Hiltunen Lab

Congratulations to Heli Jeskanen, who just won the best poster award related to PMG-AD project in the JPND meeting at Brussels! @UEF_Biomed @UEFNeuroInno @UEFneuroscience

Professori Annakaisa Haapasalo puhuu professuuriesitelmässään aiheesta "Otsalohkodementian translationaalinen tutkimus – molekyylimekanismeista tautibiomarkkereihin ja uusiin hoitoihin". #professuuriesitelmät #MeOlemmeUEF

Please check our latest findings related to effects of PLCG2 variant on AD pathology @UEFneuroscience @SuomenAkatemia Protective variant in PLCgamma2 mitigates Alzheimer's disease associated pathology via enhancing beneficial microglia functions biorxiv.org/content/10.110…

Excellent collaboration with Maria Jose Diogenes group! A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic physiology in Alzheimer's disease: Molecular Therapy cell.com/molecular-ther…

Outstanding funding decision for UEF Neuroscience Research Community!@UEFneuroscience @kuo_brain_mind uef.fi/en/article/eu-…

Pioneering study identifies six genetic regions associated with normal pressure hydrocephalus. Published in Neurology, the study is the first large-scale genome-wide association study related to NPH in the world. @GreenJournal @UEFneuroscience @KuopioNPH uef.fi/en/article/pio…

Uraauurtava tutkimus tunnisti kuusi normaalipaineiseen hydrokefaliaan liittyvää geenialuetta. Kyseessä ensimmäinen laajamittainen koko genomin kattava tutkimus NPH-taudista maailmassa. @UEFneuroscience @Pshyvinvointi @HiltunenLab @KuopioNPH @ClinmedUef uef.fi/fi/artikkeli/u…

Six novel gene loci identified in normal pressure hydrocephalus! @KuopioNPH @SuomenAkatemia @FinnGen_FI @UEFneuroscience Risk Variants Associated With Normal Pressure Hydrocephalus | Neurology neurology.org/doi/10.1212/WN…

Comprehensive discussion in Nadine Huber’s PhD dissertation - Nadine is doing great!😊 @HaapasaloLab @HiltunenLab @UEF_Biomed @UEFneuroscience

Cross-sectional study of plasma phosphorylated Tau 217 in persons without dementia medrxiv.org/content/10.110…

📢Publication of the first study investigating how genetic factors influence changes in neuroimaging markers during a 2-year multidomain lifestyle intervention Congrats to the authors👏 @drsaadmaan @HiltunenLab @TiiaNgandu @HilkkaSoininen @MiiaKivipelto alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

⁦Apoe4-tuplageeni ei aina aiheuta muistisairautta, vaikka lisääkin riskiä. Elintavat vaikuttavat, sanoo Mikko Hiltunen ⁦@kuo_brain_mind⁩ @UEFneuroscience⁩ ⁦@UniEastFinland⁩ ⁦@HiltunenLab⁩ ⁦⁦⁦⁦⁦@Kuopionkaupunki⁩ hs.fi/tiede/art-2000…

A new preprint from Mikko Hiltunen's group utilises FinnGen to show that the Finnish TYROBP deletion associates with an increased risk and earlier onset of dementia and Alzheimer’s disease in the monoallelic carriers.

Happy to share our recent preprint Monoallelic TYROBP deletion is a novel risk factor for Alzheimer's disease medrxiv.org/content/10.110… - Thanks to Henna and all other co-authors! @SuomenAkatemia @SigridJuselius @JPNDeurope @UEFneuroscience @UEF_Biomed

The #alzheimersdisease risk gene PLCγ2 acts in neurons as well as microglia, maintaining synapse number and excitability. @PasteurLille ow.ly/NnqW50RASxy

Great collaboration with Lambert lab - Neuronal downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease hallmarks biorxiv.org/content/10.110…

Kansainvälinen @alzassociation myönsi Neurotieteiden tutkimusyhteisön tutkijoille merkittävän rahoituksen hankkeeseen, jossa tutkitaan Alzheimer-riskiin liittyvien TMEM106B-geenimuutosten vaikutusmekanismeja. @UEFneuroscience @HiltunenLab @LabMalm uef.fi/fi/artikkeli/m…

@KuopioEpilepsy Workshop panel discussion on Biomarkers for Epilepsies and Neurodegenerative Diseases with Valtteri Julkunen (@FinnGen_FI), @rkalviainen, @HiltunenLab and Susanne Bäck (@CRiverLabs)

"Dementia is not one specific disease, instead it is an overarching term describing a group of diseases characterized by progressive cognitive decline, associated with degeneration of brain matter." Find out more by reading the post written by our PhD researcher Elena Ppali 🧠