Clock Foundation

@prof_horvath Very exciting... @prof_horvath is honing in on increasingly specific molecular mechanisms that underlie epigenetic clocks. It seems to set the stage to help answer key questions in the years ahead about causality, e.g. the degree to which is epigenetic ageing is programmed.

Part 1 of the trilogy on mammalian lifespan. 1️⃣ Rate of methylation change in bivalent promoters=1/Lifespan. 2️⃣ Young animals' rate is proportional to that of old animals linking aging to development. #EvolutionaryBiology #Aging #Epigenetics #Longevity biorxiv.org/content/10.110…

Thrilled to see a recent Nature Biotechnology article spotlighting the Clock Foundation, Steve Horvath, GrimAge, & rejuvenation trials. Physicians or consumers 🔬, our aging tests are available at ow.ly/eCRm50PJ8Nv! ow.ly/fG0K50PJ8Nw

Rapamycin is very unique in that ~90% of studies showed significantly increased lifespan in mice. Many clinical trials are also now active or enrolling. Find out more in our Treatment Review. myagingtests.com/rapamycin/

🌍Cardiovascular disease (CVD) is the top global killer. A recent Clinical Epigenetics study, including @prof_horvath, unveiled one of the first open-access databases of DNAm sites & genes linked to CVD. Conclusion: CVD and epigenetics go hand in hand. …lepigeneticsjournal.biomedcentral.com/articles/10.11…

Chronic stress accelerates aging, but how? A new study shows stress triggers increased cellular energy consumption or "hypermetabolism." This could pave the way for a new class of treatments targeting stress at the cellular level. ow.ly/il1g50OT8l0 @MitoPsychoBio

Discover the power of Nicotinamide Riboside (NR) in boosting NAD+ levels. Exciting studies in animal models demonstrate NR's remarkable ability to influence many age-related pathologies. Dive deeper into our Treatment Review for further insights. #NR #NAD+ myagingtests.com/nr/

Nicotinamide Mononucleotide (NMN) is an NAD precursor that's been making waves. Recent clinical data suggests it can raise NAD+ levels in humans without niacin's side effects. Learn more in our comprehensive Treatment Review. #NMN #NAD+ myagingtests.com/nmn/

Exercise is good for you, but does it make your muscles younger? Fascinating research on exercise training in humans & aged mice shows that muscle becomes epigenetically similar to OSKM partial reprogrammed tissue! @KevinMurachPhD #MuscleRejuvenation journals.physiology.org/doi/abs/10.115…

Niacin (Vitamin B3), the "OG" NAD precursor, can raise NAD+ levels in humans! It has shown moderate benefits in preclinical & clinical studies, albeit with more side effects than NR or NMN (e.g., flushing). Check out our Treatment Review for more: myagingtests.com/niacin/

Spermidine administration has been shown to induce autophagy and extend lifespan and healthspan in multiple model organisms both in vitro and in vivo. Find out more in our Treatment Review. myagingtests.com/spermidine/

Rapamycin is very unique in that ~90% of studies showed significantly increased lifespan in mice. Many clinical trials are also now active or enrolling. Find out more in our Treatment Review. myagingtests.com/rapamycin/

It's been nearly a decade since @prof_horvath published his seminal 2013 pan-tissue clock, which predicts age for nearly all human cell types and tissues, and has now been cited over 4,500 times. ow.ly/69pN50OCkwu #longevity #geroscience

Are you trying to choose the best longevity treatments? We've got your back! At the Clock Foundation, we've been busy studying new longevity treatments, and we're compiling the results to help you choose what to prioritize. myagingtests.com/news/

If you haven't seen it, a new version of GrimAge is now out! It works even better in both blood and saliva samples and adds two new epigenetic risk factors important for metabolic and cardiovascular health. ncbi.nlm.nih.gov/pmc/articles/P…

@biogerontology Haha - awesome!

Found this building in Toronto today. A nice idea for the @ClockFoundation HQ 😊

Do severe surgical stress, pregnancy, and COVID-19 increase biological age? Yes, but it can be reversed by recovery! Check out this exciting paper from @jpoganik @gladyshev_lab & @prof_horvath describing epigenetic clock studies in mice & humans. ow.ly/waZa50Oszt5

Highly accurate epigenetic aging clocks are now available for sea lions, walruses, and seals. Epigenetic clocks are starting to be used for wildlife conservation studies as a replacement for more invasive tooth and bone sampling. nature.com/articles/s4200…

Centenarian (≥100 y/o) clocks are now available in a collaboration between the Horvath and Church labs. Claims of extraordinary age have been recorded throughout history, but with only a blood sample, we can now put them to the test! link.springer.com/article/10.100…

Nature recently wrote an article "Turning back time with epigenetic clocks". A quote from Dr. Horvath captures the spirit of the Clock Foundation well: "Anybody who has an exciting study, I (we) love to get involved.” go.nature.com/3GaQDp9

Is there a reliable way to monitor anti-aging treatments in all mammals? Nature Communications has now published details of the Horvath Mammalian Array, a platform that can enable preclinical studies of new longevity treatments in any mammalian species. rdcu.be/cGKeg