Jungmann Lab

We hope G5M helps push quantitative molecular mapping forward, and we’re excited to see the discoveries it enables. Thanks to @rafalkowalew, @SusanneReinhar3, @IBaudrexel, Shuhan Xu, @l_masu, for developing G5M and the rest of the @JungmannLab for testing and improving it. 7/7

G5M is implemented in Picasso since version 0.9.5: github.com/jungmannlab/pi…, although we always recommend using the most recent version! A short documentation: #g5m" target="_blank" rel="nofollow noopener">picassosr.readthedocs.io/en/latest/rend…. We advise reading the whole paper for best results! 6/7

In DNA-PAINT, nearby proteins create overlapping localizations. You may see two by eye, but analysis often misses them, wasting precious precision. G5M solves this. Now in @NatureComms: doi.org/10.1038/s41467… 1/7

Big congrats to @CSteinek, @IBaudrexel, and Sebastian Strauss who led the project as well as other co-authors that contributed to this work!! 6/6

Importantly, this workflow is broadly applicable and compatible with virtually any high off-rate binder. Many “bad” binders currently sitting in lab freezers may now become powerful imaging tools. 5/6

Up to 15-fold improvement in protein labeling for DNA-PAINT 🧬🔬. We are excited to present our latest work published in @angew_chem! onlinelibrary.wiley.com/doi/10.1002/an…

How do you scale super-resolution microscopy to dozens of proteins without linearly scaling imaging time? We introduce Combi-PAINT: a combinatorial DNA-PAINT strategy that breaks the 1-target-per-round bottleneck of Exchange-PAINT: biorxiv.org/content/10.648… 1/5

#pictureofthemonth: The pic shows 30 different protein types with spatial resolution in a neuronal "atlas“ created with the imaging method SUM-PAINT. Find out more: biochem.mpg.de/jungmann November – institute calendar of @MPI_Biochem and @MPIforBI Image by Eduard Unterauer

Now online: October 2025 Issue. - Focus Issue on #biosensing - DNA moiré superlattices - Sugars at Ångström-resolution - Solid-state #nanopores - Non-aqueous Li #batteries - Neuromorphic vision - Peptide #hydrogels - Deep learning for #LNPs & more. nature.com/nnano/volumes/…

Our article "Ångström-resolution imaging of cell-surface glycans" on the cover of Nature Nanotechnology! 🤩 @NatureNano nature.com/nnano/volumes/…

Thrilled to announce some big news! I’ve been awarded a Wellcome Trust Early Career Award to establish my research as a Group Leader in the Glycosciences Program at the Institute of Biology and Experimental Medicine (IBYME) in Buenos Aires, Argentina, starting early 2026.

Huge thanks to all authors and collaborators whose effort made this possible. @EduardUnterauer @EvaSchentarra @IBaudrexel @taisha_tashrin Jisoo Kwon Sebastian Strauss @jekriste @rafalkowalew @FelipeOpaz_o @euforna @l_masu (6/6)

Within this neuronal atlas we can reveal the three synapse classes, excitatory, inhibitory and the recently discovered mixed synapse. Organelle imaging of Peroxisomes (Pmp70) and the Golgi Apparatus (Golga5) reveals rare contact sides and even fused particles. (5/6)

Highly efficient 12-color multiplexing with speed-optimized DNA-PAINT. We are excited to share our latest publication in @NatureComms, using left-handed DNA to extend speed-optimized DNA-PAINT to 12 targets in a simple and straightforward way! 🧬👈🚀nature.com/articles/s4146…