Chinese Journal of Natural Medicines

Complement C3 drives kidney inflammation and fibrosis. This CJNM study demonstrates that SPX-derived peptide AAQFFNR inhibits complement C3 activation, protects renal function, and attenuates fibrosis in nephropathy models. Peptidomics + molecular docking + in vivo validation highlight insect-derived peptides as a promising therapeutic avenue. 📖Mechanistic insight for natural reno-protective therapy 🔗 Read on ScienceDirect：sciencedirect.com/science/articl… #Nephropathy #MantidisOotheca #BioactivePeptides #ComplementC3 #CJNM

Can herbal combinations repair the gut barrier in ulcerative colitis? The AR–AM pair (e.g., Astragalus and Atractylodes) may: • Activate Epac1/Rap1 & inhibit PI3K/AKT 🧬 • Restore tight junctions & MUC2 expression • Improve goblet cell density & reduce inflammation • Lower disease activity in UC models A multi-target approach to restoring intestinal integrity. Could this strategy translate into new UC therapies? #UlcerativeColitis #TCM #GutBarrier #PI3KAKT #Inflammation #CJNM

Can a green tea compound fight Hepatitis B?🍵 EGCG may suppress HBV by: • Activating AMPK/TFEB → boosting autophagy 🧬 • Reducing viral load & HBV proteins • Enhancing lysosomal function & energy metabolism Blocking autophagy reverses its effect—highlighting a key mechanism. Could EGCG inspire safer antiviral strategies? #HepatitisB #EGCG #Autophagy #AntiviralResearch

Read on：doi.org/10.1016/S1875-…

Could coltsfoot hold new anti-diabetic compounds? Four new sesquiterpenoids, including a novel 2,3-seco oplopane skeleton, were discovered in Tussilago farfara. They improve glucose uptake in muscle cells and reduce inflammatory signals in macrophages. ✨ Highlights: • Enhances glucose metabolism • Reduces inflammatory signaling • Fully characterized structures via quantum chemical calculations #NaturalProducts #TussilagoFarfara #AntiDiabetic #DrugDiscovery #Pharmacology

🔗 Read the full study 👇 🔗 ScienceDirect: sciencedirect.com/science/articl…

❤️ Could ancient TCM formulas help your heart at the cellular level? Mitochondria = your heart’s “energy factories” 🧬 TCM decoctions like Shenfu and Buyang Huanwu: • Restore mitochondrial function • Reduce oxidative stress & calcium overload • Improve heart pumping & exercise tolerance 💪 • Lower risk of major cardiovascular events ⚡ Multi-target, holistic strategies make TCM a unique ally for chronic heart failure. #HeartHealth #TCM #MitochondrialMedicine #Cardiology #CJNM

Click to read: sciencedirect.com/science/articl…

🌳 Can a plant-derived compound enhance brain acetylcholine? 🧠 Huperzia serratum (HupA) rapidly penetrates the brain, reversibly inhibits AChE, and elevates acetylcholine in key regions—even in stroke-model rats (MCAO). ✨ Highlights: • Blood PK predicts brain ACh dynamics via mPBPK-PD modeling • Optimized dosing can maximize cognitive benefit • Potential application in memory decline and post-stroke cognitive dysfunction #Neuroscience #MemoryEnhancement #StrokeRecovery #CognitiveHealth #BrainResearch

🧠 Linking blood PK to brain acetylcholine: Huperzine A mPBPK-PD modeling A recent study reveals Huperzia serratum (HupA) reversibly inhibits AChE and increases cerebral ACh in multiple brain regions in rats, including ischemic models (MCAO). Using a minimal physiologically based PK-PD (mPBPK-PD) model, researchers accurately predicted brain ACh dynamics from systemic HupA pharmacokinetics. ✨Key insights: • Rapid brain penetration & enhanced exposure with multiple dosing • Modulates acetylcholine & monoamine neurotransmitters • Supports individualized dosing optimization for cognitive disorders #HuperzineA #Acetylcholine #Neuroprotection #PKPDModeling #CognitiveScience

Click to read: sciencedirect.com/science/articl…

🧪 Can a plant extract “boost” brain acetylcholine? Huperzia serratum (HupA) penetrates the brain rapidly, reversibly blocks AChE, and raises acetylcholine levels in key brain regions—even in stroke-model rats (MCAO). ✨ Highlights: • Blood PK predicts brain ACh dynamics via mPBPK-PD modeling • Optimized dosing can maximize cognitive benefit • Potential for treating memory decline & post-stroke cognitive deficits #BrainBoost #Acetylcholine #Memory #Neuroprotection #StrokeResearch

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🧪 How can a traditional herb make cancer cells “self-destruct”? Researchers found Dendrobium officinale triggers ferroptosis, an iron-dependent cell death, in colorectal cancer cells. ✨ Highlights: • Disrupts cancer cells’ lipid defense → cells die • Spares healthy cells • Shrinks tumors in mouse models #CancerBreakthrough #ChineseMedicine #Ferroptosis #ColorectalCancer #DendrobiumOfficinale

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❤️ Can a classical Chinese formula actually slow down atherosclerosis? Taohong Siwu Decoction (THSWD) tackles multiple AS drivers: • Reduces inflammation & cytokines 🌿 • Protects endothelial cells • Modulates key pathways: NF-κB, PI3K/AKT, MAPK 🧬 ⚠️Multi-target, TCM-based strategies may offer safer, holistic cardiovascular protection. #HeartHealth #TCM #CardioResearch #NaturalCompounds #CJNM

👉 Read the full study 👇 🔗 Science Direct : sciencedirect.com/science/articl…

Can natural compounds make stem cell therapies actually work? MSCs promise tissue repair & immune modulation—but clinical results are often inconsistent. ✨ Natural products can: • Boost MSC survival & homing • Promote tissue-specific differentiation • Enhance immune regulation 🧬 ⚠️ Safer, multi-target strategies may finally unlock MSCs’ full therapeutic potential. #StemCells #NaturalProducts #RegenerativeMedicine #TCM #CJNM

read more: 🔗 DOI: doi.org/10.1016/S1875-…

🌿 Could a turmeric-derived compound become a multi-disease therapy? Curdione shows: • anticancer • anti-inflammatory • antiviral • multi-organ protection But here’s the catch: ⚠️ poor solubility & potential toxicity limit its clinical use This review connects chemistry → metabolism → mechanism, offering clues for turning a promising natural product into a real drug. #DrugDiscovery #CancerResearch #NaturalCompounds #TCM #CJNM

🔗 Full study: sciencedirect.com/science/articl…

🧠 Can a traditional herb protect your nerves during chemotherapy? • Schefflera kwangsiensis extract eases oxaliplatin-induced neuropathic pain 🌿 • Activates SERCA2b, restores DRG neuron function, and reduces pain-causing inflammation • Helps normalize neuron excitability, combat oxidative stress, and prevent cell death ⚡ • Natural, science-backed approach to chemotherapy nerve protection #ChemotherapySupport #NeuropathicPain #SERCA2b #ScheffleraKwangsiensis #TCM #Neuroprotection