Bokai Zhu lab

It is a great pleasure to share our most recent work on ‘rejuvenating’ nuclear speckles to ameliorate proteinopaties such as Tauopathy and retinitis pigmentosa. It is my first publication that is not related to biological rhythms and I am very excited to nature.com/articles/s4146…

and how their dysfunction contributes to ALS/FTD and tauopathies

and proteostasis, and how their dysfunction contributes to ALS/FTD and tauopathies. Great collaboration with Xu Chen, and thanks to editor Moran Furman for his guidance. authors.elsevier.com/a/1mjZRbotqBbS7 #Neurodegeneration #RNAbiology #BiomolecularCondensates #Proteostasis #ALS #Tauopathy

What if a tiny nuclear structure helps determine whether neurons survive or degenerate? Our new Trends in Neurosciences review explores how nuclear speckles—dynamic nuclear condensates once thought to be passive splicing hubs—coordinate RNA metabolism, stress responses,

This is consistent with our own work on the importance of 12h ultradian rhythms in liver function.

Hepatic metabolic functions follow a 12-hour cycle rather than a 24-hour cycle, significantly contributing to the liver’s ability to meet nutrient demands throughout the day! link.springer.com/article/10.100…

I am so sad to hear the passing of Dr. Bert O’Malley today. He has been a great mentor for me and has always been my inspiration for pursuing science. The world has lost a great scientist and mentor today.

Sadden to hear the passing of Dr. Bert O’Malley, the father of molecular endocrinology, a long-time mentor, and friend.

Pyrvinium as a nuclear speckle rejuvenator independently validated in a new study. SWING domains prime chromatin for nuclear body–mediated gene regulation biorxiv.org/content/10.110…

Glad to see this paper finally out. It was a fascinating story when it first came out as a preprint a few years back.

Collective homeostasis of condensation-prone proteins via their mRNAs: nature.com/articles/s4158…

#Postdoc opportunity at Columbia U. in New York! We are interested in candidates from biochemistry backgr. & excited about fractionation, purification and reconstitution to study autonomous clocks in the cell cycle, in colab. w/ @Aydinlab at NYU! hhmi.wd1.myworkdayjobs.com/External/job/C…

GraphVelo allows for accurate inference of multimodal velocities and molecular mechanisms for single cells | Nature Communications nature.com/articles/s4146…

LYVAC/PDZD8 is a lysosomal vacuolator | Science science.org/doi/10.1126/sc…

Perhaps our boldest hypothesis… we propose a model for RNA Structural Memory propagation @NatureCellBio, where RNA conformation is reshaped by stress, locked by RBPs, copied prion-like in condensates & passed across generations—all without altering DNA.🧵 rdcu.be/eBwPJ

I completely agree.

A multichaperone condensate enhances protein folding in the endoplasmic reticulum: nature.com/articles/s4155…

Antiparasitic Drug Shows Power Against Alzheimer’s and Dementia today.ucsd.edu/story/antipara…

Excited to see the work by @Yale_INP students Suzhou Yang @Denethi_W w/ collabs @YaleNeuro iPSC core @jdpereira @ArabTanina and @MayoClinicNeuro @gendron_tania @NeuroUdit on #C9orf72 #ALS & #FTD finally out in @NatureNeuro! @WuTsaiYale @KavliAtYale nature.com/articles/s4159…

Nuclear speckle rejuvenation “next frontier” for treating neurodegeneration, via @EurekAlert! eurekalert.org/news-releases/…

A news article on our work. Nuclear Speckle Rejuvenation “Next Frontier” for Treating Neurodegeneration - UPMC & Pitt Health Sciences News Blog inside.upmc.com/nuclear-speckl…