Sarah Hainer

Delighted to share Ben Patty's thesis research which represents an incredible amount of work, where Ben performed all the experiments and analysis presented in this massive body of work: biorxiv.org/content/10.110…. Ben is looking for a position - find him on LinkedIn!

Proud to be Canadian 🇨🇦 cbc.ca/news/politics/…

@TheRobertsLab1 @CellReports Thank you!

Fascinating new @CellReports paper from @HainerLab directly comparing the effects of all SNF2 family chromatin remodelers upon transcription of mRNAs, eRNAs, and uaRNAs in ES cells. sciencedirect.com/science/articl…

🧬🎉 Our new chromatin remodeling study is out: We reveal three states of human CHD1 and identify a novel "anchor element" that interacts with the acidic patch—conserved among remodelers. Our structures clarify mechanisms of remodeler recruitment! Link: authors.elsevier.com/a/1l2ik3vVUPVa…

Max Planck President Patrick Cramer @mpgpresident has written an open letter to the President of @Harvard, expressing his full support to the University & its stance against demands from the Trump administration to change its policies in order to retain federal funding @maxplanckpress

This support is highly appreciated! From personal experience: Transatlantic cooperation is a pillar of the scientific enterprise!

NSF GRFP #'s cut in half year-on-year 2022: 2193 awards, 1,377 Honorable Mentions 2023: 2555 awards, 801 Honorable Mentions 2024: 2026 awards, 1718 Honorable Mentions 2025: 1000 awards, 3008 Honorable Mentions The gutting continues apace. research.gov/grfp/AwardeeLi…

The U.S. National Institutes of Health’s recent decision to impose a 15% cap on facilities and administrative cost reimbursements is misguided and damaging, argue the authors of a new #SciencePolicyForum. scim.ag/41L2C9P

Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's a dedicated organization to oversee the servers] openrxiv.org 1/n

BioRxiv is the most important thing that happened in science publishing

On Valentine’s day, 15 Assistant Professors at NIH who had started their research labs in the last 2 years were fired. Their scientific expertise was built over 10-12 years of training, most if not all of which was supported by NIH.  The start up funds for their laboratories were

1. I feel like this is such obvious advice that it's taken for granted & so no one says this to young scientists but READ PAPERS, read all the papers. As you move up in your career you'll have a lot less time to do this. Read everything that appeals to you not just in your field

In our SETD2 paper, we visualize a novel nucleosome transfer intermediate during txn. It is the earliest intermediate visualized yet. In the intermediate, the histone chaperone FACT coordinates histone binding with a previously uncharacterized RTF1 helix: tinyurl.com/setd2

We are happy these studies provide new insight into coupling of nucleosome remodeling to transcription elongation. Sarah will be defending her PhD next week!

Excited by these findings we made some mutants in mES cells to ask if disrupting this interaction resulted in similar changes to CHD distribution and nucleosome positions. Perhaps due to complexity or resolution, we don't observe these changes.

Happy to share the latest preprint which is a close collaboration with @ArndtLab with a shared PhD student, Sarah Tripplehorn. Here we show a direct interaction between Chd1 and Paf1C subunit Rtf1 required for nucleosome positioning across genes: biorxiv.org/content/10.110…