Fermata

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Binge drinking is fueled by a vicious cycle of brain injury, suggests this 2023 prospective MRI study: pubmed.ncbi.nlm.nih.gov/37323647 Binging on #alcohol raises cortisol, shrinking brain regions that manage stress and self-control, leading to more binging. #soberliving #alcoholism

Saffron worked just as well as SSRI #antidepressants for #anxiety and #depression in this analysis of 4-8 trials: pubmed.ncbi.nlm.nih.gov/38913392 But before we get too excited, these are small trials, and SSRIs have small effect sizes anyway. How to use saffron: chrisaikenmd.com/supplements

Hey readers...I'm a best selling new author. My book, "inessential pharmacology" is... #1 pharmacology #1 depression #1 humor: Doctors and Medicine On New releases charts on Amazon right now. amzn.to/3RXn03G

Our new and improved website went live today. Check it out: fermatahealth.com!

Getting ready treat #PTSD with PRISM @FermataHealth

While we mainly specialize in neuromodulation at our practice, we are fans of doing what works, especially for refractory mental illness. Please check out the work of this org and others like @GeorgiaEdeMD and @ChrisPalmerMD on this #WorldBipolarDay

@burtontabaac Thrilled to be part of this team! @ScottMuirMD

I am very excited to share that The American Journal of Therapeutics has published our Special Issue on Psychedelic Therapy: A Primer for Primary Care Clinicians! These articles are aimed to educate physicians & clinicians on psychedelics as therapeutics lnkd.in/gRbAeZA6

The sections: Historical Perspective & Overview Lysergic Acid Diethylamide (LSD) N,N-Dimethyltryptamine & Ayahuasca Psilocybin Ibogaine 3,4-Methylenedioxy-methamphetamine (MDMA) Ketamine The Strengths, Weaknesses, Opportunities, & Threats of Psychedelic Therapeutics

This comprehensive work was written by an accompaniment of coauthors from: @UniofOxford @uwsomwwami @KECKSchool_USC @StanfordMed @IcahnMountSinai @Columbia @unrmed @FermataHealth @AcaciaClinics

Superbowl Sunday at Stanford’s Experimental Therapeutics Hub 1) Making our hands twitch: A demo of SAINT – the rapid TMS protocol, personalized by prior fMRI analysis, making it much more rapid and efficacious than previous generations of Transcranial Magnetic Stimulation (TMS). They are FDA-approved and seeing 90% remission rates from treatment-resistant depression after an average of 2.6 days of treatment. More: ncbi.nlm.nih.gov/pmc/articles/P… 2) The brain scan on the screen guides the focal point of the magnetically induced activation, and the three retroreflectors on forehead and instrument provide registration, like the virtual filming rig we saw on the Avatar set: flic.kr/p/G6atX8 3) “Ultrasonic Ketamine Uncaging for Non-Opioid Therapy of Chronic Pain” — the next study. They have used focused Ultrasound (tFUS) to unlock an engineered molecular cage carrying a small-molecule drug so that the drug is only released in a precise region of the brain (to millimeter-scale). This can verify the mechanism of action in that particular brain region while avoiding systemic exposure and its side effects. They have shown this to work in animal models, delivering higher doses than systemic ketamine administration, and just to the targeted brain region. 4) Self-Hypnosis: We are most hypnotizable at the age of 6-10 years old (a developmental critical period). As adults, about 20% of us are highly hypnotizable and 20% are resistant. We had a similar distribution in Dr. Spiegal’s impromptu test of our crew (the outdoor photo). While we have genetic markers for hypnotizability, there are few correlates with other measurable traits — other than the subjective ability to be imaginative and disassociate from distraction. Hypnosis therapy has been effective for many disorders from anxiety to addiction (e.g., 20% cessation of smoking). You can take the 3-minute self-test here: reveri.com/hypnotizabilit… They have shown that they can increase responsiveness to hypnosis treatments with the SAINT TMS. And I suspect the same will be found in an upcoming study of psilocybin, given its potential to reopen critical periods (ref. Gül Dölen’s work: x.com/FutureJurvetso…)

Submit an inquiry on our website if you are interested in learning more!

Thrilled to share I’ve been chosen for @NatQualityForum ‘s Research, Development, and Solutions Stakeholder Advisory council on behalf of the @APApsychiatric and @OsmindHQ to help forge consensus on measurement and quality. bit.ly/3HwOlUz

Know someone who could benefit from accelerated TMS? We accept referrals from all over the world for treatment in our Brooklyn NYC office. Our founders talked all about it in this informative piece, including how @ScottMuirMD was helped personally by TMS in 2015.

We are so excited to be able to offer this to our patients!

Read more here: sciencedirect.com/science/articl…

Check out this new self-neuromodulation system for PTSD that uses biomarkers referred to as EEG-fMRI-patterns. Ours is one of the first in the U.S. to offer it! Inquire on our website. PTSD therapy without reliving PTSD experiences!

#stalking happens to doctors, especially psychiatrists, and as it's National Stalking Awareness Day, here are resources to help you navigate the problem