Dave Rhee

Harvard researcher Joan Brugge says her work has the potential to prevent breast cancer, but she was notified last spring that her federal funding was terminated. “It was just like a gut punch. My knees buckled, and I had to sit down,” she says.

🧩 New paper out in Nature Communications! "Unveiling the hidden interactome of CRBN molecular glues" Huge thanks to our incredible team and collaborators who made this possible! 📖 Read the full open-access article here: nature.com/articles/s4146…

EndoMAP.v1 charts the structural landscape of human early endosome complexes nature.com/articles/s4158…

Check out our latest study @NatureSMB: Establishing a consensus model for #ubiquitin chain assembly by HECT #E3 ligases:#cryoEM structures of #TRIP12 forming K29-linked and K29/K48-branched chains! ❕Publication: nature.com/articles/s4159… @SamuelMaiwald @UniLeiden

#Technology Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes by @d_ogasa, @brumelillo, @bencravatt at @scrippsresearch @broadinstitute @harvardmed @MassGeneralNews dlvr.it/TGwBK2

We are very excited to share our recent preprint on the nuclear import mechanism of the proteasome, driven by the multivalent adaptor AKIRIN2! biorxiv.org/content/10.110… 🧵 (1/7)

Very excited to present the structural and mechanistic basis for stress response silencing by the monster E3 ligase SIFI. biorxiv.org/content/10.110…

Thrilled to see our work out in @naturemethods today! We applied prime editing to multiplexed dropout screens and benchmarked the tool’s ability to induce phenotypes when installing premature stop codons in essential genes.

Online now! Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes by @d_ogasa, @brumelillo, @bencravatt, et al at @scrippsresearch @broadinstitute @harvardmed dlvr.it/TGFYHz

Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases, now out @SpringerNature @NatureComms Awesome collaboration with @sagarchittori . @StJudeStructBio @MPI_Biochem @StJudeResearch #TPD #PROTAC #SchulmanLab rdcu.be/d0h2G

6 years of work + Over 2 years in review + 1 extremely talented graduate student @LeonaNease + Amazing collaborators = One extremely cool new mechanism that regulates metastasis through modification of the selenocysteine tRNA! nature.com/articles/s4301…

Check out our recent Opinion in @TrendsinPharma on chemical proteomic binding site determination for non-covalent compounds

Postdoctoral Position in @businolab Come join us as a #postdoc studying the mechanisms by which the ubiquitin-proteasome system (UPS) controls cancer. jobrxiv.org/job/dr-luca-bu…

Open season on FOXA1! Our paper with the Cravatt group is out today in @MolecularCell. Please check out the updated data, including a new discovery that FOXA1 ligands mirror the effects of a nearby prostate cancer mutation. authors.elsevier.com/a/1jxLO3vVUPRn… (1/2)

Principles of paralog-specific degradation engaging the C-degron E3 KLHDC2, now out @SpringerNature @NatureComms Awesome collaboration with @Richard_E_Lee and Taosheng Chen labs. @StJudeStructBio @MPI_Biochem @StJudeResearch #TPD #PROTAC #SchulmanLab rdcu.be/dWKpF

Thrilled to share our latest preprint describing discovery of the charged, metabolically activated molecular glue degrader engaging the basic pocket of the structural CRBN homolog, YPEL5 - a subunit of the giant GID/CTLH E3 ligase!!! biorxiv.org/content/10.110…

@sshaolab @HHMINEWS @HarvardCellBio Congrats!!!

Excited to join the @HHMINEWS community - made possible by talented lab members, current and former, and amazing colleagues at @HarvardCellBio and beyond!

@WalterWChen1 Congrats!! 🎉

15 years later, this physician-scientist has finally completed all his clinical training 🥳 Looking forward to a fulfilling career in neonatology taking care of our smallest patients and helping parents navigate that journey.

Excited to share our new paper @PLOSGenetics that reveals how Shh signaling promotes myosin II activity to regulate tooth morphogenesis in mice! doi.org/10.1371/journa…

Very pleased to share our latest work on substrate identification of deubiquitylases, led by @VRossio, in collaboration with @PauloLabMS @GygiLab, available @CellChemBiol. Link below is active until July 17. authors.elsevier.com/c/1jA778jWWJxL…