Lyn Jones

@GMBurslem Well done George!

Thank you to all the friends, collaborators, lab members and mentors who made this happen!

A week late, but I was able to complete my Jimmy Fund Walk today - thank you to everyone who supported me! #JimmyFundWalk

I’m taking steps to defy cancer at the Jimmy Fund Walk. Every donation to my walk will make an impact on the lives of patients and families at Dana-Farber. #JimmyFundWalk danafarber.jimmyfund.org/site/TR?fr_id=…

Chemistry rewires biology: subtle changes to glutarimide analogs reshape degron selectivity, reprogramming CRBN toward new ZF targets.

Want to be at the forefront of next-generation covalent chemical biology? Open postdoctoral fellow positions in my lab: careers.dana-farber.org/job/11941/post… careers.dana-farber.org/job/11940/post…

Advances are being made to rationally design and develop cereblon-based molecular glue degraders - here's a perspective on their property-based optimization pubs.acs.org/doi/full/10.10…

🎉 2025 DFCI TPD event registration is open! 📆 Sep 11, 11:30 AM–8 PM ET, Boston 🔑 Keynote: Nathanael Gray 📝 Registration link: forms.gle/NLUSa51Btrtf6F… #TPD #ProteinDegradation #DrugDiscovery #Boston #DFCI

We are delighted to announce that our 2024 Emerging Investigators collection is now online👀 This themed collection aims to highlight the achievements of some early career researchers in the medicinal chemistry community. Access it here👉 pubs.rsc.org/en/journals/ar…

📢We are delighted to announce that @MichaelBollong (@scrippsresearch) has been awarded the 2025 RSC Medicinal Chemistry Emerging Investigator Lectureship🎉 Join us in congratulating Michael and read our blog to find out more about him and his work: blogs.rsc.org/md/2025/01/30/…

'Linkerless' PROTACs? Structure-guided design of a truncated heterobivalent chemical probe degrader of IRE1α - now published in @rsc_medchem pubs.rsc.org/en/content/art… #PROTAC #TPD

🔓Take a look at recent #OpenAccess research by Xiaoyu Zhang (@xzhang85) and colleagues on exploiting the DCAF16–SPIN4 interaction to identify DCAF16 ligands for PROTAC development🔥 pubs.rsc.org/en/content/art… 📍@NorthwesternU

Also in this month's issue is an update on Target 2035 from @CherylArrowsmi1, Stefan Knapp and colleagues covering the efforts of the EUbOPEN project which is contributing to the goals of #Target2035💡 Read the #OpenAccess article here⬇ pubs.rsc.org/en/content/art…

Curious about #RSCPoster? Our latest video explains everything you need to know about this exciting competition! Discover how you can showcase your research, gain recognition, & connect with fellow scientists. Watch the video and get inspired - Register rsc.li/3BtGKH7

Exploration of degrons and their ability to mediate targeted protein degradation - now published in RSC Medicinal Chemistry pubs.rsc.org/en/content/art…

@DanNomura @ETH_en A great honor Dan - congrats!

We’re excited to share the story of the discovery and early clinical development of JNT-517, our oral small molecule drug candidate being evaluated in PKU, in the peer-reviewed journal @JCI_insight. Access it here: bit.ly/4g5Qpm7

Great event - registration open now!

As a heads up I'm being impersonated on X - please ignore any posts and direct messages from them.

Characterization of a Novel Macrocyclic Molecular Glue That ... : Journal of the American Society of Nephrology journals.lww.com/jasn/abstract/…

We're excited to share our most recent publication in the journal ACS Chemical Biology on a novel corrector for variants of SLC6A8 as a potential treatment approach for creatine transporter deficiency (#CTD). bit.ly/3YXaPrv @ACSPublications #raredisease #genetics