Bini Ramachandran

As the critical analysis for whatever happened yesterday starts, the fundamental issue that many in America can't stand an assertive woman in a leading position will definitely be the point that won't get addressed..

Moving over to Bluesky. Please come and join us over there bsky.app/profile/lpdg.b… #teammassspec #proteomics

Hello @JProteomeRes, @J_ASMS, please come to the place where skies are blue.. #TeamMassSpec misses your updates..

A little spin-off from last week's @ELIXIREurope #BioHackathon: youtu.be/7l5gAFOm6VE

#teamMassSpec If you're in #proteomics or #mass spec and fancy starting or checking out the other place 🦋🟦 here is a good list to start you off, we're getting good representation there without the endless issues of this site. Starter pack available: go.bsky.app/HH7kqEh

Check out the 2024 Emerging Investigators Issue for @J_ASMS. The future of mass spectrometry is definitely in good hands!! pubs.acs.org/toc/jamsef/35/…

@UCDProteomics @J_my_sci @neely615 Thanks very much, Brett for sharing this.. It's too awesome..

@J_my_sci @neely615 Getting this on YouTube so you don't need to login to listen to it was way more complex than it needed to be, but I did it :) youtu.be/bgoRtiwgObY

This is mind boggling!! The analogies it is drawing to explain the basic concepts of proteomics are exemplary.. May be this is the solution to those communication challenges came up in latest episode of #TheProteomicsShow.. Generative AI is awesome..

We've joined Bluesky. bsky.app/profile/retrac…

@dschweppe1 Well.. As a habit (or by obsession), I try to ensure e10 BPC intensity for every whole cell lysate TMT-MS3 runs.. Just a way of making sure on-column load is good.. 7e9 is indeed a good response.. And I promise I am not this Reviewer 2..

Addressing reviewer concerns today as a means to stay calm in the face of world events may not have been the best idea… Got dinged by R2 as our basepeak intensity was “only” 7e9. So that I can educate myself, what average basepeak intensity means “high quality” data to you?

@neely615 @UCDProteomics @Wybenga_Groot Yayy.. Looking forward to #POTRH..

Spectra for 1536 single cells acquired over 40 SPD Slice-PASEF workflow.. ~40 days of acquisition! Btw Bruker provides a spectra library? 'Analyses were performed using a library-based approach (spectral library provided by BRUKER containing 67686 proteins and 13827 genes)' 🤔

@funtoshs @UCDProteomics @ProteomicsNews Sorry, don't have any information on this..

Is there any report in literature on passivating beads using a Lys/Arg-free protein for pull-down or IP-MS? #TeamMassSpec @ItsBiniR @UCDProteomics @ProteomicsNews

@the_ion_doctor Congratulations to the PIs.. Looking forward to seeing publications from the new project..

Super excited for this new research project to drop next month. Of course my co-PI has done most of the work so far, but I contribute as much as possible. Preprint below

2024 update from Human Plasma Proteome Project..#HPPP Always have a soft spot for HPPP updates as it was my PhD prelim writing assignment.. The first draft map was just published as a special issue in the journal Proteomics just in time to compile that assignment.. 🤓

This is great! @NIAIDNews have launched a collection of public domain illustrations (currently 550 individual icons) bioart.niaid.nih.gov

Apparently, a 1000 spectra per second de novo peptide sequencing tool, novor.cloud, enabled those diverse antibody sequence mapping generated from those plethora of protease digestions...

Hiring managers want applicants to show passion and dedication, but not overconfidence or exaggerations. A feature from @NatureCareers describes how to walk this line. go.nature.com/3YjMv1o

Degrader Tac-opedia 🔘PROTAC: E3 ligase-targeted proteolysis 🔘DUBTAC: Deubiquitinase stabilization 🔘LYTAC: Lysosome-targeted degradation 🔘Trivalent PROTAC: Multivalent E3 ligase 🔘AUTAC: Autophagy-targeted degradation 🔘RIBOTAC: RNA-targeted degradation 🔘RNA-PROTAC: RNA-binding E3 ligase 🔘BioPROTAC: Antibody/peptide proteolysis 🔘Aptamer-PROTAC: Aptamer proteolysis 🔘GlueTAC: Lysosomal traffic & degradation 🔘Peptide-PROTAC: Peptide-based E3 ligase 🔘NanoTAC: Nanobody-based E3 ligase H/T: Donggeon Kim on the HR app!