PacBio

A bright new day is here! 🦋 Follow us on Bluesky (bsky.app/profile/pacbio…) and stay connected for updates, innovations, and everything genomics. #PacBio

Think you know long-read sequencing? Put your knowledge to the test. Assumptions in cancer genomics change fast. At #PacBio, we are debunking the biggest myths about cost, FFPE samples, and throughput with the latest HiFi data. Get the facts: bit.ly/4bks8ZB

#PacBio is proud to partner with Basecamp Research to generate high-fidelity metagenomic data for the Trillion Gene Atlas, a landmark initiative to model biological data at the trillion-gene scale and accelerate AI-designed therapeutics. Learn more: bit.ly/479RQh3

HiFi = accuracy. But how? HiFi reads are generated by combining multiple passes around a single DNA molecule. By merging repeated observations, the system produces long reads with greater than 99.9% accuracy. Watch the full video to see under the hood: bit.ly/3YSPBdo

Rare ataxias and population genetics are the two areas of human genomics that fascinate Dr. Birgitt Scheule of Stanford University. Watch the full episode of BEYOND THE BENCH to learn about her work: bit.ly/4pl2YPa Which area of human genetics fascinates YOU most?

To fully understand cancer, researchers must see the genome and its epigenetic state at once. Learn how the upcoming SPRQ-Nx chemistry and software release expands #PacBio HiFi sequencing to 5mC, 6mA, and 5hmC with new economics to help you scale. Blog: bit.ly/3NlDnba

Last call! Join our webinar this week to see how #PacBio HiFi sequencing and spatial transcriptomics reveal deeper insights into cancer than short reads. Learn about isoform heterogeneity and immune profiling at near-single-cell resolution. Register: bit.ly/3OQE1Od

Cancer is complex. Your sequencing shouldn’t be. Discover how #PacBio HiFi sequencing reveals the full spectrum of cancer variation, from structural variants and methylation to RNA isoforms and fusions, in a single technology. Check out the brochure: bit.ly/4sCizuO

How can HiFi sequencing unlock deeper insights into cancer biology than short reads for gene fusions and isoforms? Our new series shows how researchers use #PacBio to drive discoveries in methylation and structural variation. Watch now: bit.ly/3P78pnA #CancerResearch

At #ACMGMtg26? Our workshop starts in one hour! ⏰ Join Nina Gonzaludo (PacBio) and Lucy Kaplun (Variantyx) in Exhibit Theater 2 to hear how #PacBio HiFi sequencing is streamlining diagnostics research and advancing clinical whole genome testing. See you there soon!

1 month to go until #PacBioPRISM 2026 in Barcelona! Registration is now open, we’re excited to bring the #Genomics community together for learning, conversation & connection. <10% of spots left. Register: bit.ly/412nkSE #HiFiSequencing

Step inside the research shaping the future of cancer genomics. See how #PacBio HiFi reveals hundreds of structural variants, novel isoforms predicting survival, and fusions with treatment implications all in a single technology. Explore the guide: bit.ly/4b83Z8E

Watch Deborah Moine at #ACMGMtg26 explain her poster on optimized DNA extraction from low-mass samples for #PacBio HiFi long-read sequencing. Visit booth #2321 to meet our experts and learn how HiFi sequencing delivers a complete view of variation in a single assay.

New preprint: Hunting for MSI in long-read data with Owl🦉 Owl is an MSI caller for PacBio HiFi, integrated into our somatic analysis workflow. Data: • Low baseline (~1–5%) • 15–18% MSI-H instability • Links GGAA repeats to EWS::FLI1 fusion Details: bit.ly/4beWECU

Happening today at 12:15 PM! Join Matt Holt at #ACMGMtg26 for his talk on how #PacBio HiFi sequencing enables the discovery of pharmacogenomic haplotypes. 📍 Platform C ⏰ 12:15 PM Not attending? Learn more about StarPhase for HiFi PGx: bit.ly/4b4ACUA

A new paper in Cell Genomics validates how #PacBio HiFi sequencing unlocks ASD research. By replacing multiple assays with one workflow, researchers saw a 33% increase in SV detection and a 38% increase in tandem repeat detection. Read the study.👇 bit.ly/4sAnkFd

Repeat expansions cause 50+ neurological disorders but are difficult to measure. Dr. Schüle from Stanford University uses HiFi sequencing to directly profile complex repeats and advance research in Parkinson’s disease and SCA10. Read about her work.👇 bit.ly/4bz4Y1z

11,674 steps toward hope. Sean Baumstark, founder of De:terminence, Inc., is climbing the world’s longest stairway this July. Living with Friedreich’s ataxia, his journey reminds us why the work in our labs matters. Join us at #PacBioPRISM: bit.ly/4b0Mt4F #PacBio

Join us at #ACMGMtg26 to see how HiFi sequencing is redefining genetic testing. We are featuring two posters: • P165: CFTR profiling using PureTarget panels (Billy Rowell) • P636: DNA extraction from low-mass samples (Deborah Moine) Details: bit.ly/3OBZmee

How does HiFi capture epigenetics in one run? When a base is modified, its incorporation rate shifts. HiFi measures these kinetic signatures to detect 5mC and 6mA automatically with no extra library prep. Watch our newest explainer video to see how: bit.ly/3YSPBdo

Decoding cancer requires resolving transcript diversity within intact tissue. Join our webinar to see how long-read sequencing and near-single-cell spatial transcriptomics reveal isoform diversity and map immune receptor clonotypes in tumors. Register: bit.ly/3OQE1Od