Antonio Angelastro

Now online & open access: Article by @Isotope_Effect, @WillGoRow, @FlitschSabine & co-workers @UoMMIB Horner–Wadsworth–Emmons olefination of proteins and glycoproteins nature.com/articles/s4416…

Fully funded 2-year postdoc position (starting date: Jan/Feb 2024) on biocatalysis, enzyme engineering, and reaction cascades available in my group. Please share. kth.se/lediga-jobb/67…

It's very exciting to see the pre-print of Laura's paper (Selective N-terminal modification of peptides and proteins using acyl phosphates) out now on @ChemRxiv. She's done some awesome work and it's great to have been part of it. Check it out at: chemrxiv.org/engage/chemrxi…

Our Protein & Peptide Science Early Stage Researcher meeting will be held on 20th Oct 2023 at The Royal Society of Chemistry, Burlington House. More details are here: rsc.org/events/detail/…

@FlitschSabine discussing the power of biocatalysis in carbohydrate chemistry @EUROCARB21 . Superb masterclass!

Stop scrolling 👀… and register (for free) for the next @RSC_PPSG lunchtime seminars on protein and peptide science. This Friday 2nd June at 1 pm UK time, we have informal research talks from Guto Rhys (Cardiff) & @drandybrennan rsc.org/events/detail/…

@BiocatTUD Oh dear.

Things you never want to see

Great work from @Jacksangster6 @Turner_Biocat here in @J_A_C_S. Chemoenzymatic synthesis of chrial cyclic amines with amine oxidases and allylboronates. Well done becky and @juanmangas both involved too! pubs.acs.org/doi/10.1021/ja…

2 days left to apply for the PhD studentships in our group with @MosmedC @NCL_MedChem @EvaristeTechno1 @ChemistryNCL

@StephanHacker2 @ChemRxiv @FlitschSabine My wife, who is a traditional synthetic organic/medicinal chemist, is still recovering from the shock that you can indeed use HWE chemistry on an antibody.

Interesting @ChemRxiv preprint by the group of @FlitschSabine. They demonstrate the use of HWE olefinations for selective modification of aldehydes in (glyco)proteins. The resulting products can serve as electrophiles for further diversification. doi.org/10.26434/chemr…

Horner-Wadsworth-Emmons Olefination of Proteins and Glycoproteins | ChemRxiv doi.org/10.26434/chemr…

Our work with @the100footpole @YuanHeNWU on explaining the biphasic kinetics of OXA-48-like carbapenemases caused by chloride is out. "Discovery and molecular basis of chloride as an allosteric activator and catalytic inhibitor for Class-D lactamases" biorxiv.org/content/10.110…

@fryania @gbernardes_chem This is what I thought when I first read this outstanding work, and I am sure you people will win this next challenge in due time. Congrats!

@gbernardes_chem says "the enzymatic method will be useful for modifying insulin and similar peptides. But he adds that the method could be challenging to apply to larger proteins that have more lysine residues": agreed-we are excited about the challenge😅🧬#proteinengineering

Great to see our work highlighted @cenmag : Evolved enzymes help modify insulin cen.acs.org/biological-che… @beth_halford

After chairing the Biological Session III of @UoMChemistry postgraduate conference, I believe we shall have a bright future after all. @Baldwin_Chris_ @JessLlo32291290

Our review on chemoenzymatic cascades is under the "accepted articles" section at @EurJOC. Happy to be part of the #NextGenOrgChem special collection and congrats to Christian for his first contribution as the 1st author.@ARAID_ES @ISQCH_Divulga @AgEInves …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/ej…

Looking forward to #ChemBioIreland in August. Excellent speakers including: Nediljko Budisa, @Cochrane_lab, @FlitschSabine, @PhosphorusFive, @klanglab, Andreas Marx, @J_McGouran, Eddie Myers, @rtraines, Helma Wennemers & Valentin Wittmann. #ChemBio sites.google.com/view/chembioir…

Our work with the @FlitschSabine group on Thioester Mediated Biocatalytic Amide Bond Synthesis with In Situ Thiol Recycling is available as a preprint! Nice work by @Ch_Schnepel and Laura, with @YuqiYu7 @Isotope_Effect @RachelHeath82 @makslub and @AstraZeneca

A fully-funded international 3.5-yr PhD studentship available to join @JinGroupMIB at Uni of Manchester. Please spread the word! findaphd.com/phds/project/t…

📅 April 14, 🕒 3–4 pm CEST – Register for 🆓 and join the ONLINE #BeilsteinTalk “Cascading #Biocatalysis” with Sabine Flitsch, @FlitschSabine @OfficialUoM. 🔗 beilstein-institut.de/en/talks/bioca… #BeilsteinTalks #OrganicSynthesis #Enzymes #Biocatalysis

We are excited to share that our work on a multifunctional enzyme that catalyses conjugate reduction and reductive amination is out now in @nature! This was a collaboration with the Grogan group @YSBL, @Prozomix and @pfizer nature.com/articles/s4158…