Keisuke Motone / 元根 啓佑

金銭的な理由で研究を続けるのが困難だという方がおられましたら、私の研究グループ（阪大・工・生物工学）をご検討下さい。博士研究員さんであれば学振PD以上、学生さんであれば学振DC相当額で3年間は雇用できます。こちらの論文に興味がマッチするようでしたらご連絡下さい。nature.com/articles/s4158…

Zero-Dalton Resolution in Nanopore Peptide Recognition | Analytical Chemistry pubs.acs.org/doi/full/10.10…

Single-Feature Identification of α2–8 Linked Sialoglycans Using Engineered Aerolysin Nanopores: A Paradigm for Glycan Linkage Analysis | Journal of the American Chemical Society pubs.acs.org/doi/full/10.10…

β-barrel nanopores designed for insertion into thick block copolymer membranes biorxiv.org/content/10.648…

Single-molecule peptide sequencing through reverse translation of peptides into DNA go.nature.com/4sRPr2K

Wang et al., Nanopore-based massively parallel sensing for peptide profiling and protein identification | Nature Communications nature.com/articles/s4146…

The Next Generation of Protein Sequencing and Analysis Methods - go.shr.lc/4rEUUd1

Terminal Conjugation Enables Nanopore Sequencing of Peptides | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

2027年4月採用の学振DC•PDの募集が始まったので宣伝します！僕のグループで一緒に研究してくれる方を探しています。学振申請書の作成は全力サポートしますので、「タンパク質デザイン」「タンパク質編集」に興味のある方はぜひ連絡ください。 #u20230706114917" target="_blank" rel="nofollow noopener">jsps.go.jp/j-pd/pd_sin.ht…

プレプリントを公開しました。タンパク質のアミノ酸配列を”編集”する方法についての研究です。 “Programmable protein editing by split intein-mediated recombination” biorxiv.org/content/10.648…

New Huang Lab publication! We functionalized nanopores with a metal ion to achieve identification of biogenic amines in spoiled food, showcased with a spoiled shrimp. Thisoffers a reliable way to assess food freshness and food safety. pubs.acs.org/doi/10.1021/ac…

🧬New paper in Analytical Chemistry! We developed a background-free nanopore decoding strategy for microRNA identification using circular diagnostic DNA on a MinION device. doi.org/10.1021/acs.an…

New paper in Analytical Chemistry! We reconstructed smooth-type lipopolysaccharide (LPS) outer membranes with O-antigen using a microdevice-based droplet contact method. 🔗 doi.org/10.1021/acs.an…

Single-molecule identification of full-length proteins with single-amino-acid resolution using nanopores biorxiv.org/content/10.648…

Huang lab new publication! 🧪🔬 Simplified nanopore design: IDA-modified (weaker coordination, single-ligand mode) for simultaneous detection of 10+ common divalent metal ions (Fe, Ni, Cu, Pb, Cr, etc.), no complex setup! nature.com/articles/s4422…

萩原ラボのスタッフ(助教or准教授or特任助教)公募が出ましたので、興味のある方は是非コンタクトして下さい！RT and/or spread the wordもよろしくお願いします〜。 jrecin.jst.go.jp/seek/SeekJorDe…

Huang lab new publication! 🍠🥔 Budget-friendly💰💰💰 science at its finest: we turned potatoes/sweet potatoes into breakthroughs: starch+nanopore= monosaccharide-resolution maltodextrin discrimination + distinct amylose/amylopectin signals! pubs.acs.org/doi/full/10.10…

New Huang Lab publication. Assembling Lego within a nanopore cavity: Nanopore saccharide profiling and sequencing by fragmentation. science.org/doi/10.1126/sc…

Design Strategies toward Precise Protein Sequencing with Biological Nanopores | Analytical Chemistry pubs.acs.org/doi/full/10.10…

New paper in NAR to close out 2025! Structure-informed models that predict nanopore ionic current levels for expanded DNA alphabets (XNAs). We show how chemical structure + sequence context can help scale basecalling to new chemistries. Check it out: academic.oup.com/nar/article/53…

Protein editing is an exciting frontier. Imagine being able to edit proteins like we edit DNA with CRISPR.