MetaStem

Follow MetaStem, The Centre of Excellence in Stem Cell Metabolism on Bluesky 🦋 Seuraa meitä Blueskyssa bsky.app/profile/metast…

News from our CoE by Henna Tyynismaa and Ruben Torregrosa Munumer labs. Mitochondrial ATP synthase deficiency results in Metabolic trade-offs and vulnerabilities in stem cell derived motor neurons nature.com/articles/s4200…

Welcome to the PhD defense of @_HienBui Age-selective segregation of organelles in asymmetric stem cell division, on Fri 7 Nov at 1 pm, Biocenter 2, 2041. Opponent Prof Carien Niessen, University of Cologne @helsinkiuni @HiLIFE_helsinki @MIBS_Helsinki #publicdefense #phddefense

Next MetaStem PhD defense in two days 👏 go Hien! 🎩

Still time today to sign up and submit an abstract for this excellent symposium

Next MetaStem PhD defense coming up on Tuesday. Go Simon 👏

Welcome to the Stem Cell Seminar this Friday bsky.app/profile/metast… @HiLIFE_helsinki @STEMMProgram @MIBS_Helsinki

Check out our website for more info and updates helsinki.fi/en/researchgro…

Excited to announce our Stem Cell Metabolism Symposium organized Nov 12th in Helsinki. Fantastic invited speakers Marcia Haigis, Lydia Finley, Matthias Hebrok, Tom MacVicar. Sign up by Oct 22nd, free of charge, welcome! @HiLIFE_helsinki @helsinkiuni @STEMMProgram @MIBS_Helsinki

Welcome to the Metabolism seminar tomorrow Sept 9th 9-11 in Viikki bsky.app/profile/metast… @HiLIFE_helsinki @MIBS_Helsinki @BIOTECH_UH @STEMMProgram

News from our CoE by @KatajistoLab Andersson et al found that intestinal stem cells with old mitochondria make Paneth cells faster due to higher aKG levels and aKG improves regeneration in old animals by Paneth cell renewal nature.com/articles/s4225… @SuomenAkatemia @helsinkiuni

News from our CoE by @OtonkoskiL @EliisaVhk et al show that upon engraftment into mice stem cell derived pancreatic islets become insensitive to pyruvate, correlating with down regulation of pyruvate/lactate transporter MCT1 link.springer.com/article/10.100… @SuomenAkatemia @helsinkiuni

Proudly presenting Simon’s paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism @NatMetabolism nature.com/articles/s4225… @helsinkiuni @HiLIFE_helsinki @SuomenAkatemia @MetaStem_Center

News from our CoE by @HTyynismaa group characterize the role of mitochondrial intermembrane space protein CHCHD10 in metabolism and spinal muscular atrophy Jokela type (SMAJ) actaneurocomms.biomedcentral.com/articles/10.11… Congratulations Sandra Harjuhaahto! @SuomenAkatemia @helsinkiuni @STEMMProgram

New from our CoE by @KatajistoLab show how tissue stem cells can metabolically regulate tissue renewal and differentiation by providing daughter cells with peroxisomes of different age and metabolic properties nature.com/articles/s4146… @SuomenAkatemia @helsinkiuni @HiLIFE_helsinki

A new study from our CoE finds that stem cells can control whether they self-renew or differentiate by localizing certain metabolic reactions differently helsinki.fi/en/faculty-bio… @SuomenAkatemia @helsinkiuni @KatajistoLab @BIOTECH_UH @MIBS_Helsinki @_HienBui @PekkaKatajisto

Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells nature.com/articles/s4146… @MetaStem_Center @helsinkiuni @karolinskainst @BIOTECH_UH @MIBS_Helsinki @SuomenAkatemia out now in @NatureComms Congrats @_HienBui et al!

Next Stem Cell Seminar April 23rd, welcome! bsky.app/profile/metast… @HelsinkiUniMed @HiLIFE_helsinki @STEMMProgram @BIOTECH_UH @FIMM_UH

The @KatajistoLab modeled #epithelial regeneration using small intestinal scaffolds and identified #asporin is a mediator of fetal-like reprogramming. Read the @CellStemCell article: bit.ly/41LJbhn Listen to the conversation: bit.ly/3FBkNHR

Welcome to the next Metabolism seminar, March 18th at 9-11 am in Meilahti. Excellent speaker lineup with and @DrPietilainen and Robin Cristofari groups presenting about #obesity #adiposetissue #diet #aging in humans and penguins @STEMMProgram @BIOTECH_UH @HelsinkiUniMed