LongGame Ventures

Even if you are "doing everything right" in terms of lifestyle you're likely to be facing ageing diseases in your 80s - @statto at #FoundersLongevityForum @LDNTechWeek Solving this goes beyond lifestyle into rejuvenation style treatments and medicines

Cell therapies have enormous potential in longevity and regenerative medicine more broadly. But why are they still so expensive and hard to scale? Read more from our CSO Partner, Manish Chamoli PhD longgamevc.substack.com/p/scaling-cell…

Exciting news - Vincere has teamed up with Beiersdorf, the company behind leading skin care brands like NIVEA and Eucerin, to develop mitophagy-enhancing molecules for anti-aging skin care! You can learn more and chat with the team at: linkedin.com/posts/vincere-…

1/n Fun journey continues: Our new @CellStemCell paper out on how the Inherent & Dormant Plasticity of mouse naive PSCs can be "Exaggerated" to Directly form ~E8.5 Transgene-Free (TF) Mouse SEMs & WITHOUT inducing 8-16-Morula-like "Embryo Founder Cells". cell.com/cell-stem-cell…

@slatestarcodex has written a great article on the burgeoning field of embryo selection, featuring our recently launched company @herasight. Scott has used the technology himself and gives an overview of the field - this is an essential read for anyone curious to learn more.

How can you use Reinforcement Learning to make better proteins and what does a “Move 37” moment in protein design look like? We’re taking a look at ProtRL: a framework for aligning protein language models to your desired distributions using reinforcement learning. Filippo Stocco from Noelia Ferruz' lab is telling us all about how it works, why reinforcement learning is important for protein engineering, and how these proteins perform when tested in our lab at Adaptyv.

The crossover between crypto and longevity folk seems confusing at first... Both require you to deeply question concepts that most people hold as unquestionable: money and death. Worth a listen to @brian_armstrong with @NiklasAnzinger podcasts.apple.com/gb/podcast/ep-…

In the sciences, the authority of thousands of opinions is not worth as much as one tiny spark of reason in an individual man. — Galileo Galilei

UK just might become a leader in longevity — watch this great speech in the House of Lords by @mrevgenylebedev:

Why do people avoid directly expressing the desire: "I don't want to die"? It's not just about disappointment: it will happen anyway, so why upset yourself? It's not just about becoming an outcast: people will think you're strange. The fear of death doesn't raise social status. It's about the need for a complete overhaul of one's worldview. Everything must be reassessed. We all consider people whose actions will lead to our death in the future to be bad. But we also can't call those who do nothing, leading to our death, good either. "I don't want to die" is a breakdown of moral principles, if, of course, this desire is overwhelming. "I don't want to die" is a true new ethic, where everything is subordinated to the struggle for existence. You must behave differently if you seriously don't want to die. Calls for the fight for life cause an unpleasant feeling that comes from any moralizing. All these considerations require energy, which the brain deems unacceptable. All these considerations take time to understand what to do. "I don't want to die" is a confrontational position. It's a demand for everyone to act against death. The struggle for existence is a confrontation with the world. Can we do without a struggle? Yes, it has been done before and turned out poorly.

@stuartacook1 What is the funding situation like currently for VVB? Will you be raising soon for human trails?

I’ll raise you: How about a clinical trial? We have engineered a super long acting and potent anti-IL11 for human ageing trials at vvb.bio. Faster to humans, not another 5 years in mice Needs investment, build out, approvable endpoints and not easy ++. But..

@annapanart Its an inevitability

Immortality is everything. It would be humanity’s most glorious, special and unique achievement, and finally paving the way to Type I, II, and III civilizations. WHY settle for a limited life? Life CAN be something entirely different. Dream BIGGER. ❤️‍🔥

Pet Longevity genuinely seems like it might be the best risk/return opportunity for allocating capital in the longevity space

@brady_h Theres a surprise

Vaping lowers your VO2 max.

@biogerontology Ok *facepalm* just looked you up and saw where you work...

@biogerontology Is this going to be changed by development of lower cost ways of conducting trials? I've seen some companies work on "in silico" type simulation of human trails with different molecules, to help reduce the time and cost

Biotech is not for the light hearted. Everyone is super smart but only a select few survive.

This paper will make waves in the aging research community and the results will need to be replicated (I would not fully believe it until I see ITP data) but looks very promising. IL-11 and downstream targets are very promising. Congrats to the team and kudos to Singapore! Source: nature.com/articles/s4158…

This new paper provides a potential explanation for why psilocybin has such a profound impact on alleviating depression... It indicates a long lasting reduction in self-focused thinking and rumination!

>90% of UK deaths are caused by ageing, so where do the parties stand on longevity science? I looked through the #GeneralElection2024 manifestos! @UKLabour: no mention @Conservatives: nothing @reformparty_uk: rien @LibDems: - @TheGreenParty: nope @theSNP: nada @Plaid_Cymru: zero

@Mangan150 For now exercise is the best life extension drug.. But soon we will go beyond that

Life extension is 90% low body fat and a decent amount of muscle.

@C_Angermayer How does this decline look if you adjust for diet (i.e. men in 2016 are more overweight than in 1999)

The decline in men's #testosterone levels is a grossly underreported and understudied issue, which: a) has severe, broad consequences on society, and: b) sheds completely new light on “enhancement therapies” such as TRT (testosterone replacement therapy). pubmed.ncbi.nlm.nih.gov/32081788/