Formerly JNR

It’s been great interacting with our readers, reviewers, authors, editors, & others in 2024. As #JNR takes on new leadership, this page will transition to something else. Thanks, @SalahuddinMoh19! Here’s to an ultra productive 2025! 🥂🍾

Adolescent Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating illness with unknown origin, MRI studies reveal increased anterior hypothalamus connectivity, necessitating further investigation. Read: buff.ly/48Gsyqf #neuroscience #Medtwitter

Parvalbumin interneurons, linked to autism spectrum disorder, could be targeted for therapeutic interventions due to genetic and environmental factors, mutations, and oxidative stress. Read: buff.ly/3NKyBjK #neurosceince #medtwitter #neurotwitter

The study reveals gut vagal sensory neurons and the cNTSNA-to-vlBNST circuit modulate learned passive avoidance behavior in rats, suggesting a dynamic role in memory consolidation and extinction. Read: buff.ly/3Yeh1cY #neurosceince #Medtwitter #neurotwitter

NaV1.7–ChR2, NaV1.8–ChR2, and NaV1.9–ChR2 mice showed nocifensive behavior to blue light exposure, with paw withdrawal and shorter time spent in blue LED rooms compared to wild-type mice. Read: buff.ly/3BREAAV #neuroscience #Medtwitter #Neurotwitter

Treatment-resistant depression is linked to functional dysconnectivity of the thalamus, insula, superior temporal cortex, anterior paracingulate cortex, and cerebellum crus II. Read: buff.ly/4e15Mus #neuroscience #Medtwitter #Neurotwitter

Long-term finasteride treatment effectively alleviates depression and microglia complexity in Dgal-induced senescent male rats, reducing anxiety-like behaviors, metabolic disturbances, and brain inflammation. Read: buff.ly/4hdGg82 #neuroscience #Medtwitter

High motor impulsivity in rats is linked to low cortico-striatal function, but chemogenetic restoration can reduce motor impulsivity without affecting risky decision-making. Read: buff.ly/3Y1lzV8 #neuroscience #medtwitter #neurotwitter

PTZ-induced seizures resulted in short-term glial gene expression changes, with astroglial genes showing more significant alterations, affecting the neuroprotective profile of A2 cell activation. Read: buff.ly/3XSCGbO #neuroscience # Medtwitter #Neurotwitter

High nicotine dose in mice induces anxiety-like behavior, oxidative stress, proinflammatory cytokine secretion, and brain-derived neurotrophic factor reduction, while cannabidiol acts as anxiolytic, reducing cytokines and normalizing BDNF levels. Read: buff.ly/3MT0l5p

Recent discoveries reveal altered Stathmin-2 (Stmn2) function in humans with amyotrophic lateral sclerosis and in rodent models, leading to axon degeneration and motor impairment, crucial for neurodegeneration treatment. Read: buff.ly/4eq6WzY #neuroscience #medtwitter

Adverse social experiences in adulthood, like social defeat, promote vulnerability, while maternal separation and social defeat foster resilience, with activity-dependent plasticity crucial for overcoming adversity. Read: buff.ly/3Zm2Rsx #neuroscience #medtwitter

The study demonstrated significant changes in resting-state functional activity and connectivity in the left dorsolateral prefrontal cortex, confirming its effects in both proximal and distant cortical areas. Read: buff.ly/3z8Kwo6 #neuroscience #medtwitter #Neurotwitter

IL-4, derived from immune cells, stimulates Ly6C+ macrophages to express BDNF, leading to a significant decrease in BDNF, IL-4 protein lev, and BDNF+/Ly6C+ cell quantity. Read: buff.ly/47g5Q7N #neuroscience #Medtwitter #Neurotwitter

Resistance exercise training has neuroprotective, antioxidant, & anti-inflammatory properties, preventing inflammatory diseases like memory loss and lipid peroxidation in Wistar rats, thereby increasing protein density. Read: buff.ly/3T07m80 #neuroscience #medtwitter

Study highlights schizophrenia's disrupted connectivity between the amygdala and DMDN, emphasizing resting-state functional connectivity in understanding treatment efficacy & symptom improvement. Read: buff.ly/4709vGw #neuroscience #medtwitter #neurotwitter

A study on rat ages revealed that chloride reversal potential (ECl) varies with age and SCN region, with ventral SCN experiencing more hyperpolarization and negative at night. Read: buff.ly/3SJiS7I #neuroscience #medtwitter #neurotwitter

The study investigates the age dynamics of SMI-32-immunopositive neurons in cats' dorsal lateral geniculate nucleus and primary visual cortex, using antibodies to track neuronal maturation and motion processing. Read: buff.ly/3AeHn6q #neuroscience #medtwitter#neurotwitter

The study found (+)-catechin can alleviate neuropathic pain in male rats undergoing CCI surgery by triggering the Nrf2-induced antioxidant system, inhibiting TLR4/NF-κB, and producing ROS. buff.ly/4ftyOVm #neuroscience #medtwitter