Manoj Doss not exist

Now that it has been out for a week, I thought I’d address a few strange takes regarding our recent mega-analysis on the effects of psychedelics on brain function (specifically, resting-state functional connectivity). 1/15 nature.com/articles/s4159…

@winstonian3 It's still not really interpretable what any of those changes mean in (let me check my notes) 7 people...

@ManojDoss siegel study compared to methylphenidate and saw same kind of differences. ppl def weren’t asleep on that

Now that it has been out for a week, I thought I’d address a few strange takes regarding our recent mega-analysis on the effects of psychedelics on brain function (specifically, resting-state functional connectivity). 1/15 nature.com/articles/s4159…

We have enough resting-state data & they'll eventually be shared so I'm advocating for theory-driven task-based studies where we constrain the inference space, see how the brain solves problems differently on psychedelics, & find real cognitive enhancements on psychedelics. 15/15

Bc of this nebulous comparison that doesn't tether brain activity to mental states, there have unfortunately been a lot of bizarre reverse inferences (inferring mental activity from the brain despite brain activity from fMRI being able to show up under several conditions). 14/15

I'll be giving a talk on psychedelics & memory via Zoom tomorrow. You can register for it here: open-foundation.org/events/online/…

@RCarhartHarris Except the Bayesian analysis found fairly inconclusive evidence for changes in within-network FC including in the DMN...

A very familiar profile of effects seen when pooling across teams and studies...

Mega analysis of psychedelic fMRI studies: nationalgeographic.com/health/article… via @NatGeo @MGirnNeuro

This paper has been a long time coming. Instead of reanalyzing the same old resting-state fMRI datasets, we combined nearly all datasets around the world. Note that we didn't exactly find indisputable evidence for "default mode network disintegration." nature.com/articles/s4159…

Just reviewed my first paper written by AI! Shame on not only the first author but the relatively long list of authors who didn't realize this🤦🏾