Harms Lab

We’ve updated our BioRxiv preprint!🥳🧠Our study on co-pathologies and neuroinflammation now includes significant new findings that strengthen our conclusions! biorxiv.org/content/10.110…

COMING UP: Ashley S. Harms, Ph.D., will talk about "T Cells in Parkinson disease" as part of the @WorldPDCongress Research Spotlight 2025 series on June 3 at 10 a.m. CT! Learn more: buff.ly/FrtAmhL @UABHeersink

New WPC Blog Post T cells and Parkinson’s: What we know and where we are going by Ashley S. Harms, PhD @HarmsLabUAB Read here: worldpdcongress.org/home/2025/4/23… WPC blog made possible with support from Supernus_Pharma @BlueRockTx & CND Life Sciences. #Parkinsons #Scicomm

New research from @HarmsLabUAB & colleagues finds that overexpression of #Parkinsons-associated lpha synuclein can drive microbiome dysbiosis in mice, limiting diversity with age nature.com/articles/s4159…

A new review from @HarmsLabUAB & colleagues explores the emerging role of disease-associated microglia in #Parkinsons; "Investigating the spatiotemporal properties of DAM in PD could provide a strong baseline for comparison" across neurodegen. diseases frontiersin.org/journals/cellu…

Reminder: early bird registration is open for #MSA2025! 🔎 Don’t miss your chance to join the #global #MSA #community at this exciting hybrid event, happening 5/9-5/11, in #Boston or #virtually from anywhere in the world. #Register: missionmsa.org/internationalm…

Check out our latest preprint by grad student in the lab, Jhodi!

Abstract submissions are NOW OPEN for the T Cells in the Brain symposium TCB2025 tcellsbrain.org ! We are offering 10 travel awards to support national and international trainees ✈️ #neuroimmunology #tcells #Alzheimers #Parkinson’s # ALS #Epilepsy #MS

Yesterday I successful defended my thesis! Thank you to everyone to helped me get to this point. @HarmsLabUAB thanks for being the best co-workers a girl could ask for. Looking forward to continuing my scientific journey with @lesleylezhang at Yale this Fall 😊

Always happy to connect other Roadmap Scholars at the annual NEURAL conference. Thrilled to have the opportunity to share my research so far and so so honoured to have been chosen for the first place prize for oral talks! 🤞🏾🧠🥲 @UAB_NeuroRMS

Our latest preprint spearheaded by graduate student @njgallups highlights the role of brain resident CD8 T cells in MSA. biorxiv.org/content/10.110…

Check out my newest PrePrint from @HarmsLabUAB ! Tissue resident memory CD8+ T cells are present but not critical for demyelination and neurodegeneration in a mouse model of multiple system atrophy biorxiv.org/content/10.110…

By comparing the brains of pts with mild motor deficits ± nigral synucleinopathy vs. sporadic PD, Chu et al. provide evidence that initiation of nigrostriatal DAergic degeneration occurs independently of a-syn aggregation and can be tau mediated. tinyurl.com/yn3aanun

Thank you to @UABNews for this article summarizing our recent publication highlighting how IFNgamma plays a role in MSA progression. @njgallups uab.edu/news/research/…

Exciting news! My first first-author publication is out! 🤩 thank you to all the co-authors on the paper, especially @HarmsLabUAB for helping with this exciting discovery. actaneurocomms.biomedcentral.com/articles/10.11…

Congrats to grad student @njgallups on having this story out!! In this paper we show that IFNgamma contributes to pathology in a model of MSA. actaneurocomms.biomedcentral.com/articles/10.11…

By comparing the brains of patients with mild motor deficits ± nigral synucleinopathy, and patients with PD, Chu et al. find that initiation of nigrostriatal DAergic neurodegeneration occurs independently of alpha-syn aggregation and can be tau mediated. tinyurl.com/mvmk6ej6

Excited to have this one out! Read more about how innate and adaptive immunity are involved in Parkinson’s disease and how targeting both local and systemic inflammation will be a potential therapeutic approach in our review with @MaluTansey science.org/doi/10.1126/sc…

Additional congratulations to trainee poster award winners @nbaumgar, @cardosorodrigo2 (not pictured), and @jhodi!