Michael Rauh

692 posts

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Michael Rauh

Michael Rauh

@QMyPath

MD/PhD; Hematopathologist/Assoc Prof, Queens U, Personalized Myeloid Cancer Pathology & Research (QMyPath) #chip #mdssm #leusm #hemepath

Kingston, Ontario, Canada Присоединился Mayıs 2014
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Michael Rauh ретвитнул
Sinclair Cancer Research Institute
Sinclair Cancer Research Institute@QueensuSCRI·
Happy International Day of Women & Girls in Science! 🌟 Celebrating the brilliant minds breaking barriers, sparking innovation, & inspiring future generations to dream bigger. Here’s to curiosity, discovery, and the power of science! 💡🔬 #WomenInScience #GirlsInSTEM #IDWGS2026
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Yash Pershad
Yash Pershad@yash_pershad·
@rheumrob,@AlexBickMDPhD, & I are excited to share that our work is now out in @jclinicalinvest! CHIP epi studies underestimate the association between CHIP & disease using WGS vs deep sequencing. Many thanks to the co-authors, participants, & reviewers! doi.org/10.1172/JCI198…
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Robert Corty@rheumrob

Using a unique cohort of 10k doubly sequenced people in @VUMCDiscoveries's BioVU, @AlexBickMDPhD, @yash_pershad, and I investigated how well #WGS data really works for detecting #CHIP. medrxiv.org/content/10.110…. Thread below! 1/n

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Arndt Vogel
Arndt Vogel@ArndtVogel·
TET2-mutant clonal hematopoiesis enhances macrophage antigen presentation and improves immune checkpoint therapy in solid tumors @Cancer_Cell doi.org/10.1016/j.ccel… 👉TET2 clonal hematopoiesis facilitates response to ICI 🧐Interesting link btw CH & cancer, potential biomarker? @myESMO @ASCO
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Michael Rauh ретвитнул
JAMA Oncology
JAMA Oncology@JAMAOnc·
CHIP was associated with increased heart failure and ischemic cardiovascular disease risk after #cancer therapy in patients with solid tumors, especially among those with higher #chemotherapy exposure. ja.ma/3Nj5vuW
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Journal of Clinical Investigation
Journal of Clinical Investigation@jclinicalinvest·
Clonal hematopoiesis driven by Dnmt3a mutations promotes metabolic disease development in mice In this Research Letter, Bowen Yan @BowenyanYan, Olga A. Guryanova @gur_ola @UFHealthCancer @UF_Pharmacolo& team @UFMedicine report #ClonalHematopoiesis, an #aging related condition caused by mutations in the #blood system, promotes #obesity, and drives the risk of #diabetes and #MASLD in the context of a high-fat #diet: doi.org/10.1172/JCI197…
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Nancy Gillis 🆖☮️
Nancy Gillis 🆖☮️@nancykgillis·
📢 Online today: Ancestry-dependent patterns of somatic mosaicism and clonal hematopoiesis mutations in over 125,000 individuals reveal distinct cancer associations rdcu.be/eSROU. A huge feat with pretty figures, driven by #ChristelleColinLeitzinger. 👏
Nancy Gillis 🆖☮️@nancykgillis

🚨🚨 Our new manuscript is now available online! Co-led with the awesome @mingxiangteng Peripheral blood somatic mosaicism and clonal hematopoiesis across ancestry backgrounds medrxiv.org/content/10.110…

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Marco Buttigieg
Marco Buttigieg@marcobuttigieg_·
Happy to share that our work on TET2 CH in ICI therapy is now out in @CR_AACR! We found that TET2 mutations promote myeloid co-stimulatory programs and suppress T cell exhaustion, contributing to improved immunotherapy response! 🔗Read more here: doi.org/10.1158/0008-5…
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Alyssa Parker
Alyssa Parker@alyssa_c_parker·
CHIP variants are often discovered incidentally in liquid biopsy testing, but is plasma cell-free DNA reliable when CHIP variants are the desired finding? 🩸@BloodAdvances @AlexBickMDPhD 🧵1/12
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Shelley Herbrich
Shelley Herbrich@smherbrich·
Earlier this year, it was reported that CH was detectable in solid tumors (TI-CH) and associated with poor outcomes. In collaboration with @carisls, we found that patients with TET2-mutant CH had improved response specifically when treated with ICT.
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Shelley Herbrich
Shelley Herbrich@smherbrich·
Clonal hematopoiesis in solid tumors matters! I am so excited to share that my postdoctoral work studying the ways in which TET2-mutant macrophages can improve response to immune checkpoint therapy is out now at @Cancer_Cell! cell.com/cancer-cell/fu…
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UHN Research
UHN Research@UHN_Research·
Congratulations to @PMResearch_UHN's Dr. Robert Vanner, who leads a team awarded $1M through @BrainCanada and @SRC_CRS's 2025 Translational Research Grant in Brain Cancer! 🎉 🔗Learn more about the project focused on advancing #glioblastoma research: braincanada.ca/funded_grants/…
Brain Canada@BrainCanada

🚨 Big news in #braincancer research! Brain Canada & @SRC_CRS are funding 2 top teams: Dr. Robert Vanner & Dr. Sheila Singh with $1M each over 3 years. @CDCR_Mac @UnityHealthTO Read more ➡️ braincanada.ca/announcements/…

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Eric Topol
Eric Topol@EricTopol·
Primary Prevention of colon cancer. We don't measure CHIP (clonal hematopoiesis of indeterminate origin, blood stem cell mutation) but it is the one factor that helps predict who will benefit from low dose aspirin jamanetwork.com/journals/jamao…
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@NatureGenet @QueensuDOM @QueensUHealth @rheumrob @AlexBickMDPhD @jclinicalinvest @ArndtVogel @Cancer_Cell