Luca Rampoldi

🔬Just published in @asnpublications In a mouse model of #ADTKD-UMOD, moderate calorie restriction restores autophagy, reduces ER retention of mutant #uromodulin, and significantly delays kidney disease. journals.lww.com/jasn/abstract/…

This #ASNJASN study explored the impact of calorie restriction on Autosomal Dominant Tubulointerstitial Kidney Disease (ADTKD) caused by UMOD mutations. Read more, and explore #BasicResearch: kidney.pub/JASN1032

This work was supported by grants from @Fondaz_Telethon, @MinisteroSalute and @mur_gov_ (PE8–Project @Pe8Age_It: “Ageing Well in an Ageing Society” in the context of the National Recovery and Resilience Plan). #ADTKD #UMOD #calorierestriction #RareKidneyDisease

Big credit to the brilliant postdoc Mariapia Giuditta Cratere (and her resilience) and to the rest of the team 💪, Benedetta Perrone and Céline Schaeffer at @MyUniSR and @SanRaffaeleMI, and to our collaborator Barbara Canciani at Ospedale Galeazzi - Sant'Ambrogio.

🔬Just published in @asnpublications In a mouse model of #ADTKD-UMOD, moderate calorie restriction restores autophagy, reduces ER retention of mutant #uromodulin, and significantly delays kidney disease. journals.lww.com/jasn/abstract/…

The Italian Society of Nephrology expresses its deep sorrow for the passing of Prof. Claudio Ponticelli, a pioneer in nephrology and an outstanding scientist and mentor. Our heartfelt condolences to his family and colleagues. #RIP #Nephrology

@Boletta_Lab @ERC_Research Fantastic, this is a massive achievement! Well done and deserved Ale !! 👏👏

🎉Beyond happy to receive an #ERCAdG! @ERC_Research QtCilia studies a novel nutrient sensing role of #cilia (@NatMetab rdcu.be/dDTn3).We will study how #cilia sense glutamine(Q) and talk to #mitochondria to regulate #metabolism. In health and disease #ciliopathies #PKD

Congratulations to @Boletta_Lab and @Ong_Lab ! Well deserved 👏👏👏

Happy to share our latest work on UMOD: not just ultrarare or common SNPs! Fantastic collaboration with @lrampold, Celine Schaeffer, @MIKADOlab, @johnasayer and many more! @Kidney_Research @snf_ch

@peppebovajena @SandroSca Volevamo la costruzione dal basso porco...

@BranwenHennig @wellcometrust Congratulations Branwen !

#Ricerca - La nuova proteina ingegnerizzata da un nostro gruppo di ricercatori apre potenziali strade verso una nuove strategie terapeutiche rivolte alle distrofie muscolari. ow.ly/iJEP50F2XMU

Last May, we were the first to report the #cryoEM structure of #uromodulin, revealing that #zonapellucida domain proteins form filaments with a unique architecture (biorxiv.org/content/10.110…). Here's the definitive story! #UMOD #zp_module #zp_domain @karolinskainst @NTUsg

KDIGO is excited to announce Episode 1 of the Genetics in CKD Webinar Series: The Critical Role of Genetics in Rare Kidney Disease - Not Just in Rare Kidney Diseases, on Thursday, July 30th at 11:00 AM EDT. Register: tinyurl.com/y2flbm72 #kidney #ckd #genetics #nephrology

So here it is - the first long-awaited structure of a ZP module (AKA ZP domain) filament! Congrats to all my co-workers, and a truly fantastic collaboration with @WUBin10069342, @lrampold, Shigeki Yasumasu & Marta Carroni!!! #cryoEM #uromodulin #UMOD #zp_domain #zp_module

Come and join us @QMULBartsTheLon @blizard_inst ! Looking for a talented geneticis/genomicist to derive functional insights into obesity working closely with @EastLondonGenes! Thanks @Barts_Charity for supporting this post: webapps2.is.qmul.ac.uk/jobs/job.actio… Please RT!

Intense, engaging discussion on the use and abuse of social media in science communication and outreach with @Stephen_Curry at the @SanRaffaeleMi Division of Genetics and Cell Biology retreat in beautiful #castione_della_presolana

Great session on 3D chromatin dynamics. Andrey shows v elegantly the role of contact sequences outside enhancers and promoters #ESHG2018

Rare Disease Day 2018 is on 28 February! Join us on social media to #ShowYourRare - from face paint selfies to a Thunderclap campaign, there are many creative ways to take part: ow.ly/aJqS30iotCB