Frank Paul Mora

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Frank Paul Mora

Frank Paul Mora

@InTime_49

Retired Haskell programmer. Was pro drummer & still play hours/day. Science, Philosophy, Literature. DMs blocked unless shared interests.

New Mexico, USA Присоединился Aralık 2012
1.3K Подписки460 Подписчики
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Sáfárné Hatrágyi Henrietta
Sáfárné Hatrágyi Henrietta@HatragyiSafarne·
Feeding microbes to feed the Gut: inulin reprograms intestinal epithelial metabolism and proliferation through HIF1α 👇 #d1e292" target="_blank" rel="nofollow noopener">tandfonline.com/doi/full/10.10…
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Louisa Nicola
Louisa Nicola@louisanicola_·
The hidden drivers of Alzheimer’s are not in your brain New science shows Alzheimer’s may be shaped by an organ-brain axis, where the gut, lung, liver, and bladder influence brain inflammation. 1. In Alzheimer’s, immune changes outside the brain may help drive: - chronic neuroinflammation - blood-brain barrier breakdown - harmful microglia and astrocyte activation 2. The gut-brain axis is especially important: - Healthy gut microbes support anti-inflammatory immune balance - Gut dysbiosis can shift immunity toward Th17-driven inflammation - This may worsen brain immune activation and neuronal damage 3. Key protective gut metabolites like SCFAs help: - strengthen the blood-brain barrier - support regulatory T cells - maintain healthy microglia function 4. Other microbial signals, such as AhR-related pathways, may also help suppress excessive inflammation in both the gut and brain. The big takeaway: Alzheimer’s progression may be influenced not only by amyloid and tau, but also by system-wide immune dysfunction. The future of Alzheimer’s treatment may not stop at the brain, it may start with the body.
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ESC & iPSC News
ESC & iPSC News@ESC_iPSC_News·
Researchers show that endogenous VEGF signaling safeguards human primed pluripotency, maintaining stem cell self-renewal and preventing differentiation into trophoblast-like cells. 📕 @NatureComms 🔖 go.nature.com/4smiH1J
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Putrino Lab
Putrino Lab@PutrinoLab·
@chydorina @loscharlos Hi! We are slated for first-in-human mitochondrial transplantation this year. AND my announcement about the MMT therapy was 100% home-based. I’m excited to provide all sorts of options to all patients. My role is to build functional, actionable toolkits, not to sell magic bullets
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Benji Backer
Benji Backer@BenjiBacker·
Medellín, Colombia dropped its city's warming temps by a whopping 4 degrees Fahrenheit. How? They created "green corridors" of trees and plants throughout the built city. It cost $6.50 per resident, and will save the city millions of dollars each year. We need more of this!
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The Science of Parkinson's
Mitochondria in a capsule? Researchers demonstrate mitochondrial transplantation (via erythrocyte membrane encapsulation), rescuing mitochondrial defects in patient-derived cells & #Parkinsons mouse model cell.com/cell/abstract/…
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Frank Paul Mora@InTime_49·
@HatragyiSafarne Modest iron deficiency can actually promote Treg expansion and improve outcomes in autoimmune models like lupus.
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Martin Heinrich
Martin Heinrich@SenatorHeinrich·
Democrats are forcing a vote to fully fund TSA immediately. Senate Republicans should join us and vote yes to end this chaos. washingtonpost.com/travel/2026/03…
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Frank Paul Mora@InTime_49·
@HatragyiSafarne The treatment restored the Th2/Th17 immune balance, which is often disrupted in allergic conditions.
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Frank Paul Mora@InTime_49·
@AARustom There may be no real time but what we call "time" can be measured.
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A. A. "Alfie" Rustom
A. A. "Alfie" Rustom@AARustom·
You are not becoming who you will be. You are aligning with who you already are. A new essay on block universe physics, neural networks, and the strange possibility that the self at the end of your path already exists. Read here: aarustom.substack.com/p/you-already-…
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Aging Science News
Aging Science News@AgingBiology·
Senolytic treatment induces oligodendrocyte dysfunction and demyelination in the corpus callosum pnas.org/doi/abs/10.107…
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