Chrysanthi Kagiou

27 posts

Chrysanthi Kagiou

Chrysanthi Kagiou

@CKagiou

PhD student @Winter lab | CeMM

เข้าร่วม Ekim 2020
178 กำลังติดตาม74 ผู้ติดตาม
Chrysanthi Kagiou
Chrysanthi Kagiou@CKagiou·
Beautiful work, crucial for uncovering the mechanism of alkylamine degraders, helping the progress of our recently published work. Our complementary studies together with the new FBXO22-based PROTACs from Zhang lab (nature.com/articles/s4158…) have unclocked FBXO22 for TPD!
Cheryl Arrowsmith@CherylArrowsmi1

Published today, our fantastic collaboration with Lindsey James group, @BrianRaught, and Licht Lab. Thanks to the talented David Nie and John Tabor! nature.com/articles/s4158…

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Danette Daniels
Danette Daniels@danetteldaniels·
@doc_jlmeier My 11yr old helped me make this meme just for the two of you - my very first one! Hope you are enjoying this @CKagiou 🤣
Danette Daniels tweet media
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Chrysanthi Kagiou รีทวีตแล้ว
CeMM
CeMM@CeMM_News·
🔬 Targeted Protein Degradation: A new adapter molecule expands the therapeutic potential around the cell's waste disposal system, CeMM PI @georg_e_winter's team published a new study in @NatureComms : go.nature.com/3zn9Ia2 Read more ➡️ bit.ly/4cmwYn6
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Danette Daniels
Danette Daniels@danetteldaniels·
Congratulations @CKagiou and team! @KRHornberger and @doc_jlmeier - perhaps a new list needs to be started of E3s that cannot degrade BRD4?!😅🤣
Women in TPD & Induced Proximity@WomenInTPD

New manuscript led by @CKagiou along with colleagues at CeMM and MPI describing an alkylamine handle which covalently recruits FBX022 for targeted protein degradation. Perhaps equally impressive - it could not degrade BRD4 ☺️Congratulations Chrysanthi! nature.com/articles/s4146…

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Chrysanthi Kagiou
Chrysanthi Kagiou@CKagiou·
@KRHornberger @danetteldaniels @doc_jlmeier It could be a possibility, but we tested up to PEG4 which was the longest of all the linkers we had used so far. And for both FKBP12 and the two other targets, NSD2 and XIAP, shorter linkers worked as well. In any case target-to-target optomization would be the way to go.
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Chrysanthi Kagiou
Chrysanthi Kagiou@CKagiou·
This was the result of an amazing team effort! Special thanks to @jakobfarnung and @JoannaLiwocha from the Schulman lab for the biochemistry expertise, and Kevin Dong, Ka Yang and Joao Paulo from Gygi lab for the proteomics support.
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Women in TPD & Induced Proximity
Women in TPD & Induced Proximity@WomenInTPD·
New manuscript led by @CKagiou along with colleagues at CeMM and MPI describing an alkylamine handle which covalently recruits FBX022 for targeted protein degradation. Perhaps equally impressive - it could not degrade BRD4 ☺️Congratulations Chrysanthi! nature.com/articles/s4146…
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Chrysanthi Kagiou รีทวีตแล้ว
Sdelci Lab
Sdelci Lab@SdelciL·
We are very excited to share our story published in @MolSystBiol in collaboration with the Loizou Lab @LoizouJoanna, describing the role of PRDX1 as a nuclear-imported antioxidant enzyme for ROS scavenging after DNA-damage 🎉🎉🎉. embopress.org/doi/full/10.15…
Sdelci Lab@SdelciL

We are super excited to share our second preprint of the year in collaboration with the fantastic @JoannaLoizou Lab, investigating the interplay between cellular metabolism and the DNA damage response. 🎇🎆🎇🎆🎇🎆 👇👇👇👇👇👇 biorxiv.org/content/10.110…

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ค้นพบ

@danetteldaniels @NatureComms @SFB_TPDvienna @KRHornberger @ollie_lh @ElisaMHahn @mguarini1 @CherylArrowsmi1