POP-GEM Lab

🧵 New publication from the PGC Anxiety Working Group. Our GWAS meta-analysis of anxiety disorders is now published in @NatureGenet! 🔗: doi.org/10.1038/s41588…

New publication in @Nature. MVP EHR linked genomics enables ancestrally diverse analyses, uncovering ancestry independent signals, 100 plus new schizophrenia loci, and convergent neurobiology with global relevance. doi.org/10.1038/s41586… @timbigdeli @CChatzinakos @panos_roussos

New open-access Translational Psychiatry paper: multi-omic integration + drug repurposing to identify FDA-approved treatments for opioid use disorder. Led by POP-GEM’s @BToddWebb. Approach generalizable across complex traits & disorders. nature.com/articles/s4139… #OUD

(2/2)🔗 here: jamanetwork.com/journals/jaman…

(1/2) Congrats to @TeddyWroblewski and team on their new JAMA Network Open paper using @AllofUsResearch data! The study reveals racial disparities in post-TBI neuropsychiatric outcomes and highlights the impact of structural factors on recovery. @timbigdeli @NeuroChirGlobal

(6/6) Dr. @NSCorralFrias will discuss the LAGC-MDD’s meta-analytic GWAS efforts, followed by Dr. @PetersonRoseann remarks on the importance of including ancestrally diverse populations in psychiatric genomics. #WCPG2025 #LAGC #PsychiatricGenomics

(5/6) Dr. Diana Núñez-Ríos will present analyses of CNVs in Colombian, Mexican, and Puerto Rican cohorts (947 cases, 310 controls), revealing complex admixture patterns and genetic variants linked to MDD. #WCPG2025 #MDD

(1/6) We’re excited to present “Advancing the Understanding of Depression Genetics Through Research on Latin American Genomes” at #WCPG2025! 🌎✨ 📅 Mon Oct 20 | 9:45–11:15 AM 📍 Blue River 3 – Convention Center (1st Floor), Cancún Led by Drs. @PetersonRoseann, @NSCorralFrias🧵..

(2/6) Latin America has one of the highest global rates of MDD (~12%) yet remains underrepresented in psychiatric genetics. This session explores new findings addressing that gap through cross-ancestry research. #WCPG2025 #LAGC

Congratulations to #LanieMullins, PhD student @VCU_VIPBG, on receiving the Rising Star Award at #BGA2025 🎉 Her poster using #UKBiobank data linked immune system markers (MLR/NLR) to depression, with NLR emerging as a stronger predictor in older adults.

🚨 New paper out! In a collaboration across MVP, FinnGen & UK Biobank, we conducted a phenome-wide study of sex chromosome trisomies (SCT) in 1.5M participants. Findings reveal shared disease risks across SCT. 🔗 sciencedirect.com/science/articl…

🚨 Big News! Our lab has officially moved from X to Bluesky! 🌿💙 If you're on Bluesky, let’s stay connected—follow us at bsky.app/profile/popgem…, and we'll follow back!

🚨New paper alert!🚨 Using triangulated evidence, @Kirsten_v_H, @jmvink73 & team (@zoereed23, @Madhur_B_Singh, @hannah_sallis, @MarcusMunafo) find no bidirectional causal links between diet/physical activity & depression/anxiety. 🔬❌ 📖 Read more: doi.org/10.1017/S00332…

🚨 New paper in HGG Advances! 🚨 We evaluate imputation panel performance in 1,814 Pakistani individuals, highlighting the need for expanded reference panels in genetic research. Read more: cell.com/hgg-advances/f… @JiayiXu64425510 @arsalanhasan3 @PetersonRoseann @timbigdeli #GWAS

🚀New paper by @Madhur_B_Singh on smoking & DNA methylation via twin-based MR using @NTRscience data! Supervised by @mcneale, @jenny_vandongen, & Conor Dolan. Co-authors: @PetersonRoseann, @DanaLapato, @charles_breeze, @explodecomputer, @HermineMaes. 🔗 doi.org/10.1007/s10654…

Thrilled to share some amazing news— @Madhur_B_Singh, supervised by @PetersonRoseann & @mcneale, has been awarded @VCU_VIPBG 's Kenneth S. Kendler Award for Excellence in Predoctoral Research!

1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @CellCellPress. cell.com/cell/fulltext/… A thread 🧵: