RewitzLab

This study was supported by @lundbeckfonden, @novonordiskfond, and @Carlsbergfondet — we are grateful for their support. 🙏

New from our lab in eLife! 🧠 We uncover how gut inflammation signals to the brain through glial JAK–STAT signaling, revealing a cytokine pathway that links intestinal health to sleep. 👉 doi.org/10.7554/eLife.…

Why do we feel sleepy when sick, and how does gut health affect sleep? 🤒💤 Our new eLife study shows that gut inflammation signals to the brain to trigger sleep. 👉 doi.org/10.7554/eLife.… #Neuroscience #SleepResearch #GutBrainAxis

Researchers have discovered a cell surface receptor that is essential for adipose #tissue responding properly to #insulin. When the receptor is inactivated, the response to insulin is insufficient. However, a researcher says that it may be possible to stimulate the receptor – thereby protecting against the #development of type 2 #diabetes. #sciencenewsdk sciencenews.dk/en/recently-di…

We are thrilled to share that @eLife has now published our "reviewed preprint" on how signaling from the gut to glia connects intestinal inflammation to sleep in #Drosophila! elifesciences.org/reviewed-prepr… @HalbergLab @Colombani_lab @lundbeckfonden @novonordiskfond @Carlsbergfondet

Thrilled to share our work! Thanks to @NovoNordiskFond and @DFF_raad, we unveil how LGR signaling mediates crosstalk between muscle, neuronal, and adipose tissues, protecting against #insulinresistance and offering insights into #Diabetes and #Obesity. nature.com/articles/s4146…

We are excited to share our recent work on gut-to-glia communication linking intestinal inflammation with sleep in #Drosophila! Many thanks to @HalbergLab and Andersen and @Colombani_lab! @lundbeckfonden @novonordiskfond @Carlsbergfondet @UCPH_Research biorxiv.org/content/10.110…

Latest from the lab: What are the mechanism by which insects maintain systemic ion and water balance as they interact with their environment? Another great collaboration with @DenholmLab!annualreviews.org/eprint/FXMYNQH…

Online now! Glycolysis-derived alanine from glia fuels neuronal mitochondria for memory in Drosophila dlvr.it/SyTZ2L

Let's try this again - look's like twitter can't handle the video 😂. Really excited to share the lab's first Drosophila paper and it's a big one. Check out our preprint shorturl.at/gqrvO where we present the complete neural connectome of an animal circadian clock

New paper: Petsakou, A., Liu, Y., Liu, Y. Comjean, A., Hu, Y. and Perrimon, N. Cholinergic neurons trigger epithelial Ca2+ currents to heal the gut. Nature (2023). doi.org/10.1038/s41586…

Michael Ashburner (1942-2023). Rubin GM. Curr Biol. 2023 Aug 18:S0960-9822(23)01072-2. doi: 10.1016/j.cub.2023.08.029.

Our preprint on #Obesity-driven #InsulinResistance reveals a muscle-neuronal-fat axis adapting to high-sugar-induced obesity conditions by influencing insulin secretion & sensitivity in #Drosophila. @Halberglab biorxiv.org/content/10.110…

Our last review: Drosophila TNF/TNFRs: At the crossroad between metabolism, immunity, and tissue homeostasis J. Colombani & D.S. Andersen - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/18…

Curious about how some beetles have evolved to drink, not with their mouths, but with their rectum? Check out our latest Quick Guide in the current issue of @CurrentBiology. In collaboration with @RobinBeaven @DenholmLab sciencedirect.com/science/articl…

If you are interested in how genes are regulated in response to dietary sugar, please check out our recent publication 'Sugar-responsive inhibition of Myc-dependent ribosome biogenesis by Clockwork orange': cell.com/cell-reports/f… 1/

Fresh preprint! Collaborative work with Chris Wegener's lab looking at the release of clock neuropeptide pigment dispersing factor.

How do animals weigh competing needs to maintain nutrient and fluid balance? Check out our recent review in #BioEssays in which we aim to provide a framework for understanding the polymodal optimization of homeostasis in insects. Also, pretty pictures... onlinelibrary.wiley.com/share/EU9FPTNI…

Thanks @crisprflydesign! Nice #CRISPR clones showing that the TNF Receptor wgn plays an important role in lipid metabolism in the #Drosophila intestine. science.org/doi/10.1126/sc…

New paper: split-intein Gal4 provides intersectional genetic labeling that is repressible by Gal80. Ewen-Campen, Luan, Xu, Singh, Joshi, Thakkar, Berger, White, Perrimon. PNAS. 2023 doi: 10.1073/pnas.2304730120. Epub 2023 Jun 5. PMID: 37276389