Ewa Langner

It's #fluorescencefriday and we've got a wonderful image for you. The inside front cover of the #cilia and #flagella #special issue. Enjoy! onlinelibrary.wiley.com/toc/19493592/2… @LangnerEP

It's #microscopymonday!🔬 Super happy that special issue on @CytoskelJournal is out now with the beautiful cover🤩🥳@MahjoubLab

For #FluorescenceFriday we have another wonderful #picture of the month in #CYTOSKELETON @CytoskelJournal Enjoy! @LangnerEP @MahjoubLab #microscopy #kidney

Happy to share one of the pictures of the month @CytoskelJournal😍🔬🩵 Happy #FluorescentFriday to y'all!

@MahjoubLab @UTSWNephrology Thanks Moe! My microscopy adventure started in your lab 🔬🩵

Happy #FluorescenceFriday all! 🔬🌈 And big congrats to my former postdoc @LangnerEP (now @UTSWNephrology) for having her beautiful image of an embryonic #kidney selected as an "Image of Distinction" in the 50th anniversary #NikonSmallWorld competition!

Check out these amazing winning images of Nikon 2024 Photomicrography Competition! #NikonSmallWorld Congratulations to all the winners of this year's edition!👏👏🔬nikonsmallworld.com/galleries/2024…

Extremely excited about the future at @UTSWNephrology and Suleiman Lab @hansul.

My 5-year long, amazing adventure at WashU @MahjoubLab come to an end. Extremely grateful for how much I have learned. The biggest thank you to my great mentor, Dr Moe Mahjoub, but also to all faculty of @WUNephrology and Cilia and Centrosome Group at WashU.

Congratulations to the @MahjoubLab for their recent publications detailing the critical role of #centrosomes in #kidney development and function, one landing cover of @JCI_insight! Great work by first-authors @ChengTao_PKD, @LangnerEP and all co-authors. nephrology.wustl.edu/mahjoub-lab-ce…

Perfect day #FluorescenceFriday to celebrate my image of🐭kidney getting onto the cover @JCI_insight🫣😍💜🙌 Plus, additional opportunity to one more time celebrate great paper from the lab @MahjoubLab @ChengTao_PKD 👏🍾

#Cover: Inhibiting centrosome clustering reduces cystogenesis & improves #kidney function in autosomal dominant polycystic kidney disease: buff.ly/42LHtN1 Image: immunofluorescence staining of developing embryonic mouse kidney; credit: Ewa Langner. @MahjoubLab @WUSTLmed

Our latest study is now published @JCI_insight and OMG WE GOT THE COVER! 😱😱😱 Congrats to my amazing postdoc @ChengTao_PKD for this herculean effort (~5 yrs), and to @LangnerEP for the beautiful image that made the cover 😍 Lemme tell you about our study real quick👇

Hey #nephrology aficionados: Are you interested in achieving nanoscale (<50nm) level resolution of organelles, cytoskeletal components, and other subcellular structures? Would you like to avoid doing electron microscopy? Then let me tell you how 👇 biorxiv.org/content/10.110…

Happy #FluorescenceFriday & #GroundhogDay!

Women are 4-times more likely to have autoimmune diseases than men. Why is this? From Dou et al. in Cell, today In females, the second X chromosome is silenced by a long non-coding RNA, called Xist (pronounced 'exist') - males don't express Xist Xist, together with almost 100 unique proteins, wraps itself around the second X chromosome, silencing it. It's thought that Xist-protein complexes are highly immunogenic, and may represent targets for autoantibodies Dou et al. devised a system to induce expression of Xist in male mice. They found that Xist expression led to the production of autoantibodies, similar to levels found in female mice (RIBO P0/P2 are lupus autoantibodies, CENPA/B are scleroderma autoantibodies): In a mouse model, these autoantibodies in Xist-expressing males were sufficient to cause significant lupus pathology (including in the kidney and the lung): In humans, autoantibodies against the Xist ribonucleoprotein complex were enriched in female patients with lupus, scleroderma, and dermatomyositis Therefore, Xist may solve the puzzle of female-biased autoimmunity cell.com/action/showPdf…

Cep120 is essential for kidney stromal progenitor cell growth and differentiation. -> embopress.org/doi/full/10.10…

Live views of @ChengTao_PKD and Ewa Langner celebrating their third manuscript acceptance in a month 🍾 Happy long weekend, all!

Protein #CEP120, essential for #centrosome function, underlies normal #kidney function & injury repair. Image & research by Ewa Langner et al @MahjoubLab @WUNephrology @WUSTLmed in @emboreports. On bpod.org.uk/archive/2024/1… where you'll find the article links & 4000+ BPoD archive