Kyle Cottrell

I am absolutely thrilled to announce that I will be starting my own lab @PurdueBiochem @PUCancerCenter @Purdue in January 2023. The Cottrell Lab will study RNA editing and post-transcriptional regulation in cancer and normal physiology. 1/5

PACT suppresses PKR activation, thus preventing activation of the integrated stress response, NF-κB, and cell death. Dimerization and double-stranded #RNA binding by PACT is required for this function. bit.ly/4oC3Vm7 @KyleCottrell @PurdueBiochem @PUCancerInst

This is my first research article as sole corresponding author and the first from the Cottrell lab. I'm very happy that it ended up at RNA. This is my first time publishing in RNA and this was by far my best review experience to date. Huge thanks to editor and reviewers!

This manuscript was accepted @RNAJournal and is online ahead of publication now! Congratulations to first author Addison Young and all the co-authors (for several this is their first publication). @PurdueBiochem @PUCancerInst. rnajournal.cshlp.org/content/early/…

This evening, the newest Cottrell Lab graduate student, Cassandra Smoak, will be presenting poster 402. Over the last few months she has been evaluating a recently published ADAR1 inhibitor - ZYS-1. I'll let her tell you if it is a good inhibitor or not... #RNA25

@AdelitaMendoza7 Thanks Adelita!

@KyleCottrell Way to go Kyle!!

Just in time for #RNA25, the Cottrell Lab has posted our first independent preprint to bioRxiv. This is the first first-author publication from graduate student Addison Young and the first publication for the four undergraduate co-authors. biorxiv.org/content/10.110… 1/2

@RemiBuisson Thanks!

@KyleCottrell Great paper!!

Thanks to @PurdueBiochem @PUCancerInst and @NIMHD for support. Head over to Bluesky for a thread describing the work bsky.app/profile/kyleco…. 2/2

@PurdueBiochem @PUCancerInst at #RNA25

I'm thinking of shifting careers. I figure a job as a truck lift-kit salesperson would be more in line with the interests of our society, or maybe a job in the iron lung industry. There's gonna be a lot of demand there soon.

The things we are teaching them in class didn't materialize out of thin air. They were discovered thanks to the hard work of scientists, and that work in almost all cases was enabled by federal research funding. Especially funding for basic science. 5/n

that arouse from studying bacterial immune systems - CRISPR-Cas9. All of this to make the point that funding basic science is essential to advancing human health and our society. After the election, it's a good idea for us to remind our students of the importance of research. 4/n

Yesterday, during my lecture on Roundup and Roundup resistance, I spent a few minutes talking about restriction enzymes. I described how the study of bacterial resistance to phage infection led to one of the most consequential molecular biology discoveries ever. 1/n

@mike_feigin I'm from Missouri. We have been doing this for decades. This initiative and all the other more liberal initiatives that passed today while the nation elected a facist really highlight how the presidential election is not at all about policy for most people.

We are about to get a lot of analysis and punditry to explain the election results. Let me simplify it for everyone - it's sexism.

Nerd thought, I think we are at the 'Great Filter'. I'm not sure we are going to make it past it at the rate we are going.

How am I going to break this to my daughter? How do I explain that this despicable person is going to be president again? That a lot of people, especially men, could put aside his racism, misogyny, and fascism, and vote for him. Or did they vote for him because of those things?

WTF is wrong with men in this country?

@PatrickKerstein I did. Well, it was on a timer.

Somehow, I've managed to teach today and run a PCR (gel and all). Is my phone nearly dead already? Yes. Have I done anything else productive? No