Zurab Alkhanishvili

New Gilead study in Science Translational Medicine: HIV can mutate to resist Lenacapavir, but the virus pays a high price. The M66I mutation reduces viral replication capacity to below 20% Read more on: shorturl.at/7Dflb #HIV #Lenacapavir #Gilead #Virology #Science

4/4 It’s a complex equation. We are essentially testing if a streamlined list maintains immunity or opens gaps. Whether this is a smart optimization or a risky gamble, only time (and data) will tell.

3/4What will the fallout be? It’s hard to say. Maybe... nothing? Since funding will reportedly still cover the "non-recommended" vaccines, access remains (in theory). But removing the official "Universal Recommendation" sends a strong signal to the public.

1/4 Major shift in US health policy: The CDC is cutting the childhood vaccine schedule from 17 to 11 diseases Hep B & RSV ➡️ High-risk only. MMR & Polio ➡️ Remain universal. The rationale? "International alignment," specifically citing Denmark. 🧵 #PublicHealth #CDC #Vaccines

New longitudinal study reveals current smokers face a 31% higher risk of all-cause dementia. The link is strongest for vascular dementia (RR 2.09), especially in men under 85. #Dementia #PublicHealth #BrainHealth #ScienceNews shorturl.at/8afen

The Nordic Diet is proven to lower premature death risk by 22% and boost sleep quality. Think fatty fish, root veggies, and canola oil. It’s the sustainable, cold-climate rival to the Mediterranean diet. 🐟 #NordicDiet #Nutrition #Science nationalgeographic.com/health/article… via @NatGeo

FDA approves Novo Nordisk's oral Wegovy.💊 Trials show 16.6% weight loss, potentially outpacing injections. A major win for Novo against Lilly in the $150B obesity market, offering a needle-free option for millions. edition.cnn.com/2025/12/22/hea… #Wegovy #FDA #Obesity #PharmaNews

3/3 If the jump happens, we have the science, but we need logistics to distribute it. That takes time. Time = Lives Reality Check: Don't panic. The chance of mutation is minimal; this variant has been "scowling" at us for decades.

2/3 It’s breaching barriers (cows -> humans). While it’s not spreading human-to-human yet, its mortality rate is 48-52% (vs COVID’s ~1%). If it adapts, a crisis is inevitable. The Paradox: We have a vaccine, but it’s limited. Nobody invests when "nothing is happening."

1/3 Two days. That is the exact window we’ll have to react if an H5N1 pandemic begins, according to a BMC Public Health simulation. Why care? H5N1 is now "enzootic" (constantly circulating) in new regions and is the main driver of the recent egg price crisis. 🧵

Prof. Derek Smith (Cambridge) labeled the new H3N2 variant a "Shift" due to its 7 mutations. In my opinion, this is more of a "Major Drift" rather than a classic shift. Either way, one thing is certain - a hard winter is coming. 🥶 #H3N2 #Flu #Epidemiology

Common synthetic chemicals (like pesticides & industrial compounds) may harm our gut health. 168 of 1076 tested compounds suppressed beneficial gut bacteria. Some bacteria even developed #antibiotic resistance. #Microbiome #Pesticides #Health eurekalert.org/news-releases/…

Shingles vaccine linked to dramatic drop in dementia deaths. New study in Cell shows vaccination reduced dementia-related mortality by ~30% over 9 years in patients with existing dementia. #Dementia #Science #Healthhttps://www.cell.com/cell/fulltext/S0092-8674%2825%2901256-5

New study in Science Immunology: Infants with RSV + allergic mothers face highest asthma risk. 🫁 Viral infection up-regulates Fc receptors, helping maternal IgG antibodies trigger allergic responses in the baby. RSV prophylaxis could prevent this. science.org/doi/10.1126/sc…

7th person cured of #HIV. Unlike most previous cases, this patient received stem cells that weren't fully HIV-resistant. This proves we don't strictly need rare CCR5 mutations for a cure. Huge for research. Source: nature.com/articles/s4158…

Researchers developing an intranasal nanogel vaccine for cervical cancer show promising results in mice & macaques. Unlike current HPV shots, this is therapeutic-aiming to treat existing tumors via mucosal immunity. A potential non-surgical future for preserving fertility. #HPV

Ex-UK PM Johnson oversaw 'chaotic' response to #COVID which led to more deaths, inquiry finds reuters.com/business/healt…

Nobel laureate Drew Weissman & team are testing a new mRNA vaccine to prevent allergies. Early mouse studies show it blocks allergic reactions. eurekalert.org/news-releases/… #Allergy #mRNA #Science #Health

Canada just lost its measles elimination status (held since '98). An outbreak in under-vaxxed communities has lasted > 1 year. The US is right behind them, tracking its worst year since 1992. #Measles #VaccinesWork #PublicHealth