Andrew Steele

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Andrew Steele

Andrew Steele

@statto

Longevity scientist / Author of https://t.co/b7cDbmWGKN / Presenter https://t.co/ChpWwP9GqY / Co-Founder and Director @longevityinit

Berlin, DE Katılım Mayıs 2007
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Andrew Steele
Andrew Steele@statto·
Ageless: The new science of getting older without getting old is out in paperback! ‘A tour de force of anti-ageing science’ – @thetimes ‘A fascinating look at how scientists are working to treat the aging process itself’ – @drsanjaygupta Buy a copy at andrewsteele.co.uk/ageless/
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Marc
Marc@Marc_Topaz·
@statto @Rainmaker1973 Ah Massimo. The thinnest-skinned "influencer" on the Internet. He blocked me, too, for the same reason. He wants followers, not accuracy.
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Andrew Steele
Andrew Steele@statto·
I can’t quote-tweet because the big man here blocked me for calling out a previous inaccuracy in a post. This one is even dumber than the one that got me blocked, great work @Rainmaker1973!
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Matt Kaeberlein
Matt Kaeberlein@mkaeberlein·
NAD probably doesn't actually decline with age. This is one of the problems in NAD-world that I've been warning about for years. I'm glad to see it finally reaching publication. nature.com/articles/s4225… The myth that NAD levels broadly change with age in humans and other animals has been propagated by some high-profile people in the field, both in the scientific literature (mostly review articles not real data, which should tell you something) and in the pop-sci podcast world. This has generated hundreds of millions of dollars in sales for NAD precursors and hundreds of millions of dollars in grant funding for those investigators. To be clear, NAD biology is real and important. There are likely specific disease states, tissues, or individuals where NAD availability becomes limiting and where interventions targeting NAD metabolism may prove useful. But that is very different from the much broader claim that declining NAD is a universal driver of normal aging in otherwise healthy people. The evidence increasingly suggests that NAD precursors like NR and NMN do not extend lifespan in mice under standard conditions and likely provide limited or no meaningful benefit to the average healthy person. This is a good reminder of how science should work. Strong claims require strong evidence, especially when they become the basis for major commercial industries and public health narratives. Aging biology is complex, and we need to be careful not to confuse plausible mechanisms with demonstrated outcomes.
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Andrew Steele
Andrew Steele@statto·
Everyone’s talking about falling birth rates. South Koreans had 30% fewer babies than the UN predicted just a few years prior. But the UN is also very *pessimistic* on longevity. Check out our new post on whether longer lives could alter our demographic destiny:
The Longevity Initiative@longevityinit

New post: Can longevity save us from a population crisis? We tried out @OurWorldInData’s new population projection tool to see if increasing life expectancy could save us from demographic decline: thelongevityinitiative.org/2026/05/longev…

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John Burn-Murdoch
John Burn-Murdoch@jburnmurdoch·
The bit that most likely _would_ snap back is the pure time use displacement part. But it’s hard to know how much of an impact that alone is having. Certainly at most it would be in the ~0.1-0.2 range Jesus notes.
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John Burn-Murdoch
John Burn-Murdoch@jburnmurdoch·
Excellent as ever from Jesus Some overlap w/ the thesis set out in my piece — that smartphones and social media are in large part accelerants, amplifiers and ‘internationalisers’ of social/cultural shifts that have been slowly unfolding for decades if not longer.
Jesús Fernández-Villaverde@JesusFerna7026

Smartphones are not the explanation for the recent decline in fertility. Instead, they are an accelerator of deeper forces already at work. Let’s start with the facts. Fertility is falling almost everywhere: in rich, middle-income, and poor countries; in secular and religious countries; and in countries with high and low levels of gender equality. The decline accelerated around 2014. So, no country-specific explanation will work unless you are willing to believe that 200 distinct country-specific explanations arrived at roughly the same time. Smartphones look like the obvious candidate: the first iPhone was released in 2007, and global adoption has been astonishingly fast. Economists understand the first major decline in fertility in advanced economies, from 6 or 7 children per woman throughout most of human history to about 1.8, that occurred between the early 1800s and roughly 1970, well before smartphones. The main drivers were a sharp fall in child mortality (effective fertility was rarely above 3 and often close to 2) and the shift from a low-skill, rural agrarian economy to a high-skill, urban industrial one. We have quantitative models that fit these facts well. Country-specific factors mattered too, of course. Proximity to low-fertility neighbors accelerated Hungary’s decline, while fragmented landowning structures accelerated France’s. But these were second-order mechanisms. This is also why most economists long considered Paul Ehrlich’s doom scenarios implausible. We forecast that fertility in middle- and low-income economies would follow the same path as in the rich, probably faster, because reductions in child mortality reached India or Africa at lower income levels (medical technology is nearly universal, and most gains come from handwashing and cheap antibiotics, not Mayo Clinic-level care). Much of what we see in Africa or parts of Latin America today is still that old story. But in the 1980s, a new pattern appeared. Japan and Italy fell below 1.8, the level we had thought was the new floor. By 1990, Japan was at 1.54 and Italy at 1.36. This second fertility decline began in Japan and Italy earlier than elsewhere, driven by country-specific factors, but the underlying dynamics were widespread: secularization, an education arms race, expensive housing, the dissolution of old social networks, and the shift to a service economy in which women’s bargaining power within the household is higher. The U.S. lagged because secularization came later, suburban housing remained relatively cheap, and African American fertility was still high. U.S. demographic patterns are exceptional and skew how academics (most of whom are in the U.S.) and the New York Times see the world. My best guess is that, without smartphones, Italy’s 2025 fertility rate would be about 1.24 rather than 1.14. I doubt anyone will document an effect larger than 0.1-0.2. Italy was at 1.19 in 1995, not far from today’s 1.14. The TFR is cyclical due to tempo effects, so I do not read too much into the rise between 1995 and 2007 or the decline from 1.27 in 2019 to 1.14 today. The direct effect of smartphones is not zero, but it is not, by itself, that large. Where social media, in general, and smartphones, in particular, matter is in the diffusion of social norms. What would have taken 25 years now happens in 10. Social media are not the cause of fertility decline; modernity is. But they are a very fast accelerator. That is why social media are a major part of the story behind Guatemala (yes, Guatemala) going from 3.8 children per woman in 2005 to 1.9 in 2025. Without them, Guatemala would also have reached 1.9, just 20 years later. Modernity, in its current form, is incompatible with replacement-level fertility. By modernity, I do not mean capitalism: fertility fell earlier and faster in socialist economies than in market economies. Socialist Hungary fell below replacement in 1960, and socialist Czechoslovakia in 1966 (both experienced small, short-lived baby booms in the mid-1970s). By modernity, I mean a society organized around rational, large-scale systems and formalized knowledge. Countries will not converge to the same fertility rate. East Asia is likely stuck near 1, possibly below, given its unbalanced gender norms and toxic education systems. Latin America faces the same gender problem plus weak growth prospects, so I expect something around 1.2. Northern Europe has more egalitarian family structures and might hold near 1.5. The very religious societies are probably the only ones that will sustain 1.8. All of this could change with AI or changes in population composition. We will see. But on the current evidence, deep sub-replacement fertility is the “new new normal.” Unless we reorganize our societies, better learn to handle it as best we can.

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Derek Thompson
Derek Thompson@DKThomp·
I'm seeing lots of "nooooo you can't calculate a compounding trend across more than a few decades, that's illegal analysis" comments, but consider the following facts—and they are all facts 1. Fertility decline toward the replacement level and below is already a multi-century trend. It is one of the most steady multi-century trends in the world, whether you think that's A MOSTLY GOOD THING or THE APOCALYPSE 2. If you're anticipating a permanent doubling of fertility rates in Spain, Thailand, Japan, Mexico City, or Korea (which are all in the 1s or below) you are the only one predicting something that's never happened before in modern history. 3. There has been no extended period of significantly rising fertility in modern history. The Baby Boom lasted like 30 years and was incredibly contingent and strange. 4. Jesus' point is precisely that history is often shaped by long-range trends that don't seem to make a difference at the order of months but that shape society on the order of generations. x.com/Dan_From_Reddi…
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Derek Thompson
Derek Thompson@DKThomp·
"I don't think we appreciate how big of a change [low fertility] is. I'm going to make a crazy forecast. Let's suppose Thailand keeps its current fertility rate of 0.8 ... for 200 years. Thailand right now has 63 million people. At the end of 200 years, it will be around two million people." "I'm sorry. Two million?" "Two million. How do you wind down a society of 63 million people into two million?" youtu.be/5F7_qa-XLBg?si…
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Peter Ottsjö
Peter Ottsjö@peterottsjo·
The ultimate test for AI × bio is aging. There is nothing more complex in biology. Now two of the top experts in the field say we are nowhere near a solution using AI. But they also provide encouraging ways forward. Let's take a look. (1/7) 🧵
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Andrew Steele
Andrew Steele@statto·
Poetic and insightful talk from @DrMorganLevine of @altos_labs on the data revolution we need to make AI work for longevity at @VitalistBay! My favourite quote: ‘Measurements we take form representations which are like shadows of the real biological “latent state”.’
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Andrew Steele
Andrew Steele@statto·
Great overview of the progress in treatments for specific sub-pathologies of the aging process from @KarlPfleger at @VitalistBay. Lots in the pipeline—many of which may not extend lifespan on their own, but are exciting in aggregate*! * misfolded protein pun intended
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Andrew Steele
Andrew Steele@statto·
‘The US government will soon be spending $6 trillion a year in over-65s. ‘But countries like Brazil, where I’m from, are going to get old before they ever get rich.’ – @RaianyRomanni kicking off @VitalistBay Day 2
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Antonio Regalado
Antonio Regalado@antonioregalado·
@statto I think i integrated over a whole bunch of posts happening at the same time that were similarly themed but picked yours to place my "reaction" on, partly because it was milder. some of the anti-death people are kind of intimidating i
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Andrew Steele
Andrew Steele@statto·
When you say ‘people’, do you mean me given that you quoted my post, @antonioregalado? Because that’s not what my post says! It says that they’re not in conflict, and I very rarely come across anyone who says they are and we should be pro-lifespan and anti-healthspan…
Antonio Regalado@antonioregalado

People are complaining about doctors promoting "healthspan" at the expense of extreme life extension. The myth of Tithonus is relevant here. Made immortal by a goddess, she forgets to give him everlasting youth. He ends up shut into a room unable to move and babbling endlessly

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Andrew Steele
Andrew Steele@statto·
@kaimicahmills @mkaeberlein You make a lot of assertions about ‘the field’ which don’t generalise. Matt and I didn’t ‘invite in supplements with open arms’, and we and plenty of other scientists talk about frontier science to extend lifespan *all the time*. Take aim at the grifters, not us.
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Kai Micah Mills
Kai Micah Mills@kaimicahmills·
what is silly is that you are missing that the healthspan narrative is the entire reason for that opportunism and greed why can a grifter selling supplements win in the longevity field? why is there any opportunity for that at all? because the field invited it in with open arms my field, pre-healthspan, was about frontier science to extend human lifespan, not lifestyle, exercise, and supplements but alas, transhumanism had too much "nonsense" for the Real Scientists™️ and here we are
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Andrew Steele
Andrew Steele@statto·
Can someone point me to a serious longevity science discussion where lifespan is promoted to the exclusion of healthspan? There’s loads of evidence outside supercentenarians too—diet, exercise, etc in humans, and most interventions in animals like rapamycin in mice extend both.
Eric Topol@EricTopol

Why is there such obsession with extending lifespan when the bigger issue is that average healthspan is 65 years and there are no data (except in super-centenarians) that longer lifespan = longer healthspan (known as compression of morbidity)?

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Kamil Pabis
Kamil Pabis@Aging_Scientist·
@statto No one wants their parents or friends to die, instead everyone wants to spend more time with them! Then suddenly when it comes to geroscience it is called an "obsession" with lifespan. Future psychologists and historians will marvel at these debates.
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Andrew Steele
Andrew Steele@statto·
@mkaeberlein Team (1) is particularly annoying because it’s like ‘do you think we didn’t think of that? It took you ten seconds!’ With (2), I think there’s a perception that ‘healthspan’ = lifestyle and supplements, which I find odd but maybe we have different social media feeds!
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Matt Kaeberlein
Matt Kaeberlein@mkaeberlein·
💯 The only people I ever hear complain about a supposed lifespan versus healthspan debate are (1) self-proclaimed 'experts' who actually don't know much about the field or the literature you reference and (2) immortalists/vitalists who think that talking about increasing healthspan detracts from attention that should be spent on bigger goals. The former are simply annoying but will always exist on the left side of the Dunning-Kruger curve. The latter, IMHO, are generally well-intentioned, but have been misled about where the biology is today and what is likely to be feasible in the near future.
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Linus Petersson
Linus Petersson@LinusPeters·
@statto @TravisLongevity I’ve literally never heard a single person promote lifespan in this sense (i.e. at the expense of super poor health)
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Andrew Steele
Andrew Steele@statto·
@pittiecoco Oh wow, thanks for explaining! I thought mice were just tiny, furry humans. I’d better rewrite my book in which I forecast that all the treatments will simply transfer across!!
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