A LOT with phase 1 and 2. I personally only hit true PMF twice: @CurseForge and Gamepedia. With CurseVoice, we fell into the Stage 2 trap. We reached 5M MAU, but the retention just wasn't there. We couldn't outgrow Discord because we were still "pushing the boulder" while they were riding the avalanche.

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0xso
0xso@0xsingletonly·
What are some large corporations that have deep intellectual honesty as well?
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0xso ретвитнул
Samay
Samay@Samaytwt·
Unpopular opinion: "AI makes everyone a developer" is true the same way "cameras makes everyone a photographer"
Samay tweet media
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Paras Chopra
Paras Chopra@paraschopra·
AI bois be like:
Paras Chopra tweet media
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0xso
0xso@0xsingletonly·
@systematicls Wait… you’re from Singapore? 😂
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sysls
sysls@systematicls·
My standard answer for anyone asking why the start-up ecosystem in Singapore isn't flourishing really comes down to institutionalized risk-aversion. In Singapore, there is a "standard" path that practically everyone goes through. From age 6 to age 24, there is an institutionalized path that you are more or less constitutionally and socially mandated to follow. If you stick within the confines of the path, you are "doing well". If you veer from this path, you get struck down as a failure. Ability to stick within the confines of the path is only a function of academic prowess. I've lived both sides of the world first as a traditional "overachieving scholar" and then dropping out of school once I decided to walk the path less traveled. The difference in attitude from society is stark. This breeds a mindset among most Singaporeans that there is a "correct" answer for all situations. You smell this fear of "being wrong" in all walks of life, at every layer, in all institutions. This belief system of thinking there is a clear cut answer to all situations is entirely at odds with what is required to invoke the dark alchemy of creating something from nothing. To create a start-up, you need to be radically comfortable with being wrong and being able to iterate ruthlessly towards the correct answers. The government however, WANTS to keep the current outcome. This mentality among society at large allows them to clip the left tails of failure, push the median up (we are, after all, highest GDP per capita in the world) and think that clipping the far right outcomes is a worthy price to pay. To be entrepreneurial in Singapore is to literally go against institutional and societal programming.
adriel@adrielyong

as i paid my singapore taxes last weekend i realized singapore will never be a great startup hub. because everything just works too well here. it takes me sub 5 mins to file my taxes. this would have cost thousands and way more hours in the US. ride hailing and micro mobility are capped because of great public transportation. healthcare is so cheap you don’t even think about trying to AI compare / navigate care

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0xso
0xso@0xsingletonly·
@xwanyex Creating something has come easier, deciding what to create hasn’t.
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wanye
wanye@xwanyex·
I don’t have to be convinced that LLM’s make programmers more productive. But where’s all the stuff? We’ve now had months and months of 100x or 1000x programmet productivity improvements. Where’s all the stuff they’re building?
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0xso
0xso@0xsingletonly·
Wearing @F1 team shirts is paying to be a walking billboard.
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0xso
0xso@0xsingletonly·
Weekends are way too short- barely enough cognitive space to think about tough problems.
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0xso
0xso@0xsingletonly·
Pick something that’s deeply intellectually interesting to yourself n
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0xso
0xso@0xsingletonly·
Zig when others zag.
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0xso
0xso@0xsingletonly·
When you’ve a hammer and everything looks like a nail
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0xso
0xso@0xsingletonly·
When you get one shot by AI and everything has to be “agents” 🤦‍♂️
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0xso
0xso@0xsingletonly·
@datagobes @heygurisingh I find that running multiple instances of CC breaks my ability to understand the code. I’m kinda back to one CC terminal + reviewing every change
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Gijs
Gijs@datagobes·
I’ve tried this challenge where I worked “AI-native” and with as much agent parallelism as I could cope. It may have been the longest hyperfocus ride I’ve ever been on but the crash was also hard. The information flow is quite taxing. Agentic burn-out may become a thing. Just me or people with similar experience?
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Guri Singh
Guri Singh@heygurisingh·
Holy shit. Anthropic engineers don't write code anymore. A new hire just leaked what's actually happening inside the company shipping harder than anyone in 2026: Nobody on his team has hand-written code in months. They run multiple agents in parallel and act like managers, not engineers. His exact words: "if you're just watching an agent code, you're already behind. that idle time should be spent spinning up another agent and directing it somewhere else." The mental model isn't "use AI to code faster." It's "you are the PM, the agents are your engineers, and your job is to keep all of them unblocked." He called it being "fully AI aligned" as a team and said it changes what's even possible to build. The productivity gap between people who think this way and people who don't is already enormous. And the proof is simple: Anthropic has shipped harder than any company in 2026. If you're still hand-writing code, you're not behind on tools. You're behind on the job itself.
Guri Singh tweet media
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Framework
Framework@FrameworkPuter·
We just opened up ordering in four additional countries: New Zealand,  Norway, Singapore, and Switzerland! You can order anything that is in-stock on the site now, though you may want to wait until you see what we're announcing on April 21st.
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