West Laboratory

Work led by Arpine Sokratian in Andy West's lab unveils the structural underpinnings of alpha-synuclein pathogenicity: Mouse alpha-synuclein fibrils display unique features compared to humans, impacting disease models. More here: doi.org/10.1126/sciadv…

Interesting: @DukeWestLab @LashuelLab & collaborators report the first atomic structure of mouse α-synuclein fibrils, but find altered packing arrangements,⬇️hydrophobicity, &⬆️fragmentation sensitivity & weak immunological responses (vs human a-syn) science.org/doi/10.1126/sc…

New paper from @DukeWestLab et al present an ultra-sensitive version of a SiMOA (single-molecule array assay) for measures of LRRK2 kinase activity in serum linking #Parkinsons severity to peripheral inflam.; Accurate measures of pT73-Rab10 to total Rab10 …arneurodegeneration.biomedcentral.com/articles/10.11…

#Cover: Gut mucosal cells transfer α-synuclein to the vagus nerve: buff.ly/3RyFyaH The image shows α-synuclein (red) emerging from an enteroendocrine cell (green) onto a vagal neuron (turquoise). @DukeHealth #Gastroenterology #Neuroscience

New research from @DukeWestLab & collaborators reports that anionic nanoplastic contaminants potently precipitate the formation & propagation of #Parkinsons-associated α-synuclein protein fibrils, through a high-affinity interaction NAC domains in α-syn science.org/doi/10.1126/sc…

Nanoplastics Create an Environment for Parkinson’s To Develop, Study Suggests | Technology Networks technologynetworks.com/applied-scienc…

Congrats to Amber!!, Our amazing undergrad researcher off to begin her career in medicine

Congrats to Jon Lin!!, Honors undergraduate researcher who will be starting his program in data science in a few weeks @NCState

Recent Duke Neuroscience honors Graduate, Deney Li, researcher extraordinar, will be heading our @MichaelJFoxOrg biomarker research project as a post-bacc! So happy she can stay on!

Our undergrad researcher Grace, headed for @UW_MSTP , go get em!

Congrats to Nicole!!, our post-doc headed to @VividionRx shake up the Early Discovery program!

Congratulations to Zhiyong!!, Our famous K99/R00 awardee and incoming tenure track Assistant Professor in Cell Biology, #UABSOM #GoBLAZERS

Shoutout to our grad student Samuel Strader publishing an excellent review! The interplay between monocytes, α-synuclein and LRRK2 in Parkinson's disease portlandpress.com/biochemsoctran…

Congrats to the West Lab 2023 Graduates!! Moving on is bittersweet for us, but what a great job in the lab, you will be missed 🥲

Interesting new commentary from West and Schwarzschild on LRRK2 inhibitors for PD and their journey through the pharma "Valley of Death." #LRRK2 #Parkinsons @DukeWestLab …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md…

@biorxivpreprint Rab12 activation controls pT73-Rab10 levels

Genome-wide screen reveals Rab12 GTPase as a critical activator of pathogenic LRRK2 kinase biorxiv.org/cgi/content/sh… #bioRxiv

@ASAP_Research @AsapLiddle retreat wrapped up today…what great science was discussed 🤓😍!!!

College life in a research lab: two students @DukeNeuro weigh in on how they got here, what they're learning and where they hope to go bit.ly/3fqfZZ4 @DukeWestLab

Celebrating Halloween at the lab 🧟🧚🏻‍♂️🧙