
Johnson Thomas, MD, FACE
4.9K posts

Johnson Thomas, MD, FACE
@JohnsonThomasMD
Endocrinologist. Passionate about thyroid nodules, cancer & AI. Creator of Endo Tools iphone app,TUMScore, AIBx. Tweets ≠ medical advice. Retweets ≠ endorsement








Today, we are emerging from stealth and launching PrismML, an AI lab with Caltech origins that is centered on building the most concentrated form of intelligence. At PrismML, we believe that the next major leaps in AI will be driven by order-of-magnitude improvements in intelligence density, not just sheer parameter count. Our first proof point is the 1-bit Bonsai 8B, a 1-bit weight model that fits into 1.15 GBs of memory and delivers over 10x the intelligence density of its full-precision counterparts. It is 14x smaller, 8x faster, and 5x more energy efficient on edge hardware while remaining competitive with other models in its parameter-class. We are open-sourcing the model under Apache 2.0 license, along with Bonsai 4B and 1.7B models. When advanced models become small, fast, and efficient enough to run locally, the design space for AI changes immediately. We believe in a future of on-device agents, real-time robotics, offline intelligence and entirely new products that were previously impossible. We are excited to share our vision with you and keep working in the future to push the frontier of intelligence to the edge.






What if a single H&E slide could reveal 21 protein markers without ever touching an antibody? Built a 3D interactive viewer around Microsoft's GigaTIME model — upload an H&E tile, run inference, and explore DAPI, CD3, CD8, PD-L1, Ki67 and 16 more channels as a rotatable point cloud The tumor microenvironment, decoded from routine staining 🧬 #DigitalPathology #AI #Oncology


Everybody wants AI to help cure cancer. Why isn't every AI company obsessively focused on that?



You can now enable Claude to use your computer to complete tasks. It opens your apps, navigates your browser, fills in spreadsheets—anything you'd do sitting at your desk. Research preview in Claude Cowork and Claude Code, macOS only.






