Michael Lab

Happy #420, today we release 22 pairs of high-quality chromosome resolved haploid #Cannabis #genomes (10 USDA lines) available to researchers through GRIN. All assemblies include gene models & repeat annotations @salkinstitute, …ub.s3-website-us-west-2.amazonaws.com/cannabis_sativ…

If you do #pangenomes check out this new tool PanKmer led by @ScienceGuyTony from @GenomesLab @salkinstitute really awesome to see this applied to many large datasets across different species so far!! #genomics

Awesome time at Salk and collecting Welwitschia at @TheHuntington with @jleebensmack @GenomesLab. More sex chromosomes !

A thread about using color as a design tool in science presentations. Color is a great tool to separate different categories of information, to highlight information, or to establish an emotional tone. 🧵1/20

PhD student @MaliaMoore23 in the lab discussing seagrass! @salkinstitute @Scripps_Ocean

@mattloose @nanopore May I make a suggestion for the software/gui/viz team? It would be really cool to have a real time tracker for Gb >50kb, Gb >100kb. Seems like an easy add on

Right - time for the other extreme... @nanopore kit14 and long reads... This run is about 3 hours in - so far looking pretty good for an ultra long run.

Kit 14 will allow users to tune their accuracy & output needs by modifying run conditions in the software. Early work has shown 99.6% raw read accuracy can be achieved at 28 degrees. At 34 degrees, 99.3% is possible whilst generating a high yield. Watch: bit.ly/3k2AR7n

Extreme field biology: miniaturised equipment for DNA extraction, sequencing and analysis in the wild (rdcu.be/cK7hP)

@ATJCagan Fantastic work, if you’re interested in looking at fishes, my post doc would be a good resource

Now the real fun begins, as we seek to understand precisely which aspects of ageing might be impacted by somatic mutation. To what extent do these trends exist beyond mammals? Can we learn more about genome maintenance from studying long-lived species? Stay tuned… [23/24]

Incredibly excited to share our paper ‘Somatic mutation rates scale with lifespan across mammals’ now published @nature. nature.com/articles/s4158… An illustrated & updated tweetorial… [1/24]

Lots of great comparative genomics tools on display by ⁦@mike_schatz⁩ —> also great to see a commitment to a deployment of tools to biologists via galaxy⁩ #AGBTAG22 ⁦@agbt⁩

Harnessing Plants Initiative: keys to carbon drawdown and storage #AGBTAG22 @salkinstitute @agbt … deep roots, bigger roots, and more recalcitrant carbon rich polymers

If you're interested in #wildcaught #fish #microbiomes, check out our @biorxivpreprint: "Fish microbiomes 101: disentangling the rules governing marine fish mucosal microbiomes across 101 species" biorxiv.org/content/10.110…

Took me about 10 #fish #genomes to get dialed in but finally making some ultra long dna and libraries — latest 83 kb N50 on #promethion @nanopore

Profs Joseph Noel + Todd Michael are showing how their research will help build a roadmap to preserve & restore wetlands around the world, using native plants that can withstand current and future climate conditions. @SpecNews1SoCal spectrumnews1.com/ca/la-west/new…

Continuing to celebrate #Blackhistorymonth2022 @salkinstitute with @blackatsalk

Welcome #PAG attendees! Virtual #PAGXXIX is happening now. Please be patient, as we are still working out the bugs. Virtual PAG XXIX Workshop Sessions Registration is still open at: ow.ly/8oH250Hqa3j We hope you join us.

Postdocs in computational, evolutionary, and disease genetics: apply to be in the Rising Stars in Genetics and Genomics Symposium at the U of Utah (May 11-12). We want to host creative, early career scientists to share their exciting science. docs.google.com/forms/d/e/1FAI…

Follow the action at #nanoporeconf @NanoporeConf 🧬

Accuracy often gets a lot of attention when talking about the most recent release of @nanopore chemistry. However, I think it is a game changer that now only 5 fmol of DNA is loaded onto the flowcell. For 10 kb DNA fragments that is down to 31 ng!!!