COSR Lab

Discover how to reveal and harness CD39 for the treatment of #colorectalCancer and liver #metastases by engineered #Tcells reading our brilliant work recently published in @Gut_BMJ by Alessia Potenza, @balestrc @CosrLab @BoniniChiara and collaborators gut.bmj.com/content/early/…

🧬 "SurfR: Riding the wave of RNA-Seq data with a comprehensive Bioconductor package to identify Surface Protein Coding Genes" introduces SurfR, an R package enabling streamlined analysis of surface protein genes from #RNASeq data. Read more: doi.org/10.1093/bioadv… #DataAnalysis @aurora_maurizio @ASTascini

💻 SurfR, a comprehensive R/Bioconductor package for surface protein gene analysis from RNA-Seq data, is available with source code, tutorials, and use cases on GitHub: github.com/auroramaurizio… #OpenSource #ComputationalBiology #GeneAnalysis

Happy to present our #spatialomics 🔍🗺️work on #esophageal cancer @EACRnews Genomics multiOmics and computational biology meeting! Great program, inspiring talks and good friends! GiuliaLopatrielllo GiuseppinaArbore @OSanraffaele @COSRLab #cosmx

Kudos to @ValentinaGiansa for this and thanks to all people involved! 👇👇👇 Scalable Integration of Multiomic Single Cell Data Using Generative Adversarial Networks academic.oup.com/bioinformatics…

New lab pic? @ValentinaGiansa @LilloCarlin0 #retreatosr2024

Happy our SurfR package has been accepted in bioconductor! A a bioinformatics R package to surf the cells’ surfaceome starting from NGS data #bioinformatics #surfaceome #Rpackage @CosrLab @ASTascini @marcojmorelli github.com/auroramaurizio…

Please help me #RT this 2-years postdoc position #Bioinformatics / #DataScience at the crossing of single-cell #Genomics and #longreads sequencing. With @UniTrieste and @AreaSciencePark in Trieste! Fun work, people and science: more on #LinkedIn linkedin.com/jobs/view/3792…

Attention please! 📣Registration to the yearly event of our association @ERCinItaly are now OPEN! Register here: ercinitaly.eu/evento-ercinit… Be part of the Italian frontier research community!

Merry Christmas and happy new year from @CosrLab 🎅🎄⭐️🥂❄️ #Christmas2023

"This is an excellent study!" The rev said. Check out our peripheral #nerve #regeneration paper at authors.elsevier.com/c/1i5ab3BtfH5N… Congrats to the brilliant distinguished gentlemen Dario Bonanomi and Ganesh Bhat, dear @COSRLab colleagues @ilDepoMI and Santo Diprima, and all authors!

💥BIG PAPER ALERT💥 So excited to share our latest, out now @Nature! Here, we uncover a spatially confined interplay between subsets of IL-1b+ macrophages and tumor cells that fuels pathogenic inflammation in pancreatic cancer (1/n) nature.com/articles/s4158…

Join us at SR-TIGET in Milan! We are recruiting a PhD student to study how #telomeric damage contributes to defective #immunity as part of a fantastic international consortium @IMMERGE_MSCA_DN, a #MSCAction #DoctoralNetwork. @MyUniSR @Telethonitalia @SanRaffaeleMI. Apply below👇

36 datasets, 26 protocols, 1.7 million harmonized cells! First edition Human Neural Organoid Cell Atlas. Important work from @zhisong_he @josch_f Leander Dony @TreutleinLab @fabian_theis. Strong community effort @Sergiu_P_Pasca @GiorgiaQuadrato. #organoids @ETH_BSSE @IHB_Research

Un nostro nuovo studio apre nuove strade per lo sviluppo di immunoterapie innovative per curare il tumore del colon-retto. hsr.it/news/2023/otto…

Colorectal cancer: study of the tumor microenvironment opens up new possible immunotherapies. It has been demonstrated by researchers of the @sararaffaeleMI and UniSR, led by Chiara Bonino. Find out more : hubs.ly/Q023-2kk0

Check out the paper featured on the cover of this month’s Cancer Research: Preexisting Immunity Drives the Response to Neoadjuvant #Chemotherapy in Esophageal #Adenocarcinoma, by Arbore et al. bit.ly/45U1GjX

Two papers characterizing the critical role of CD8+ T cell subsets in COVID vaccination and infection - now in @NatImmunol! * @EJohnWherry lab (@markmpainter): nature.com/articles/s4159… * Our collab. w/Dan Littman's lab (@Bingjie_Zhang_+Rabi Upadhyay): nature.com/articles/s4159…

Excited that veloVI is out @naturemethods! Led by @adamgayoso & @PhilippWeiler7 w awesome @YosefLab, we combine deep generative modeling with a mechanistic single-cell transcriptional model for better RNA velocity analysis with uncertainty quantification. nature.com/articles/s4159…

Don’t miss this publication by @DCampolungo and Gabellini lab. Happy I had the chance to contribute to this incredible work unraveling DUX4-r role in acute lymphoblastic leukemia | @ScienceAdvances science.org/doi/10.1126/sc…

Acute lymphoblastic #leukemia is the most frequent tumor in childhood. Two studies from San Raffaele may help to identify further prognostic criteria earlier and better personalize treatments for this particular leukemic form. Read more: hubs.ly/Q022w06J0